Used to detect hg 2+ Aggregation-induced luminescent fluorescent sensor and its preparation method and application

Abstract

The invention discloses an Hg2+ detecting aggregation-induced emission type fluorescent sensor and a production method and application thereof. The structural formula of the fluorescent sensor is as shown in specification. The fluorescent sensor is of aggregation-induced emission property and is nonluminous in solution, and its fluorescent light is enhanced in an aggregation state, accordingly, the fluorescent sensor can be applied to recognition of highly specific selectivity and anti-interference performance of Hg2+. Besides, the fluorescent sensor has high biocompatibility and cellular permeability, can target mitochondria in cells and light the Hg2+ in mitochondria by fluorescent light, and accordingly can realize detection of Hg2+ in the mitochondria.

Description

technical field

[0001] The invention belongs to the technical field of environmental detection and biological detection, and in particular relates to a 2+ Detected aggregation-induced luminescence type fluorescence sensor and preparation method and application thereof. Background technique

[0002] Hg 2+ It is notorious for its great pollution and very serious harm to the human body. Hg 2+ After entering the human body, it will cause damage to the human central nervous system, brain, endocrine system, kidneys, liver, heart and other organs. The chemical properties of mercury in nature depend entirely on its chemical state in nature, inorganic Hg 2+ After entering the water body, it is converted to methylmercury in various ways. Methylmercury has a strong affinity with sulfhydryl groups in proteins and is deposited in organisms, and its concentration increases with the circulation of the food chain. Pregnant women who eat mercury-contaminated marine organisms for a long...

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