The present invention relates to heterogeneous copper-supported manganese-oxygen octahedral molecular sieves (CuO x / OMS-2) The synthetic method of catalyzing 4,5-dicyanoimidazole derivatives, the method is in organic solvent, with a kind of diaminomaleonitrile derivative as substrate, in CuO x The reaction occurs under the catalytic condition of / OMS-2 to obtain a 4,5-dicyanoimidazole derivative. In the new synthesis method, the raw materials and catalysts are simple and easy to obtain, the atomic economic benefit is high, the yield of heterocycles is high, and the operation is simple. The structure of the 4,5-dicyanoimidazole derivatives involved in the present invention is shown in structural formula I. Wherein R is benzene ring, thiophene, pyrrole, naphthalene, tetraphenylene, triphenylamine, by alkyl, OMe, CF 3 , OH, X (halogen) benzene ring substituted by any one or more substituents.