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A kind of synthetic method of tetraphenylene compound

A synthesis method and compound technology are applied in the synthesis field of tetraphenylene compounds, which can solve the problems of many reaction steps and low production efficiency, and achieve the effects of short reaction steps, simple operation and mild reaction conditions.

Active Publication Date: 2020-04-28
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the reaction step of above-mentioned synthetic method is relatively many, and production efficiency is relatively low

Method used

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  • A kind of synthetic method of tetraphenylene compound
  • A kind of synthetic method of tetraphenylene compound
  • A kind of synthetic method of tetraphenylene compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～16

[0033] Add 2-iodobiphenyl, palladium catalyst palladium acetate, silver salt, and trifluoroacetic acid into the reaction tube, and stir at 100°C; after a period of reaction, cool the reactant to room temperature, add ethyl acetate to it for extraction, and extract The organics gathered together were filtered with diatomaceous earth; saturated sodium bicarbonate solution was added to the filtrate to wash until the pH of the aqueous phase was neutral; the collected organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure at 40°C. After separation by column chromatography (petroleum ether, elution), the obtained white solid is tetraphenylene (1a):

[0034]

[0035] 1 H NMR (400MHz, CDCl 3 ):δ7.29(m,8H),7.18(m,8H);

[0036] 13 C NMR (100MHz, CDCl 3 ): δ141.51, 129.00, 127.21;

[0037] HRMS(ESI-TOF)m / z:calcd for C 24 h 16 Na + :327.1144(M+Na) + ,found: 327.1142..

[0038] Note: the palladium acetate used in the above examples was pu...

Embodiment 7

[0043] For Example 6 and Example 7, Ag 2 CO 3 and Ag 2 The amount of O is 0.3mmol, which is equivalent to 0.6mmol of Ag, which shows that the addition of too much Ag will inhibit the oxidative addition of palladium to the carbon-iodine bond of the substrate, resulting in the inability of the reaction to proceed downward. For Example 14, the reaction cannot proceed without adding catalyst palladium, indicating that palladium is necessary.

Embodiment 17～21

[0045] Replace the reaction substrate with 2-iodobiphenyl compounds with substituents, palladium acetate, silver carbonate, trifluoroacetic acid, and stir at 100°C; after a period of reaction, cool the reactant to room temperature, and add acetic acid to it Ethyl extraction, the organic matter gathered together after extraction and filtered with diatomaceous earth; Add saturated sodium bicarbonate solution to the filtrate and wash until the pH of the aqueous phase is neutral; After the collected organic phase is dried with anhydrous sodium sulfate, the Concentrate under reduced pressure at 40°C, and separate by column chromatography (petroleum ether, elution), and the obtained white solid is tetraphenylene compound (2a, 4a, 5a, 6a). Investigate the impact of different 2-iodobiphenyl compounds on the synthetic method of the present invention, its concrete reaction formula can be expressed as:

[0046]

[0047] Wherein, R is fluorine, chlorine, methyl or phenyl.

[0048] The...

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Abstract

The invention relates to a synthesis method of a tetraphenylene compound. The structure of the tetraphenylene compound is as shown in the description. The synthesis method comprises the following steps of adding a 2-iodobiphenyl compound, a palladium catalyst and silver salt into an organic solvent, carrying out a heating reaction, separating a product, and then drying, so that a target product is obtained. The 2-iodobiphenyl compound is a mixture of a compound A and a compound B; the structural formulas of the compound A and the compound B are as shown in the description respectively, wherein R1, R2, R3 and R4 are all one of hydrogen, alkyl, halogen or aryl. Compared with the prior art, the synthesis method has advantages that the reaction step is short, the time is short, the efficiency is high, the yield is high, the reaction condition is mild, the operation is simple and convenient, and the like.

Description

technical field [0001] The present invention relates to a synthetic method of a compound, in particular to a synthetic method of a tetraphenylene compound. Background technique [0002] Tetraphenylene is composed of an eight-membered ring formed by ortho-condensation of four benzene rings. It has a non-planar saddle structure with two pairs of opposite benzene rings pointing up and down on the molecular mean plane, respectively. Tetraphenylene and its derivatives are of great research interest due to their unique geometric shapes. In addition, it has potential applications in various fields such as materials science, supramolecular chemistry, asymmetric catalysis, etc. [0003] At present, the conventional methods for synthesizing tetraphenylene compounds are as follows. The first method utilizes 2,2'-dibromobiphenyl or 2,2'-diiodobiphenyl through lithiation, and then self-coupling by transition metal to obtain tetraphenylene, such as literature (Rajca, A.; Wang , H.; Bo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C13/62C07C1/26C07C43/21C07C41/30C07C25/22C07C17/269
CPCC07C1/26C07C17/269C07C41/30C07C2531/04C07C13/62C07C43/21C07C25/22
Inventor 张扬会江航
Owner TONGJI UNIV
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