The invention belongs to the technical field of pesticides, and particularly relates to an indole spiropyridino coumarin compound as well as a preparation method and application thereof. According to the present invention, the isatin derivative, the 1, 3-dicarbonyl compound and the 4-aminocoumarin are adopted as the raw materials, the indole spiropyridino coumarin compound is synthesized through the one-pot method, and the indole spiropyridino coumarin compound has characteristics of unique chemical structure, higher research value and higher application potential. The preparation method provided by the invention has the advantages of cheap raw materials, simple process and strong universality, and is suitable for industrial production. Particularly, the method for preparing the indole spiropyridino coumarin compound by taking water as a solvent has the characteristics of being green, safe, efficient and environment-friendly. The indole spiropyridino coumarin compound provided by the invention has good bacteriostatic activity, has inhibitory activity on common plant pathogenic bacteria such as peanut brown spots, apple ring spots, wheat sheath blight, watermelon anthracnose and rice seedling, and has a potential application value.