Reinforced degradable intravascular stent material and preparation method thereof

Abstract

The invention discloses a reinforced degradable intravascular stent material and a preparation method thereof. The reinforced degradable intravascular stent material comprises the following components: L-polylactide, polyglycolic acid, chitosan oligosaccharide, glycidyl methacrylate, aliskiren hemifumarate, nizofenone fumarate, D-threitol, erythritol, glycodeoxycholic acid sodium, silk fibroin, L-eucine ethyl ester hydrochloride, sodium acryloyldimethyl taurate, disodium beta-glycerophosphate, itaconyl chitosan, nano zirconium dioxide, acetic acid, dichloromethane and hexafluoroisopropanol. The stent material provided by the invention reaches degradation time of 65 to 79 days, has a hemolytic rate of lower than 3.5%, is excellent in blood compatibility, and can reduce adverse effects which cause thrombus; moreover, a stent made of the reinforced degradable intravascular stent material is high in supporting force and strong in anti-fracture strain capacity, a thickness of the stent can be further reduced, and the reinforced degradable intravascular stent material is beneficial to blood circulation and application of small molecule vessels. The stent material provided by the invention is safer, more reliable and more effective to use and has an excellent application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a reinforced degradable vascular stent material and a preparation method thereof. Background technique [0002] Tissue engineering refers to the technology of using biologically active substances to rebuild or repair organs and tissues through in vitro culture or construction. In the process of culturing cells, it is necessary to use a degradable scaffold material, so that the scaffold material implanted in the lesion will gradually degrade as the cells continue to grow, and after new tissue is formed, the scaffold Material degrades completely. Therefore, in the field of tissue engineering, the degradability and biocompatibility of scaffold materials are of great significance. [0003] The technology of interventional treatment of diseases has been developed to the stage of degradable stents. Compared with non-degradable stent materials, degradable ste...

AI Technical Summary

Problems solved by technology

However, the degradable stent materials in the prior art also have the following disadvantages: the mechanical properties are insufficient, and the stent support force of the traditional metal stent cannot be achieved, resulting in the thicker thickness of the existing degradable stent, and the material fracture strain is easy to occur; in addition, The degradation rate of degradable stents also needs to be further improved