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Preparation method of polyelectrolyte drug-loaded particles

A technology of polyelectrolyte and drug-carrying particles, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., to achieve high drug loading and encapsulation efficiency, stable performance and smooth surface. Effect

Inactive Publication Date: 2016-12-14
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are few reports about PEC microparticle carriers

Method used

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  • Preparation method of polyelectrolyte drug-loaded particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] In this example, polyelectrolyte drug-loaded particles were prepared according to the following steps:

[0034] (1) Preparation of dispersed phase

[0035] Dissolve sodium alginate in distilled water, stir evenly and remove air bubbles to obtain 10 mL of sodium alginate (NaAlg) solution with a concentration of 0.02 g / mL as the dispersed phase;

[0036] (2) Preparation of continuous phase

[0037] Mix Span 85 and Tween 85 at a volume ratio of 7:3, take 3 mL and add it to 100 mL of liquid paraffin, stir evenly, and use it as the continuous phase;

[0038] (3) homogeneous emulsification

[0039] Pour the dispersed phase prepared in step (1) into the continuous phase prepared in step (2), and homogeneously emulsify for 5 minutes at a stirring rate of 3000 rpm to obtain a homogeneous emulsion;

[0040] (4) Cross-linking curing

[0041] Add 20mL 0.06g / mL CaCl to the homogeneous emulsion 2 With a mixed solution of 0.025g / mL NaCl, solidify and react at a stirring rate of 3...

Embodiment 2

[0053] In this example, polyelectrolyte drug-loaded particles were prepared according to the following steps:

[0054] (1) Preparation of dispersed phase

[0055] Dissolve sodium alginate in distilled water, stir evenly and remove air bubbles to obtain 10 mL of sodium alginate (NaAlg) solution with a concentration of 0.02 g / mL as the dispersed phase;

[0056] (2) Preparation of continuous phase

[0057]Mix Span 85 and Tween 85 at a volume ratio of 5:5, take 3 mL and add it to 100 mL of liquid paraffin, stir evenly, and use it as the continuous phase;

[0058] (3) homogeneous emulsification

[0059] Pour the dispersed phase prepared in step (1) into the continuous phase prepared in step (2), and homogeneously emulsify at a stirring rate of 3000 rpm for 10 minutes to obtain a homogeneous emulsion;

[0060] (4) Cross-linking curing

[0061] Add 20mL 0.06g / mL CaCl to the homogeneous emulsion 2 With a mixed solution of 0.025g / mL NaCl, solidify and react at a stirring rate of 3...

Embodiment 3

[0073] In this example, polyelectrolyte drug-loaded particles were prepared according to the following steps:

[0074] (1) Preparation of dispersed phase

[0075] Dissolve sodium alginate in distilled water, stir well and remove air bubbles to obtain 10 mL of sodium alginate (NaAlg) solution with a concentration of 0.03 g / mL as the dispersed phase;

[0076] (2) Preparation of continuous phase

[0077] Mix Span 85 and Tween 85 at a volume ratio of 1:3, take 4 mL and add it to 100 mL of liquid paraffin, stir evenly, and use it as the continuous phase;

[0078] (3) homogeneous emulsification

[0079] Pour the dispersed phase prepared in step (1) into the continuous phase prepared in step (2), and homogeneously emulsify at a stirring rate of 3000 rpm for 15 minutes to obtain a homogeneous emulsion;

[0080] (4) Cross-linking curing

[0081] Add 20mL 0.06g / mL CaCl to the homogeneous emulsion 2 With a mixed solution of 0.025g / mL NaCl, solidify and react at a stirring rate of 30...

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Abstract

The invention discloses a preparation method of polyelectrolyte drug-loaded particles. The method is characterized by comprising the following steps: by using a sodium alginate solution as a disperse phase, Span 85 and Tween 85 as mixed emulsifiers and liquid paraffin as a continuous phase, carrying out homogenizing emulsifying, crosslinking curing, drug loading and electrostatic coating to obtain the polyelectrolyte drug-loaded particles. The preparation method has the advantages of simple preparation technique, low cost and low facility requests, and is suitable for mass preparation. The drug-loaded particles have the advantages of uniform size, smooth surface, high drug loading amount, high coating rate and stable performance, and are suitable for drying and vacuum packaging preservation.

Description

technical field [0001] The invention relates to a preparation method of polyelectrolyte drug-loaded microparticles, belonging to the technical field of carrier preparation. Background technique [0002] Drug Delivery Systems (DDS), also known as drug delivery system, is a hot field of modern pharmacy research. The research and development of DDS comprehensively utilizes the theories and technologies of multiple disciplines such as physics, chemistry, biology, biomedicine, polymer science, and material science. Carrier preparation technology and material development and utilization are the research core of DDS. Drug carriers prepared by traditional technologies such as prodrug technology, matrix technology, coating technology, and capsule technology are in urgent need of innovation due to problems such as burst release, solvent residue, and drug leakage. With the rapid development of modern pharmacy, physical, chemical, and engineering techniques are used to construct carri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/513A61K47/36A61K47/26A23L33/125A23P20/17
CPCA61K9/5036A23V2002/00A61K31/513A61K47/26A61K47/36A23V2200/30A23V2250/51A23V2250/511
Inventor 吴庆喜王丹丹乔艳华董雪纯陈彦
Owner ANHUI UNIVERSITY
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