Novel high-strength high-hydrophilia oxidized graphene-P34HB nanofiber scaffold and preparing method and application thereof

Abstract

The invention relates to a novel high-strength high-hydrophilia oxidized graphene-P34HB nanofiber scaffold and a preparing method and application thereof. The method includes the steps that (1) P34HB is modified with oxidized graphene, and an oxidized graphene-P34HB modification electrospinning solution is obtained; (2) the oxidized graphene-P34HB modification electrospinning solution is subjected to electrostatic spinning with the electrospinning technology, and the modified nanofiber membrane scaffold is obtained. According to the novel high-strength high-hydrophilia oxidized graphene-P34HB nanofiber scaffold and the preparing method and application, the P34HB is modified with the oxidized graphene for the first time, the modified biological scaffold is prepared with the electrospinning technology, the mechanical performance of the scaffold is greatly improved, and meanwhile the hydrophilia of the scaffold is improved; fibers of the scaffold are continuous, collapse and adhesion are avoided, and the porosity up to 91.4%, the high specific surface area and excellent hole communication performance are achieved; the scaffold has better biosecurity, and meanwhile has certain osteogenic induction capacity.

Description

technical field [0001] The invention relates to the technical field of preparation of biopolymer material tissue engineering scaffolds, in particular to a novel high-strength and highly hydrophilic graphene oxide-P34HB nanofiber scaffold and its preparation method and application. Background technique [0002] Clinically, due to various reasons (trauma, infection, cyst and tumor, surgical debridement of osteomyelitis, congenital diseases, etc.), the structural integrity of the bone is destroyed, which is called bone defect; clinically, there are various repair methods for bone defect; Allogeneic bone transplantation has the disadvantages of opening a second operation area, complicated operation, large trauma, and immune rejection; artificial bone transplantation has shortcomings such as insufficient osteogenesis and insufficient strength of the material; and distraction osteogenesis takes a long time. It is expensive and has strict indications. Bone tissue engineering techn...

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Problems solved by technology

[0005] In recent years, the application potential of P34HB in the biomedical field has attracted attention. However, the shortcomings of the P34HB polymer itself, such as hydrophobicity and low strength, greatly limit its application in the biomedical field. Therefore, it is of great significance to modify its weaknesses.

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