Novel high-strength high-hydrophilia oxidized graphene-P34HB nanofiber scaffold and preparing method and application thereof

A-P34HB, nanofiber technology, applied in fiber processing, fiber chemical characteristics, rayon manufacturing, etc., can solve problems such as limitation and low strength, and achieve the effect of enhancing mechanical strength, improving mechanical properties, and improving mechanical properties

Active Publication Date: 2017-02-01
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In recent years, the application potential of P34HB in the biomedical field has attracted attention. However, the shortcomings of the P34HB polymer itself

Method used

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  • Novel high-strength high-hydrophilia oxidized graphene-P34HB nanofiber scaffold and preparing method and application thereof
  • Novel high-strength high-hydrophilia oxidized graphene-P34HB nanofiber scaffold and preparing method and application thereof
  • Novel high-strength high-hydrophilia oxidized graphene-P34HB nanofiber scaffold and preparing method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0047] A method for preparing a novel high-strength and highly hydrophilic graphene oxide-P34HB nanofiber scaffold, comprising:

[0048] (1) Graphene oxide is added in chloroform, ultrasonically dispersed at 30000Hz for 4 hours to obtain a graphene oxide-chloroform mixed solution; get P34HB, add the graphene oxide-chloroform mixed solution obtained in step (1), and magnetically stir for 1 -3 hours, obtain the graphene oxide-P34HB modified electrospinning solution; wherein, the P34HB concentration is 0.17g / ml, the graphene oxide concentration is 2mg / ml, and the mass ratio of P34HB and graphene oxide is 85:1;

[0049] (2) Transfer the above-mentioned graphene oxide-P34HB modified electrospinning solution to 10ml, 21G (that is, the inner diameter is 0.5mm) metal needle syringe, connect the metal clip of the machine as the positive electrode of electrospinning, and use the metal cylinder covered with tin foil as the electrospinning positive electrode. Negative pole, set the receiv...

Embodiment 2

[0052] A method for preparing a novel high-strength and highly hydrophilic graphene oxide-P34HB nanofiber scaffold, comprising:

[0053] (1) Graphene oxide is added in chloroform, ultrasonically dispersed at 40000Hz for 3 hours to obtain a graphene oxide-chloroform mixed solution; get P34HB, add in the graphene oxide-chloroform mixed solution obtained in step (1), and magnetically stir for 1 -3 hours, obtain graphene oxide-P34HB modified electrospinning solution; wherein, the concentration of P34HB is 0.15g / ml, the concentration of graphene oxide is 0.5mg / ml, and the mass ratio of P34HB and graphene oxide is 300:1.

[0054] (2) Transfer the above-mentioned graphene oxide-P34HB modified electrospinning solution to 10ml, 21G (that is, the inner diameter is 0.5mm) metal needle syringe, connect the metal clip of the machine as the positive electrode of electrospinning, and use the metal cylinder covered with tin foil as the electrospinning positive electrode. Negative pole, set th...

Embodiment 3

[0057] A method for preparing a novel high-strength and highly hydrophilic graphene oxide-P34HB nanofiber scaffold, comprising:

[0058] (1) Graphene oxide is added in chloroform, ultrasonically dispersed at 40000Hz for 3 hours to obtain a graphene oxide-chloroform mixed solution; get P34HB, add in the graphene oxide-chloroform mixed solution obtained in step (1), and magnetically stir for 1 -3 hours to obtain graphene oxide-P34HB modified electrospinning solution; wherein, the concentration of P34HB is 0.15g / ml, the concentration of graphene oxide is 1mg / ml, and the mass ratio of P34HB to graphene oxide is 150:1.

[0059] (2) Transfer the above-mentioned graphene oxide-P34HB modified electrospinning solution to 10ml, 21G (that is, the inner diameter is 0.5mm) metal needle syringe, connect the metal clip of the machine as the positive electrode of electrospinning, and use the metal cylinder covered with tin foil as the electrospinning positive electrode. Negative electrode, se...

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Abstract

The invention relates to a novel high-strength high-hydrophilia oxidized graphene-P34HB nanofiber scaffold and a preparing method and application thereof. The method includes the steps that (1) P34HB is modified with oxidized graphene, and an oxidized graphene-P34HB modification electrospinning solution is obtained; (2) the oxidized graphene-P34HB modification electrospinning solution is subjected to electrostatic spinning with the electrospinning technology, and the modified nanofiber membrane scaffold is obtained. According to the novel high-strength high-hydrophilia oxidized graphene-P34HB nanofiber scaffold and the preparing method and application, the P34HB is modified with the oxidized graphene for the first time, the modified biological scaffold is prepared with the electrospinning technology, the mechanical performance of the scaffold is greatly improved, and meanwhile the hydrophilia of the scaffold is improved; fibers of the scaffold are continuous, collapse and adhesion are avoided, and the porosity up to 91.4%, the high specific surface area and excellent hole communication performance are achieved; the scaffold has better biosecurity, and meanwhile has certain osteogenic induction capacity.

Description

technical field [0001] The invention relates to the technical field of preparation of biopolymer material tissue engineering scaffolds, in particular to a novel high-strength and highly hydrophilic graphene oxide-P34HB nanofiber scaffold and its preparation method and application. Background technique [0002] Clinically, due to various reasons (trauma, infection, cyst and tumor, surgical debridement of osteomyelitis, congenital diseases, etc.), the structural integrity of the bone is destroyed, which is called bone defect; clinically, there are various repair methods for bone defect; Allogeneic bone transplantation has the disadvantages of opening a second operation area, complicated operation, large trauma, and immune rejection; artificial bone transplantation has shortcomings such as insufficient osteogenesis and insufficient strength of the material; and distraction osteogenesis takes a long time. It is expensive and has strict indications. Bone tissue engineering techn...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/08A61L27/50A61L27/56D04H1/728D01D5/00D01F6/92D01F1/10
CPCA61L27/08A61L27/18A61L27/50A61L27/56A61L2430/02D01D5/0015D01F1/10D01F6/92D04H1/728C08L67/04
Inventor 林云锋周腾飞李果蔡潇潇林世宇刘瑶田陶然
Owner SICHUAN UNIV
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