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Polyglycollide material applicable to medical catheter and preparation method of polyglycollide material

A polyglycolide, medical catheter technology, applied in the direction of catheter and other directions, to achieve the effect of good application prospect, high biological safety and simple process

Inactive Publication Date: 2017-02-01
胡何辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of this material on medical catheters has yet to be developed, and its stability and biological safety need to be further enhanced. Therefore, it is particularly important to develop a polyglycolide material that can be used in medical catheters.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Weigh 20 parts of polyglycolide, 10 parts of polyethylene glycol, 4 parts of citric acid ester, 2 parts of acetic acid, 5 parts of chitosan, and 3 parts of 2-ethyl-4-methylimidazole according to parts by weight , 5 parts of toluene diisocyanate, 2 parts of phosphatidylcholine, 4 parts of phenylenedioctyl phosphite, 7 parts of pentaerythritol oleate, 2 parts of sodium naphthalene acetate, 4 parts of diaminodiphenyl sulfone, phosphite-benzene 3 parts of diisooctyl ester, 1 part of dibutyltin dilaurate;

[0023] (2) Add polyglycolide, polyethylene glycol, citric acid ester, acetic acid, and chitosan into the reaction kettle, pressurize, react at high temperature, the pressure is 2MPa, the reaction temperature is 260°C, the reaction time is 50 minutes, and then Cool down to 240°C, add 2-ethyl-4-methylimidazole, phenylenedioctyl phosphite, stir evenly and keep warm for 10 minutes to obtain a high-temperature reactant;

[0024] (3) Add toluene diisocyanate, phosphatidylc...

Embodiment 2

[0031] (1) Weigh 25 parts of polyglycolide, 12 parts of polyethylene glycol, 5 parts of citric acid ester, 3 parts of acetic acid, 7 parts of chitosan, and 4 parts of 2-ethyl-4-methylimidazole according to parts by weight , 6 parts of toluene diisocyanate, 3 parts of phosphatidylcholine, 5 parts of phenylenedioctyl phosphite, 8 parts of pentaerythritol oleate, 3 parts of sodium naphthalene acetate, 5 parts of diethylenetriamine, 4 parts of epoxy soybean oil part, 2 parts of stannous octoate;

[0032] (2) Add polyglycolide, polyethylene glycol, citric acid ester, acetic acid, and chitosan into the reaction kettle, pressurize, and react at high temperature. The pressure is 2.4MPa, the reaction temperature is 280°C, and the reaction time is 50 minutes. Then lower the temperature to 240°C, add 2-ethyl-4-methylimidazole and epoxidized soybean oil, stir evenly and keep warm for 13 minutes to obtain a high-temperature reactant;

[0033] (3) Add toluene diisocyanate, phosphatidylchol...

Embodiment 3

[0040] (1) Weigh 35 parts of polyglycolide, 14 parts of polyethylene glycol, 7 parts of citric acid ester, 3 parts of acetic acid, 9 parts of chitosan, and 6 parts of 2-ethyl-4-methylimidazole according to parts by weight , 8 parts of toluene diisocyanate, 4 parts of phosphatidylcholine, 6 parts of phenylenedioctyl phosphite, 9 parts of pentaerythritol oleate, 4 parts of sodium naphthalene acetate, 6 parts of 2-methylimidazole, aluminum stearate 7 parts, 2 parts of acetyl tributyl citrate;

[0041] (2) Add polyglycolide, polyethylene glycol, citric acid ester, acetic acid, and chitosan into the reaction kettle, pressurize, and react at high temperature. The pressure is 2.8MPa, the reaction temperature is 320°C, and the reaction time is 50 minutes. Then lower the temperature to 240°C, add 2-ethyl-4-methylimidazole and aluminum stearate, stir evenly and keep warm for 18 minutes to obtain a high-temperature reactant;

[0042](3) Add toluene diisocyanate, phosphatidylcholine, phe...

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Abstract

The invention discloses a polyglycollide material applicable to a medical catheter. The polyglycollide material is prepared from the following raw materials in parts by weight: 20-45 parts of polyglycollide, 10-15 parts of polyethylene glycol, 4-8 parts of citrate, 2-4 parts of acetic acid, 5-10 parts of chitosan, 3-7 parts of 2-ethyl-4-methylimidazole, 5-9 parts of toluene diisocynate, 2-5 parts of phosphatidylcholine, 4-7 parts of diisooctyl phenyl phosphite, 7-10 parts of pentaerythritol oleate, 2-5 parts of naphthalene sodium acetate, 4-7 parts of a curing agent, 3-8 parts of a stabilizer and 1-3 parts of a catalyst. The prepared polyglycollide material applicable to the medical catheter is stable in properties and relatively high in biological safety, and the polyglycollide material can achieve self-degradation in vivo. Meanwhile, the invention also discloses a preparation method of the polyglycollide material applicable to the medical catheter.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a polyglycolide material that can be used for medical catheters and a preparation method thereof. Background technique [0002] Polyglycolide, also known as polyglycolic acid or polyglycolic acid, is the simplest linear polyester among polyhydroxyalkanoates. The raw material of polyglycolide is glycolic acid, which widely exists in nature, especially in sugarcane, sugar beet and immature grape juice, and is currently obtained industrially through organic synthesis. Polyglycolide is a thermoplastic linear polyester with certain processability, and can be extruded, injected, spun, blow-molded, etc. with general-purpose equipment. As early as the 1930s, someone synthesized polyglycolide, used it as a raw material, made the first synthetic absorbable suture, and commercialized it in the field of medical materials. With the development of science and technology, polyglycolide h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/06A61L29/04A61L29/14
CPCA61L29/06A61L29/043A61L29/148C08L67/04C08L71/02C08L5/08
Inventor 胡何辉
Owner 胡何辉
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