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Preparation method and application of a spiramycin molecularly imprinted polymer on the surface of pine pollen

A technology of spiramycin and molecular imprinting, applied in chemical instruments and methods, other chemical processes, water/sludge/sewage treatment, etc., can solve the problems of endangering human health, spiramycin residues, etc., and achieve pesticide-free Residual, easy to control, single flower source effect

Inactive Publication Date: 2018-08-10
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since 1999, the European Union has banned spiramycin as a growth-promoting agent in animal feed [71]. my country has also clearly defined the use and dosage of spiramycin in the aquaculture industry, but spiramycin is still in the environment. There are residues in them, which are always endangering the health of human beings.

Method used

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  • Preparation method and application of a spiramycin molecularly imprinted polymer on the surface of pine pollen
  • Preparation method and application of a spiramycin molecularly imprinted polymer on the surface of pine pollen
  • Preparation method and application of a spiramycin molecularly imprinted polymer on the surface of pine pollen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Spiramycin 0.084g, MAA 0.04mL, dissolved in 20mL acetonitrile, stirred magnetically at room temperature for 4h; then added 0.2g pine pollen, 20mg AIBN, 0.3mL EGDMA, 30mL acetonitrile, 2 , magnetically stirred at 65°C for 24 hours; after the reaction was completed, the solid polymer was centrifuged, cleaned with absolute ethanol, dried at 50°C, and set aside. Spiramycin molecularly imprinted polymers (PP-MIPs) on the surface of pine pollen. Wrap part of the polymer with filter paper and put it into a Soxhlet extractor, wash off the spiramycin molecules with a mixed solution of anhydrous methanol / glacial acetic acid (V / V)=9:1-1:9, until the bottom extract Until the spiramycin molecule was not detected in the pine pollen, non-imprinted polymers (PP-NIPs) on the surface of pine pollen were obtained by drying at 50°C.

[0029] Table 1 is the specific surface area and average pore diameter of PP, PP-MIPs and PP-NIPs in Example 1. By comparison, it can be seen that the speci...

Embodiment 2

[0041] Spiramycin 0.084g, MAA 0.04mL, dissolved in 20mL acetonitrile, stirred magnetically at room temperature for 4h; then added 0.2g pine pollen, 20mg AIBN, 0.3mL EGDMA, 30mL acetonitrile, 2, magnetically stirred at 65° C. for 4 h; after the reaction was completed, the solid polymer was centrifuged, washed with absolute ethanol, dried at 50° C., and set aside. Spiramycin molecularly imprinted polymers (PP-MIPs) on the surface of pine pollen. Wrap part of the polymer with filter paper and put it into a Soxhlet extractor, wash off the spiramycin molecules with a mixed solution of anhydrous methanol / glacial acetic acid (V / V) = 1:9, until it cannot be detected in the extract below The non-imprinted polymers (PP-NIPs) on the surface of pine pollen were obtained by drying at 50°C.

Embodiment 3

[0043] Spiramycin 8.4g, MAA 4mL, dissolved in 2000mL acetonitrile, stirred magnetically at room temperature for 8h; then added 20g pine pollen, 2g AIBN, 30mL EGDMA, 30mL acetonitrile, 2 , magnetically stirred at 65°C for 24 hours; after the reaction was completed, the solid polymer was centrifuged, cleaned with absolute ethanol, dried at 50°C, and set aside. Spiramycin molecularly imprinted polymers (PP-MIPs) on the surface of pine pollen. Wrap part of the polymer with filter paper and put it into a Soxhlet extractor, and wash off the spiramycin molecule with a mixed solution of anhydrous methanol / glacial acetic acid (V / V) = 9:1 until it cannot be detected in the extract below The non-imprinted polymers (PP-NIPs) on the surface of pine pollen were obtained by drying at 50°C.

[0044] 2. In order to clarify the technical scheme and technical purpose of the present invention, the present invention will be further described below in conjunction with specific implementation examp...

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Abstract

The invention provides a preparation method and application of a pine pollen surface spiramycin molecularly imprinted polymer. The preparation method comprises the steps of firstly, adding spiramycin and MAA to acetonitrile, and conducting magnetic stirring at room temperature to obtain a mixed liquid A; secondly, adding pine pollen, AIBN and EGDMA to acetonitrile, evenly mixing AIBN, EGDMA and acetonitrile to obtain a mixed liquid B; adding the mixed liquid B to the mixed liquid A to obtain a mixed liquid C, introducing N2 into the mixed liquid C, completing a polymerization reaction under the condition of magnetic stirring at 65 DEG C, and then obtaining a solid polymer; thirdly, centrifuging the solid polymer obtained in the second step, sequentially conducting cleaning and drying, and then obtaining the pine pollen surface spiramycin molecularly imprinted polymer denoted as PP-MIPs. Pine pollen has the advantages of being abundant in source, single in flower source, stable in component and free of pesticide residues and zoohormones.

Description

technical field [0001] The invention relates to a preparation method and application of a spiramycin molecularly imprinted polymer on the surface of pine pollen, belonging to the technical field of preparation of environmental functional materials. Background technique [0002] Spiramycin (spiramycin, SAY) has a strong antibacterial effect in vivo and can enhance the phagocytosis of phagocytes. SAY is a macrolide antibiotic. Its antibacterial effect is worse than erythromycin, but it has a longer post-antibiotic effect (PAE). It can be used to treat ear and nose infections caused by Gram-positive bacteria and some Gram-negative bacteria. , Throat and Respiratory Tract Infections, so it is widely used in animal breeding. Due to the abuse of macrolide antibiotics with antibacterial effects such as spiramycin in the aquaculture industry, they enter the human body through the enrichment of the food chain, which will lead to allergic reactions and drug resistance in individual h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F222/14C08F220/06C08J9/26B01J20/26B01J20/30C02F1/28
CPCB01J20/268C02F1/285C08F222/1006C08F222/102C08J9/26C08J2201/0424C08J2335/02C08F220/06
Inventor 朱彦卓漆爱兵孙冬舒戴江栋闫永胜李春香
Owner JIANGSU UNIV
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