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Rod-shaped microcapsule using lactic acid-based polymer microparticle as template and preparation method thereof

A technology based on polymers and lactic acid, which is applied in the fields of medicine, beauty and skin care, and achieves the effects of simple operation, strong universality of the preparation process, and good biocompatibility

Active Publication Date: 2017-03-01
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, fibrous and rod-shaped particles of different sizes can be prepared by adjusting the preparation conditions by the emulsion solution evaporation method (ZL201010291154.2; Li, R.; Li, X.; Liu, L.; Zhou, Z.; Tang, H. ; Zhang, Q., Macromol.Rapid Commun.2010,31(22),1981-1986.), using this as a template to prepare rod-shaped polymer microcapsules under mild conditions with the LbL method, and adjust its geometry and mechanics The properties make it have better biological functions, and the research on better biomedical applications has not been reported

Method used

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  • Rod-shaped microcapsule using lactic acid-based polymer microparticle as template and preparation method thereof
  • Rod-shaped microcapsule using lactic acid-based polymer microparticle as template and preparation method thereof
  • Rod-shaped microcapsule using lactic acid-based polymer microparticle as template and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of PLGA microparticles with a molecular weight of 50,000 as a rod-shaped template:

[0030] Weigh 50 mg of polylactic acid-glycolic acid copolymer (50:50, molecular weight 50,000), add to 10 mL of dichloromethane and dissolve;

[0031] Add 0.736g sodium polyphosphate (STP) into 50mL aqueous solution with a mass concentration of 0.5% PVA (polymerization degree 550-650, alcoholysis degree 88%) and stir until dissolved;

[0032] Mix 10 mL of PLGA in dichloromethane with 50 mL of STP-containing PVA solution, stir at 800 rpm for two hours, centrifuge at 8,000 rpm, and wash with water to obtain a suspension of rod-shaped particles. The above-mentioned PLGA particle suspension was dropped on a silicon wafer and dried naturally.

[0033] Preparation of PLGA microparticles with rod-shaped template molecular weight 5,000:

[0034] Raw materials used: polylactic acid-glycolic acid copolymer (50:50, molecular weight 5,000) and other steps are the same as the preparati...

Embodiment 2

[0039] Preparation of PLA microparticles with a molecular weight of 50,000 as a rod-shaped template:

[0040] Weigh 50 mg of polylactic acid (molecular weight: 50,000), add to 10 mL of dichloromethane and dissolve;

[0041] Add 0.736 g of sodium polyphosphate (STP) into 50 mL of an aqueous solution with a mass concentration of 0.5% PVA (polymerization degree 550-650, alcoholysis degree 88%) and stir until dissolved.

[0042] Mix 10 mL of PLA in dichloromethane with 50 mL of STP-containing PVA solution, stir at 800 rpm for two hours, centrifuge at 8,000 rpm, and wash with water to obtain a suspension of rod-shaped particles. The above-mentioned PLA particle suspension was dropped on a silicon wafer and dried naturally.

[0043] Preparation of PLA microparticles with rod-shaped template molecular weight 5,000: raw materials: polylactic acid (molecular weight 5,000), and other steps are the same as the preparation of PLA microparticles with rod-shaped template molecular weight 5...

Embodiment 3

[0049] A preparation method of rod-shaped microcapsules with lactic acid-based polymer particles as a template, comprising the steps of:

[0050] Mix the PAH (molecular weight 17,500) solution with a concentration of 2 mg / mL and the rod-shaped template PLGA particles (molecular weight 5,000) to obtain a mixed solution 1, so that the concentration of the rod-shaped template particles in the mixed solution 1 is 10 8 / mL; the solvent of the PAH solution is 0.5M NaCl aqueous solution; Rotate and mix for 30min, centrifuge, remove the supernatant, wash with 0.5M NaCl aqueous solution, and centrifuge to obtain the first particle; mix the first particle with a concentration of 2mg / mL of PSS (molecular weight 80,000) solution was mixed to obtain mixed solution 2, the volume of mixed solution 2 was equal to the volume of mixed solution 1, and the solvent of the PSS solution was 0.5M NaCl aqueous solution; rotate and mix for 30min, centrifuge, remove The supernatant was washed with 0.5M ...

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Abstract

The invention discloses a rod-shaped microcapsule using a lactic acid-based polymer microparticle as a template and a preparation method thereof. The preparation method comprises (1) mixing a positively charged polymer solution and rod-shaped template lactic acid-based polymer particles to obtain a mixed liquid 1, carrying out centrifugation, removing the supernatant, and carrying out washing and centrifugation to obtain first microparticles, mixing the first microparticles and a negatively charged polymer solution to obtain a second solution 2, and carrying out centrifugation and washing to obtain second microparticles, (2) repeating the step (1), and (3) adding a glutaraldehyde aqueous solution into the microparticles obtained by the step (2), carrying out crosslinking, and carrying out centrifugation and washing to obtain final microparticles, dissolving the lactic acid-based polymer in the final microparticles, and carrying out washing to obtain shell-controllable rod-shaped microcapsules using lactic acid-based polymer microparticles as templates. The rod-shaped microcapsule can carry functional components such as biomacromolecule drugs. The method of the invention has the advantages of easy control of a shape and simple operation. The rod-shaped microcapsule has good biocompatibility, biodegradability and no immunogenicity.

Description

technical field [0001] The invention belongs to the fields of medicine, beauty and skin care, and in particular relates to a rod-shaped microcapsule with lactic acid-based polymer particles as a template, a preparation method and application thereof. Background technique [0002] The uptake and internalization of the carrier are closely related to its function or escape from the clearance system, which affects its application in the field of biomedicine. The size, shape, rigidity and surface chemical modification of particles all affect the biological properties of the carrier, and it is very important to rationally prepare drug carriers with different physical and chemical properties. The aspect ratio is an important parameter in carrier design, and adjusting the aspect ratio can improve the biodistribution and tumor penetration of the material. In the study of multiple systems, it was found that the aspect ratio affects the internalization behavior of cells to the carrier...

Claims

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Application Information

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IPC IPC(8): A61K8/85A61K8/11A61Q19/00
CPCA61K8/11A61K8/85A61Q19/00
Inventor 杜博周志敏张其清刘睿
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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