Particle controllable preparation method and device based on ultrasonic auxiliary continuous anti-solvent film dialysis process

An ultrasonic-assisted, anti-solvent technology, applied in the field of continuous controllable preparation of particles, can solve the problems of particle agglomeration and uneven particle size, and achieve the effects of improving dispersibility, reducing residues and good dispersibility.

Active Publication Date: 2017-03-22
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a continuous particle preparation method with simple operation, good particle dispersibility, controllable particle size and narrow particle size distribution in view of the shortcomings of particle agglomeration, uneven particle size and batch preparation process control in the existing particle preparation technology

Method used

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  • Particle controllable preparation method and device based on ultrasonic auxiliary continuous anti-solvent film dialysis process
  • Particle controllable preparation method and device based on ultrasonic auxiliary continuous anti-solvent film dialysis process
  • Particle controllable preparation method and device based on ultrasonic auxiliary continuous anti-solvent film dialysis process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～11

[0046] A preparation method of zein microspheres, comprising the following steps:

[0047] (1) Prepare ethanol solvents with different volume fractions according to Table 1, and place them in the second sealed container 4; select ethanol solvents with different volume fractions according to Table 1, and prepare 250 mL of zein solutions with different concentrations for use.

[0048] (2) Ultrapure water is used as an anti-solvent, placed in the first sealed container 1; the ultrapure water enters the shell side of the membrane module 5 through the first peristaltic pump 2, and the flow rate is the shell side flow rate corresponding to Examples 1-11 in Table 1.

[0049] (3) Step (1) The ethanol solvent placed in the second sealed container 4 passes through the second peristaltic pump 3 into the tube side of the membrane module 5, and the flow rate is the tube side flow rate corresponding to Examples 1-11 in Table 1.

[0050] (4) Turn on the ultrasonic generator 6, and set the ul...

Embodiment 13～22

[0062] A preparation method for curcumin granules, comprising the following steps:

[0063] (1) Configure ethanol solvents with different volume fractions according to Table 2, and place them in the second sealed container 4; select ethanol solvents with different volume fractions according to Table 2, and prepare 250 mL of curcumin solutions with different concentrations for subsequent use.

[0064] (2) Ultrapure water is used as an anti-solvent, placed in the first sealed container 1; the ultrapure water enters the shell side of the membrane module 5 through the first peristaltic pump 2, and the flow rate is the shell side flow rate corresponding to Examples 13-22 in Table 2.

[0065] (3) Step (1) The ethanol solvent placed in the second sealed container 4 passes through the second peristaltic pump 3 into the tube side of the membrane module 5, and the flow rate is the tube side flow rate corresponding to Examples 13-22 in Table 2.

[0066] (4) Turn on the ultrasonic generat...

Embodiment 24～29

[0079] A preparation method of zein microspheres loaded with curcumin, comprising the following steps:

[0080] (1) Prepare ethanol solvents with different volume fractions according to Table 3, and place them in the second sealed container 4; select ethanol solvents with different volume fractions according to Table 3, and prepare 250 mL of zein solutions with different concentrations for use.

[0081] (2) According to Table 3, the curcumin powder was dispersed into the zein solution according to different drug loading ratios to prepare a raw material solution for use.

[0082] (3) Ultrapure water is used as an anti-solvent, placed in the first sealed container 1; the ultrapure water enters the shell side of the membrane module 5 through the first peristaltic pump 2, and the flow rate is the shell side flow rate corresponding to Examples 24-29 in Table 3.

[0083] (4) Step (1) The ethanol solvent placed in the second sealed container 4 passes through the second peristaltic pu...

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Abstract

The invention discloses a particle controllable preparation method and device based on an ultrasonic auxiliary continuous anti-solvent film dialysis process. A first sealed container of the device is connected with a first peristaltic pump. The first peristaltic pump is connected with a lower end connector of a film module shell pass. A fourth sealed container is connected with an upper end connector of the film module shell pass. A second sealed container is connected with a second peristaltic pump. The second peristaltic pump is connected with a lower end connector of a film module tube pass. Hollow fiber film bundles in a film module form a tubular structure, the tube pass of the film module is formed, and the space between the hollow fiber bundles and a film module shell forms the shell pass of the film module. By the adoption of the ultrasonic auxiliary continuous operation film module, the anti-solvent and solvent on the two sides of a film are controlled to penetrate towards the opposite sides correspondingly, raw materials are promoted to be separated out of a solution, and particle growth and dispersion are adjusted and controlled through dynamic dialysis and ultrasound enhancing, so that particles which are controllable in particle size, narrow in particle size distribution and good in dispersity are prepared efficiently, and the preparation method and device can be used for preparing various oral preparations or can be used for further processing of injections.

Description

technical field [0001] The invention relates to a continuous particle controllable preparation technology, in particular to a particle controllable preparation method and device based on an ultrasonic-assisted continuous anti-solvent membrane dialysis process. Background technique [0002] As a key link in obtaining products, the improvement and development of particle preparation technology has always been a research hotspot, especially in the field of pharmaceuticals. Experimental and clinical studies have found that the microstructure of drug particle size, morphology and polymorphism has a crucial impact on drug efficacy; loading active ingredients of drugs in the carrier material to prepare a drug delivery system can reduce drug side effects and improve drug efficacy. The stability of drugs and the realization of drug controlled release and targeted delivery. [0003] The preparation methods of drug granules mainly include media grinding method, high pressure homogeniz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D61/28B01D61/32B01D61/30B01D61/24B01J13/02B01J2/00
Inventor 江燕斌冯嘉玲刘贵金关国强李炳辉
Owner SOUTH CHINA UNIV OF TECH
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