A kind of preparation method of monodisperse large particle diameter polymer microsphere
A dispersion polymerization and large particle size technology, which is applied in the field of preparation of new monodisperse large particle size polymer microspheres, can solve the problems of low separation efficiency and complicated preparation procedures, and achieve good biocompatibility, simple preparation procedures, The effect of uniform size distribution
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Embodiment 1
[0029] Take a 250ml three-necked flask equipped with reflux condenser, mechanical stirring and nitrogen venting device, first add a mixed solvent consisting of 64g methanol and 16g ultrapure water, then add 2g PVPk30, 20g styrene and 0.32g AIBN, mechanically stir to make it Dissolve, heat in a water bath to 70°C under the protection of nitrogen, and react at a constant temperature for 24 hours to obtain a white emulsion. The product was centrifuged, washed three times with ethanol and dried to obtain PS microspheres.
[0030] In addition, add 80ml ultrapure water, 0.25g PVPk30, 0.038g KPS and 5g PEGMA to a 250ml three-necked flask 360 , Stir and dissolve uniformly, disperse 1g of PS microspheres in 20ml of ultrapure water to form an emulsion, then add it to the above aqueous solution and stir evenly, stirring continuously to swell the seed microspheres for 1 hour. Then under the protection of nitrogen, the temperature in a water bath is heated to 70°C, and the reaction is kept at...
Embodiment 2
[0034] First, PS microspheres were prepared according to the same steps as in Example 1. Then add 80ml liquid paraffin, 0.25g Span 80, 0.023g AIBN and 5g PEGMA into a 250ml three-necked flask 360 , Stir and dissolve uniformly, disperse 1g of PS microspheres in 20ml of liquid paraffin to form an emulsion, then add it to the above aqueous solution and stir evenly, stirring constantly to swell the seed microspheres for 1 hour. Then, under the protection of nitrogen, the temperature in a water bath was heated to 70°C, and the reaction was performed at a constant temperature for 6 hours. Finally, the product was centrifuged, washed three times with ethanol and dried to obtain a sample of PPEGMA microspheres.
Embodiment 3
[0036] Take a 250ml three-necked flask equipped with reflux condenser, mechanical stirring and nitrogen venting device, first add 90g ethanol, then add 2g PVPk30, 10g methyl methacrylate and 0.164g AIBN, mechanically stir to dissolve, and water bath under nitrogen protection Heat to 70°C and react at constant temperature for 24 hours to obtain a white emulsion. The product was centrifuged, washed three times with ethanol and dried to obtain PMMA microspheres.
[0037] In addition, add 80ml ultrapure water, 0.25g PVPk30, 0.038g KPS and 5g PEGMA to a 250ml three-necked flask 360 , Stir and dissolve uniformly, disperse 1g of PMMA microspheres in 20ml of ultrapure water to form an emulsion, then add it to the above aqueous solution and stir evenly, stirring continuously to swell the seed microspheres for 1 hour. Then under the protection of nitrogen, the temperature in a water bath is heated to 70°C, and the reaction is kept at a constant temperature for 6 hours. Finally, the produc...
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