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Bactericidal aseptic solid medical ultrasonic coupling patch and preparation method thereof

An ultrasonic coupling and sterilization technology, applied in the field of biomedicine, can solve the problems of skin and mucous membrane allergic reactions, damage to the probe, affect the quality of ultrasonic images, etc. Effect

Active Publication Date: 2017-04-26
广东速康特医食品科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polyhexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, etc. belong to cationic surfactants. Antimicrobials can damage transducers or affect the quality of ultrasound images
Methyl and propyl paraben antibacterial preservatives are effective against molds and yeasts, but often cause allergic reactions to the skin and mucous membranes

Method used

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  • Bactericidal aseptic solid medical ultrasonic coupling patch and preparation method thereof
  • Bactericidal aseptic solid medical ultrasonic coupling patch and preparation method thereof
  • Bactericidal aseptic solid medical ultrasonic coupling patch and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] The preparation of embodiment 1 modified bletilla striata polysaccharide

[0041] (1) Get bletilla striata tubers, remove impurities, wash and dry, pulverize, pass through a 60-mesh sieve, add 4 times the mass of bletilla striata powder and soak in ethanol with a volume fraction of 95% for 4 hours, filter off ethanol, and wash bletilla striata powder with deionized water 2 Add 10 times the mass of bletilla striata powder in deionized water and extract by ultrasonic for 2 hours at a temperature of 60°C; add complex protease with a mass of 7‰ of bletilla striata powder, and extract for 3 hours at a temperature of 60°C and a pH of 6.5. Filter to remove the filter residue, and then filter the filtrate twice with diatomaceous earth and activated carbon compound as filter aid. After the final filtration, the filtrate is refrigerated and centrifuged at 8000r / min 4°C for 10min, and the supernatant is taken and concentrated under reduced pressure to the original volume. 1 / 3, add...

Embodiment 3

[0051] Example 3 Bactericidal aseptic solid-state medical ultrasonic coupling patch and its preparation

[0052] The sterilization type aseptic solid-state medical ultrasonic coupling patch of this embodiment is composed of the following components in terms of mass percentage: karaya gum 1.0%, modified bletilla striata polysaccharide 1.7% obtained in Example 1, carboxymethyl chitosan 2.5%, 0.1% of housefly antimicrobial peptide, 0.05% of luteolin, 1% of propylene glycol, 0.05% of alkyl glycoside, 0.2% of pullulan, and the balance is deionized water.

[0053] Preparation:

[0054] S1: Take karaya gum, add deionized water to stir and mix well, and ultrasonically treat for 30 minutes at a temperature of 30°C and a power of 70W, then add modified Bletilla striata polysaccharide, carboxymethyl chitosan, housefly antimicrobial peptide, Luteolin, propylene glycol, alkyl glycosides and pullulan are fully stirred and dissolved to obtain a mixed solution;

[0055] S2: Adjust the pH of...

Embodiment 4

[0056] Example 4 Bactericidal aseptic solid-state medical ultrasonic coupling patch and its preparation

[0057] The sterilization type sterile solid-state medical ultrasonic coupling patch of this embodiment is composed of the following components in terms of mass percentage: karaya gum 0.7%, modified bletilla striata polysaccharide 1.6% obtained in Example 1, carboxymethyl chitosan 2.3%, 0.05% of housefly antimicrobial peptide, 0.1% of luteolin, 0.4% of propylene glycol, 0.1% of alkyl glycoside, 0.4% of pullulan, and the balance is deionized water.

[0058] Preparation:

[0059] S1: Take karaya gum, add deionized water to stir and mix well, and ultrasonically treat for 30 minutes at a temperature of 30°C and a power of 70W, then add modified Bletilla striata polysaccharide, carboxymethyl chitosan, housefly antimicrobial peptide, Luteolin, propylene glycol, alkyl glycosides and pullulan are fully stirred and dissolved to obtain a mixed solution;

[0060] S2: Adjust the pH o...

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Abstract

The invention belongs to the technical field of biological medicine, and relates to bactericidal aseptic solid medical ultrasonic coupling patch and a preparation method thereof. The patch is prepared from, by weight percentage, 0.3-1.0% of karaya gum, 1.2-1.8% of modified bletilla striata polysaccharide, 1.6-2.5% of carboxymethyl chitosan, 0.01-0.1% of musca domestica antibacterial peptide, 0.05-0.2% of luteolin, 1-5% of propanediol, 0.05-0.2% of alkyl glycoside, 0.2-0.8% of Pullulan and the balancedeionized water. The bactericidal aseptic solid medical ultrasonic coupling patch complies with the aseptic regulation stipulated in <Pharmacopoeia of People's Republic of China>, at the same time possesses excellent acoustic performance, a good ultrasonic conduction effect, clear ultrasonoscopy, high resolution, good biocompatibility, reliable disinfection efficacy and a stable physicochemical property.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a sterilized aseptic solid-state medical ultrasonic coupling patch and a preparation method thereof. Background technique [0002] With the advancement of medical diagnostic technology, the use of ultrasonic diagnosis and medical ultrasonic gel is becoming more and more common. Medical ultrasonic coupling agent is an intermediary medium for transmitting sound waves that is filled or applied between the skin-mucosa and the radiating surface of the probe (or treatment head) during ultrasonic diagnosis and treatment operations. The quality of medical ultrasound gels is closely related to the quality of ultrasound images. Poor quality medical ultrasound gels can cause loss of ultrasound energy, lower resolution, blurred images, and irritate the skin and damage the probe. [0003] At present, the clinically used medical ultrasonic coupling agent is a water-based polym...

Claims

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Application Information

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IPC IPC(8): A61K49/22A01N43/16A01N43/36A01N47/44A01P1/00A01P3/00C08B37/00
CPCA01N43/16A01N43/36A01N47/44A61K49/22C08B37/0003
Inventor 胡波宋雨润王英男王志吉万柏钢
Owner 广东速康特医食品科技有限公司
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