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Functionalized nano biological ceramic coating and preparation process thereof

A technology of bioceramics and preparation technology, which is applied in the field of medical materials, can solve the problems that the bonding strength needs to be further improved, and achieve the effects of accelerating the repair and healing rate, improving the bonding strength, and good biocompatibility

Inactive Publication Date: 2017-04-26
苏州纳贝通环境科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the functionalization of the ceramic coating can also be realized by changing the composition of the ceramic coating, which is flexible to use, but the bonding strength between the ceramic coating and the metal substrate usually needs to be further improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A functionalized nano-biological ceramic coating is prepared from the following components by weight: 15 parts of tricalcium phosphate, 3 parts of chromium sulfate, 1 part of strontium fluorophosphate, 1 part of aluminum chloride, and 1.3 parts of sodium metatitanate , 0.6 part of ammonium molybdate, 0.3 part of silica gel, 0.5 part of chitosan fiber, 1 part of carbon molecular sieve-220, 1.2 part of carboxymethyl chitin, 0.3 part of polyhydroxybutyric acid, 0.8 part of acetylglutamic acid, tartaric acid 0.6 part, 1.1 part of cellulose acetate, 0.4 part of 3-acrylamido dopamine, 0.1 part of methyl salicylate, 0.1 part of eucalyptol, 0.8 part of urea, 0.3 part of Span-80, and 64 parts of distilled water.

[0021] Wherein, the silicone gel is aminopropyl silicone oil.

[0022] A preparation process of a functionalized nano-bioceramic coating, comprising the following steps:

[0023] Step 1. The implant material is first subjected to plasma treatment, and then the treated...

Embodiment 2

[0028] A functionalized nano-biological ceramic coating is prepared from the following components by weight: 27 parts of tricalcium phosphate, 9 parts of chromium sulfate, 4 parts of strontium fluorophosphate, 6 parts of aluminum chloride, and 2.8 parts of sodium metatitanate , 1.5 parts of ammonium molybdate, 2 parts of silica gel, 1.7 parts of chitosan fiber, 3 parts of carbon molecular sieve-220, 3.8 parts of carboxymethyl chitin, 1.2 parts of polyhydroxybutyric acid, 2 parts of acetylglutamic acid, tartaric acid 2.4 parts, 3 parts of cellulose acetate, 1.5 parts of 3-acrylamido dopamine, 0.7 parts of methyl salicylate, 0.5 parts of eucalyptol, 1.7 parts of urea, 1.4 parts of Span-80, 77 parts of distilled water.

[0029] Wherein, the silicone gel is a mixture of hydroxy-terminated methyl silicone oil and methyl vinyl silicone oil, and the mass ratio of the two is 2:3.

[0030] A preparation process of a functionalized nano-bioceramic coating, comprising the following steps...

Embodiment 3

[0036] A functionalized nano-biological ceramic coating is prepared from the following components by weight: 17 parts of tricalcium phosphate, 3.4 parts of chromium sulfate, 1.2 parts of strontium fluorophosphate, 1.6 parts of aluminum chloride, and 1.4 parts of sodium metatitanate , 0.8 part of ammonium molybdate, 0.4 part of silica gel, 0.6 part of chitosan fiber, 1.3 part of carbon molecular sieve-220, 1.4 part of carboxymethyl chitin, 0.4 part of polyhydroxybutyric acid, 0.9 part of acetylglutamic acid, tartaric acid 0.8 part, 1.5 part of cellulose acetate, 0.6 part of 3-acrylamido dopamine, 0.2 part of methyl salicylate, 0.1 part of eucalyptol, 0.9 part of urea, 0.5 part of Span-80, 68 parts of distilled water.

[0037] Wherein, the silicone gel is a mixture of aminopropyl silicone oil and hydroxy-terminated methyl silicone oil, and the mass ratio of the two is 1:4.

[0038] A preparation process of a functionalized nano-bioceramic coating, comprising the following steps:...

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PUM

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Abstract

The invention discloses a functionalized nano biological ceramic coating and a preparation process thereof. The functionalized nano biological ceramic coating is prepared from the following components: tricalcium phosphate, chromium sulfate, strontium fluorapatite, aluminum chloride, sodium metatitantate, ammonium molybdate, silica gel, chitosan fibers, carbon molecular sieve-220, carboxymethyl chitin, polyhydroxybutyric acid, acetylglutamic acid, tartaric acid, cellulose acetate, 3-acrylamide dopamine, methyl salicylate, eucalyptol, urea, span-80 and distilled water. The biological ceramic coating provided by the invention is significantly high in bonding intensity with an implant, and the maximum bearing load of the biological ceramic coating reaches 105-127N or above, so that a demand on the mechanical performance of the coating of the implant is satisfied; and in addition, the coating is excellent in biocompatibility, and the coating is capable of promoting the adhesion and growth of osteoblast, accelerating repair and healing rates and shortening a healing cycle.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a functionalized nano-biological ceramic coating and a preparation process thereof. Background technique [0002] Biomedical materials are new high-tech materials used for organisms to diagnose, repair and replace their damaged tissues, organs or enhance their properties. With the continuous progress of new medical technologies and major breakthroughs in key science and technology, biomaterials have gradually become one of the hottest materials for global scientists and related scholars to research and develop. [0003] At present, titanium and titanium alloy implants have been widely used in biomedical materials for bone repair. However, due to their own biological inertness, the rate of bone healing is affected. Usually, in order to improve the implantation success rate of titanium and titanium alloy implants, the surface of the implants is often modified...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/30
CPCA61L27/50A61L27/306A61L2420/02A61L2420/06A61L2430/02
Inventor 潘明华
Owner 苏州纳贝通环境科技有限公司
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