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Skin burn repair material and preparing method thereof

A technology for repairing materials and skin, applied in the field of biomedicine, can solve problems such as repairing materials that cannot meet clinical requirements, and achieve good biocompatibility, simple equipment and process, and good repeatability

Inactive Publication Date: 2017-04-26
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the continuous development of medical level and the continuous improvement of people's requirements for dressings, traditional repair materials can no longer meet clinical requirements.

Method used

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  • Skin burn repair material and preparing method thereof
  • Skin burn repair material and preparing method thereof
  • Skin burn repair material and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]Blend polylactic acid and polyvinylpyrrolidone (mass ratio 7:1) into DCM and THF mixed solvent (mass ratio DCM / THF = 2:1) to prepare a blend solution with a mass fraction of 10%, and add Nano-silver (mass ratio is macromolecule / nanometer silver=200:1, said macromolecule includes polylactic acid and polyvinylpyrrolidone), mechanically stirred at 400 r / min for 6h, mixed evenly to form mixed spinning solution one; gelatin and dexamethasone (mass ratio: 300:1) were added to HFIP (hexafluoroisopropanol) to prepare a blend solution with a mass fraction of 9%, mechanically stirred at 300 r / min for 24 h, and mixed uniformly to form a mixed solution. Spinning Solution II. A coaxial electrospinning device was used to carry out coaxial electrospinning with the first spinning solution as the shell layer and the second spinning solution as the core layer. The relative humidity was 99%, the ambient temperature was 55°C, and the positive spinning voltage was 20 kV. , a flat-plate coll...

Embodiment 2

[0041] Polylactic acid and Panax notoginseng saponins hydrochloride (mass ratio: 10:1) were added to DMF to prepare a blend solution with a mass fraction of 35%, mechanically stirred at 100 r / min for 48 h, and mixed uniformly to form a blended solution. Spinning solution one. Polycaprolactone and polyethylene glycol (mass ratio: 5:1) were blended into THF to prepare a blend solution with a mass fraction of 10%, and fibroblast growth factor (FGF) (mass ratio: Polymer / FGF=1000:1, the polymer includes polylactic acid, polycaprolactone and polyethylene glycol), mechanically stirred at 800 r / min for 2 h, and mixed evenly to form mixed spinning solution 2. A coaxial electrospinning device was used to carry out coaxial electrospinning with spinning mixed solution 1 as the shell layer and spinning mixed solution 2 as the core layer. The relative humidity was 15%, the ambient temperature was 15°C, and the positive spinning voltage was 40 kV, using a flat-plate spinning device, a groun...

Embodiment 3

[0043] Collagen and chitosan (mass ratio 4:1) were blended into hexafluoroisopropanol to prepare a blend solution with a mass fraction of 11%, and the crude extract of Garcinia cambogia (mass ratio of high molecular weight / Garcinia cambogia crude extract=400:1, the macromolecules include collagen and chitosan), mechanically stirred at 350 r / min for 48 h, mixed evenly to form mixed spinning solution 1; polyethylene glycol was added to DMAC (N,N-dimethylacetamide) and CHCl 3 Mixed solvent (mass ratio DMAC / CHCl 3 = 1:4) to prepare a blend solution with a mass fraction of 8 %, mechanically stirred at a speed of 300 r / min for 18 h, and mixed evenly to form a mixed spinning solution II. A coaxial electrospinning device was used to carry out coaxial electrospinning with the first spinning solution as the shell layer and the second spinning solution as the core layer. The relative humidity was 80%, the ambient temperature was 35 °C, and the spinning voltage was 20 kV. A flat-plate...

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Abstract

The invention discloses a skin burn repair material and a preparing method thereof, and belongs to the field of biomedicine. A functional loading substance is added into a polymer to prepare the repair material through the coaxial electrostatic spinning process, and the upper surface layer micro-nano structure is adjusted so that the repair material can resist adhesion of outside microorganisms and bacteria. The prepared repair material containing the functional loading substance with antibacterial, antiphlogistic and repair promoting functions repairs the skin burn area in a targeted mode based on the characteristics of different stages of the burnt skin repair process. The adopted base material has high biocompatibility, secondary damage to the wound region of traditional medical gauze when fresh dressing is changed for a wound is avoided, and secondary infection caused by external factors can be effectively resisted. The skin burn repair material and the preparing method thereof can be effectively applied to biomedicine related fields and have the possibility of extensive clinic application.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a skin burn repair material and a preparation method thereof. Background technique [0002] The skin is the largest organ in the human body and plays a key role in regulating body temperature, defending against microorganisms and retaining moisture. Normal healthy skin is a human organ with complex structure and active metabolism. The skin is composed of three parts: epidermis, dermis and subcutaneous tissue. In daily life, burns are a common factor causing skin defects and abnormalities, which bring inconvenience and great psychological pressure to patients. Burn repair of the skin is a complex biological process. Traditionally, burn repair is divided into three phases, namely, inflammatory response phase, tissue formation phase, and matrix reconstruction phase; these three phases overlap each other in time. The healing process is not only related to the patient's own co...

Claims

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Application Information

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IPC IPC(8): A61L27/60A61L27/54A61L27/22A61L27/50D04H1/728D01D5/00
CPCA61L27/22A61L27/50A61L27/54A61L27/60A61L2300/404A61L2300/412A61L2300/414D01D5/0038D01D5/0069D01D5/0076D01D5/0092D04H1/728
Inventor 王林格李卫昌朱玥
Owner SOUTH CHINA UNIV OF TECH
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