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Phloretin orally disintegrating tablet and preparation method thereof

A technology for phloretin and orally disintegrating tablets, applied in the field of phloretin orally disintegrating tablets and their preparation, can solve problems such as inconvenient administration, and achieve the effects of improving solubility and biological activity, light weight and fast absorption

Inactive Publication Date: 2017-05-10
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Specifically, the present invention provides a pharmaceutical dosage form that can be rapidly disintegrated in the oral cavity to overcome the problems of inconvenient administration of phloretin as a tablet.

Method used

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  • Phloretin orally disintegrating tablet and preparation method thereof
  • Phloretin orally disintegrating tablet and preparation method thereof
  • Phloretin orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1 prepares phloretin orally disintegrating tablet

[0054] Prescription quantity (1000 tablets): phloretin solid dispersion 50g (phloretin: PVP K-30 = 1:9, weight ratio), microcrystalline cellulose 30g, direct-pressed starch 80g, crospovidone CL -SF 130g, lemon flavor 2.5g, turmeric 2.5g, magnesium stearate 5g.

[0055] Preparation of phloretin solid dispersion: Accurately weigh the prescribed amount of phloretin and PVP K-30 (weight ratio 1:9) and place in a beaker, add an appropriate amount of absolute ethanol to dissolve it completely, stir at room temperature for 3 hours, and place at 50 °C to remove ethanol by rotary evaporation under reduced pressure, vacuum-dry at 60 °C for 3 hours, and pulverize through a 100-mesh sieve to obtain a solid dispersion of phloretin.

[0056] Preparation of orally disintegrating phloretin tablets: Weigh the phloretin solid dispersion, disintegrant, microcrystalline cellulose, direct-pressed starch, lemon flavor and magnes...

Embodiment 2

[0057] Embodiment 2 prepares phloretin orally disintegrating tablet

[0058] Prescription amount (1000 tablets): Phloretin solid dispersion 200g (phloretin: PVP K-30=1:1, weight ratio), xylitol (filler) 15g, croscarmellose sodium (Disintegrant) 75g, polyethylene glycol (lubricant) 4000 5g, 5% PVP-K30 ethanol solution (equivalent to 5g PVP-K30).

[0059] Preparation of phloretin solid dispersion: Precisely weigh the prescribed amount of phloretin and PVP K-30 (weight ratio 1:1) and place in a beaker, add an appropriate amount of 80% ethanol to completely dissolve it, stir at 40°C for 2 hours, and spray dry Phloretin solid dispersion was obtained.

[0060] Preparation of orally disintegrating phloretin tablets: the dispersion and auxiliary materials are pre-passed through a 100-mesh sieve. Take by weighing 180g phloretin solid dispersion, xylitol and 60g croscarmellose sodium by the prescription composition in the table and mix homogeneously, 5%PVP-K30 ethanol solution granula...

Embodiment 3

[0061] Embodiment 3 prepares phloretin orally disintegrating tablet

[0062] Prescription amount (1000 tablets): phloretin inclusion complex 100g (phloretin: HP-β-CD = 1:1, molar ratio, equivalent to phloretin 16g), cross-linked sodium carboxymethyl starch (disintegrated solution) 100g, maltitol (filler) 75g, menthol (flavor) 5g, magnesium stearate (lubricant) 12g, 8% PVP-K30 ethanol solution (equivalent to 8g PVP-K30).

[0063] Preparation of phloretin inclusion compound: mix phloretin, menthol and inclusion material HP-β-CD (phloretin:HP-β-CD molar ratio 1:1), add appropriate amount of absolute ethanol to make it completely Dissolve, stir at room temperature for 3 hours, remove ethanol by rotary evaporation under reduced pressure at 40°C, dry in a vacuum oven at 50°C for 4h, and pulverize through a 100-mesh sieve to obtain the phloretin inclusion compound.

[0064] Preparation of orally disintegrating phloretin tablets: all auxiliary materials are pre-passed through a 100-m...

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Abstract

The invention relates to the field of health food, and discloses a phloretin orally disintegrating tablet and a preparation method thereof. The phloretin orally disintegrating tablet contains the following ingredients by weight percent: 2.5-85% of phloretin solid dispersion, 2-80% of a filler, 2-20% of a disintegrating agent, 0-25% of a bitter taste masking agent, 0.1-7.5% of a lubricating agent and 0-10% of an adhesive, and the total weight of the ingredients is 100%. The invention also discloses a preparation method of the phloretin orally disintegrating tablet. The preparation method comprises the following steps: sieving the phloretin solid dispersion, the filler, the disintegrating agent, the bitter taste masking agent and the adhesive, mixing the ingredients according to an equivalent progressive increase principle, and then adding the lubricating agent, and mixing uniformly; and carrying out a direct powder compression method, and carrying out tabletting by adopting a round die to obtain the phloretin orally disintegrating tablet. The phloretin orally disintegrating tablet disclosed by the invention can be rapidly disintegrated in the mouth so as to be absorbed quickly, is high in biological activity and utilization ratio, and convenient to carry and transport, and can be stored for a long time.

Description

technical field [0001] The invention relates to the field of health food, in particular to an orally disintegrating phloretin tablet and a preparation method thereof. Background technique [0002] Phloretin (phloretin) is a natural plant compound containing dihydrochalcones, chemical name: trihydric phenol acetone 2,4,6-trihydroxy-3-(4-hydroxyphenyl)propiophenone. Under normal conditions, it is a light yellow to pure white needle-like crystal, which is hygroscopic and decomposes at 262°C. It is easily soluble in various organic solvents such as ethanol and acetone, and slightly soluble in water. The solubility in water is only 0.02mg. mL -1 . [0003] Phloretin is mainly derived from the roots and peels of succulent fruit plants such as pears, apples, and strawberries. A small amount of phloretin is also contained in the juices of various vegetables. Phloretin is widely known for its whitening, anti-acne, anti-mutagenic and other activities in food, and in cosmetics as a ...

Claims

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Application Information

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IPC IPC(8): A23L33/105A23P10/28
Inventor 何燕林惠琼陈喜财林蕴江曾银杰江森韩雷程书朋武文敬张焜郑希
Owner GUANGDONG UNIV OF TECH
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