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Multifunctional high-strength gel and preparation method thereof

A multi-functional, high-strength technology, applied in the fields of biomaterials, tissue engineering and polymer materials, can solve the problems of poor mechanical properties of gels, functional inertness, narrow application range, etc., and achieve simple and quick preparation methods, mild conditions, The effect of high practical application value

Inactive Publication Date: 2017-05-10
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a high-strength multifunctional hydrogel to overcome the defects of poor mechanical properties, single function or even functional inertness of traditional gels, and narrow application range

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Preparation of ionic liquids (ILs)

[0021] Glycine (Gly) and choline (Ch) were dissolved in 5 mL of ionized water at a molar ratio of 1.05:1, respectively, and the choline (Ch) solution was slowly added to the glycine (Gly) solution at 3°C ​​with a constant pressure dropping funnel. Magnetic stirring reaction for 48 hours; after the reaction was completed, the water was removed by rotary evaporation at 60°C, and then excess ethanol was poured into the above reaction system to remove unreacted glycine; the reaction product was vacuum-dried at 50°C to remove residual ethanol and water, Obtain pure choline-glycine (Ch-Gly) ionic liquid.

[0022] (2) Modification of ionic liquids (ILs)

[0023] Dissolve acrylic acid (AAc) in 10ml of distilled water, add N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), stir magnetically at room temperature After 2h, add the Ch-Gly ionic liquid obtained in step (1) to continue the reaction for 24h, s...

Embodiment 2

[0027] (1) Preparation of ionic liquids (ILs): same as Example 1.

[0028] (2) Modification of ionic liquids (ILs): same as Example 1.

[0029] (3) Preparation of functionalized high-strength gel

[0030] Dissolve NIPAAm, Ch-Gly-AAc, and sodium alginate (Alg) in deionized water with a solid content of 10%, and the mass ratio of the three is NIPAAm:Ch-Gly-AAc:Alg=6:3:1, while stirring Bound nitrogen protection 10min, then add chemical cross-linking agent MBAA, MBAA / (NIPAAm+Ch-Gly-AAc)=1wt%, after continuing nitrogen protection reaction for 20min, add initiator 0.1wt% potassium persulfate (KPS) aqueous solution, 10wt% ionic crosslinker CaSO 4 Aqueous solution, under the protection of nitrogen, react for about 20min, and turn off the nitrogen. Pour the reaction product into a mold, add 2-3 drops of 2% TEMED dropwise, and react at room temperature for 24 hours to obtain a gel product, soak and wash the obtained gel with deionized water to remove unreacted monomers.

Embodiment 3

[0032] (1) Preparation of ionic liquids (ILs): same as Example 1.

[0033] (2) Modification of ionic liquids (ILs): same as Example 1.

[0034](3) Preparation of functionalized high-strength gel

[0035] Dissolve NIPAAm, Ch-Gly-AAc, and sodium alginate (Alg) in deionized water with a solid content of 10%, and the mass ratio of the three is NIPAAm:Ch-Gly-AAc:Alg=3:1:1, while stirring Pass nitrogen protection for 10min, then add chemical crosslinking agent MBAA, MBAA / (NIPAAm+Ch-Gly-AAc)=0.1wt%, continue nitrogen protection reaction for 20min, add initiator 0.1wt% potassium persulfate (KPS) aqueous solution , 5wt% ionic crosslinker CaSO 4 Aqueous solution, under the protection of nitrogen, react for about 20min, and turn off the nitrogen. Pour the reaction product into a mold, add 2-3 drops of 2% TEMED dropwise, and react at room temperature for 24 hours to obtain a gel product, soak and wash the obtained gel with deionized water to remove unreacted monomers.

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Abstract

The invention relates to multifunctional high-strength gel and a preparation method of the multifunctional high-strength gel. The multifunctional high-strength gel comprises the following steps: (1) preparing ionic liquids (ILs): selecting natural compound amino acid and choline, and preparing novel green ionic liquids through neutralization reaction; (2) modifying the ionic liquids (ILs): introducing double bonds into ILs through AAc under the effects of N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), thus obtaining a vinyl ionic liquid monomer with a polymerization function; (3) preparing the multifunctional high-strength gel: using functional monomers of temperature-responsive N-isopropylacrylamide (NIPAAm), pH-sensitive acrylic acid (AAc), conductive ionic liquid and the like to prepare the multifunctional high-strength gel in an ionic / covalent crosslinking system by a one-pot method. The method is simple and quick, conditions are mild, large equipment is not required, aqueous phase reaction is green and environment-friendly, and the method has a relatively high practical application value in the industry. The gel has good biocompatibility and biodegradability, and multifunctional responsiveness, and further has broad application prospects in fields of biological medicines, tissue engineering and the like.

Description

technical field [0001] The invention relates to the fields of biological materials, tissue engineering and polymer materials, in particular to a high-strength multifunctional gel and a preparation method thereof. Background technique [0002] Biomedical materials must adapt to the complex environment of organisms, so they need to have properties similar to natural materials in terms of biocompatibility and mechanical strength. Hydrogel has become an ideal substitute material because of its structure similar to human soft tissue, but its lack of mechanical strength has restricted its application for a long time. Taking articular cartilage as an example, it not only bears high pressure in human joints, but also absorbs impact energy from the outside world. However, once articular cartilage is damaged, it cannot be repaired with current medical technology. Therefore, to narrow the performance gap between polymer hydrogels and biological soft tissues, seek polymer hydrogel mate...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F220/54C08F220/60C08F222/38C08J3/075C08L51/02
CPCC08F251/00C08J3/075C08J2351/02C08F220/54
Inventor 贺晓凌梁芳叶富王甫邹良帅魏东盛
Owner TIANJIN POLYTECHNIC UNIV
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