Calcium alginate composite microsphere for stabilizing water-in-oil Pickering emulsion and preparation method thereof

A technology of Pickering emulsion and calcium alginate, which is applied in the field of calcium alginate composite microspheres and its preparation, can solve the problems of limited application, reduction of hydrophilicity, inability to stabilize water-in-oil Pickering emulsion, etc., and achieve Broad application prospects, strong practicability, and the effect of improving mechanical strength

Active Publication Date: 2017-05-17
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since calcium alginate microspheres are very hydrophilic, usually only oil-in-water Pickering emulsions can be stabilized; this limits the application of calcium alginate microspheres as emulsifiers for Pickering emulsion particles
In the prior art, the hydrophilicity of calcium alginate is reduced by coating with relatively hydrophobic chitosan, and calcium alginate

Method used

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  • Calcium alginate composite microsphere for stabilizing water-in-oil Pickering emulsion and preparation method thereof
  • Calcium alginate composite microsphere for stabilizing water-in-oil Pickering emulsion and preparation method thereof
  • Calcium alginate composite microsphere for stabilizing water-in-oil Pickering emulsion and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0047] (1) Alkylsilane-grafted TiO 2 Preparation of nanoparticles: (1) 1 g of commercially available TiO with a particle size of 25 nm 2 Nanoparticles were added to 15 mL of 30% by volume H 2 o 2 solution, ultrasonically dispersed for 5 min to obtain a dispersion; (2) sealed the dispersion and placed it in a dark place with magnetic stirring at 500 rpm for 2 h, unsealed and dried at 40 °C to obtain hydroxylated TiO 2 Nanoparticle powder; (3) The dried hydroxylated TiO 2 Nanoparticle powder was added to a mixture of 0.2 mL octaalkyltrichlorosilane and 19.8 mL n-hexane, ultrasonically dispersed for 5 min, and magnetically stirred at 500 rpm for 8 h, during which n-hexane was added to maintain the initial liquid level; (4) the previous The dispersion obtained in the step was centrifuged at 12000 rpm for 5 minutes at 4 °C, and the precipitate was dried at 40 °C to obtain the alkylsilane-grafted TiO 2 nanoparticles.

[0048] (2) Preparation of water-in-oil sodium alginate Pick...

Embodiment 2

[0053] (1) Alkylsilane-grafted SiO 2 Preparation of nanoparticles: (1) 1.8 g of commercially available SiO with a particle size of 25 nm 2 Nanoparticles were added to 15 mL of 30% by volume H 2 o 2 In the solution, ultrasonically disperse for 10 min to obtain a dispersion; (2) Seal the dispersion and place it in a dark place with magnetic stirring at 800 rpm for 6 h, unseal and dry at 60 °C to obtain hydroxylated SiO 2 nanoparticle powder; (3) the dried hydroxylated SiO 2 Nanoparticle powder was added to a mixture of 1 mL octaalkyltrichlorosilane and 19 mL n-hexane, ultrasonically dispersed for 10 min, and magnetically stirred at 800 rpm for 12 h, during which n-hexane was added to maintain the initial liquid level; (4) the previous The dispersion obtained in the step was centrifuged at 15000 rpm for 15 minutes at 4 °C, and the precipitate was dried at 60 °C to obtain the SiO grafted with alkylsilane. 2 nanoparticles.

[0054] (2) Preparation of water-in-oil sodium algina...

Embodiment 3

[0059] (1) Alkylsilane-grafted Fe 3 o 4 Preparation of nanoparticles: (1) 1.5 g of commercially available Fe with a particle size of 25 nm 3 o 4 Nanoparticles were added to 15 mL of 30% by volume H 2 o 2 solution, ultrasonically disperse for 8 min to obtain a dispersion; (2) seal the dispersion and place it in a dark place with magnetic stirring at 700 rpm for 4 h, unseal and dry at 50 °C to obtain hydroxylated Fe 3 o 4 Nanoparticle powder; (3) the hydroxylated modified Fe after drying 3 o 4Nanoparticle powder was added to a mixture of 0.5 mL octaalkyltrichlorosilane and 19.5 mL n-hexane, ultrasonically dispersed for 8 min, and magnetically stirred at 700 rpm for 10 h, during which n-hexane was added to maintain the initial liquid level; (4) the previous The dispersion obtained in the step was centrifuged at 13000 rpm for 10 min at 4 °C, and the precipitate was dried at 50 °C to obtain the alkylsilane-grafted Fe 3 o 4 nanoparticles.

[0060] (2) Preparation of water-...

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Abstract

The invention discloses a calcium alginate composite microsphere for stabilizing water-in-oil Pickering emulsion and a preparation method thereof, and belongs to the technical field of material high-molecular polymers. Alkylsilane grafted inorganic nanometer particles coat the surface of a calcium alginate microsphere to form the calcium alginate composite microsphere; the particle diameter distribution of the microsphere is 2 to 8 mum; the microsphere is of a core-shell structure; the core is hollow; the shell has two layers; the total thickness of the two layers of the shell is 1 to 1.5mum; the calcium alginate is an inner layer shell; the inorganic nanometer particle is assembled into the outermost layer shell; the technical defects that chitosan coats the surface of the calcium alginate microsphere, can only be used for stabilizing the water-in-oil Pickering emulsion, can only be used for encapsulating and sealing the oil-soluble medicine through being used as a medicine carrier, and cannot be used for encapsulating and sealing oil-soluble medicine are overcome; the calcium alginate composite microsphere is prepared by using an improved emulsion polymerization method; meanwhile, the characteristics of biocompatibility, adhesiveness, protein type macromolecule encapsulation and sealing and the like of the calcium alginate can be realized; the water-in-oil Pickering emulsion can be well stabilized; the calcium alginate composite microsphere can widely expand the application of Pickering emulsion as the medicine carrier to the fields of biologic medicine, cosmetics industry, food industry, enzyme engineering and the like.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a calcium alginate composite microsphere used for stabilizing water-in-oil Pickering emulsion and a preparation method thereof. Background technique [0002] Pickering emulsions are emulsions stabilized by solid particles, which are composed of water phase, oil phase and solid particles. Generally, hydrophilic solid particles can stabilize oil-in-water emulsions, and hydrophobic solid particles can stabilize water-in-oil emulsions. Compared with emulsions stabilized by traditional surfactants, Pickering emulsions have the advantages of high stability, low toxicity, and environmental friendliness, and have been widely used in drug delivery, cosmetics, and food industries. [0003] There are many solid particles used to stabilize Pickering emulsions, mainly divided into inorganic particles and organic particles. Considering limitations such as toxicity, biodegradabi...

Claims

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Application Information

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IPC IPC(8): C08J3/16C08J3/12C08L5/04B01J13/14A61K9/107A61K47/36A61K47/02A61K8/73A61K8/06A61K8/19A61K8/25A61K8/29A61Q19/00
CPCA61K8/06A61K8/19A61K8/25A61K8/29A61K8/73A61K9/107A61K47/02A61K47/36A61K2800/10A61Q19/00B01J13/14C08J3/12C08J3/16C08J2305/04
Inventor 孟涛杨鑫白瑞雪郭婷
Owner SOUTHWEST JIAOTONG UNIV
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