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Strontium carbonate-modified silk fibroin composite material and preparation method thereof

A composite material, strontium carbonate technology, applied in pharmaceutical formula, medical science, prosthesis, etc., can solve the problems of no biological activity, lack of characteristics, and practical application of strontium-doped biomaterials, so as to avoid thermal damage and improve mechanical properties , the effect of good biological characteristics

Inactive Publication Date: 2017-05-31
宁波芸生纺织品科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on silk fibroin as a bone repair material is still mainly inactive, and lacks the characteristics that rational bone tissue engineering scaffold materials such as bone growth induction and osteoconductivity should have.
[0003] Strontium and its compounds have an important role in osteogenesis. Therefore, strontium-doped biomaterials have become one of the research hotspots of bioactive bone repair materials, but the compatibility and interface effects of strontium and biomaterials are the key to the performance of composite materials. Unfortunately Unfortunately, there is no effective way to improve the compatibility of strontium with biomaterials in the prior art, which hinders the practical application of strontium-doped biomaterials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Synthetic example

[0025] Dissolve trimethylene carbonate, acrylate trimethylolethane cyclocarbonate in dichloromethane and stir for 15 minutes; then add trimethyl phosphite and bis(bistrimethylsilyl)amine zinc Dichloromethane solution, stirred for 35 minutes; then added propynyl alcohol, stirred for 30 minutes; followed by sealed reaction at 40 ° C for 40 hours, then terminated the reaction with glacial acetic acid, the reaction solution was precipitated in glacial ether, and the precipitate was vacuum-dried to obtain high Molecular material A; the mass ratio of trimethylene carbonate, acrylate trimethylolethane cyclocarbonate, trimethyl phosphite, bis(bistrimethylsilyl)amine zinc, and propynyl alcohol is 100: 80:20:0.1:5; polymer material A is dissolved in formic acid (pure) to prepare polymer material formic acid solution A with a concentration of 5 wt %;

[0026] Dissolve trimethylene carbonate, acrylate trimethylolethane cyclocarbonate in dichloromethane and stir for 8 minutes; then add tri...

Embodiment 1

[0029] (1) Boil mulberry silk with 0.5% sodium bicarbonate solution for 30 minutes to degumming, repeat 3 times to obtain silk fibroin fiber; dissolve silk fibroin fiber in strontium chloride formic acid solution (1wt%) to obtain silk fibroin solution (10wt%); add polymer material formic acid solution A; mix and dry to obtain strontium-containing regenerated silk fibroin film;

[0030] (2) In the presence of ammonium carbonate or ammonium bicarbonate, put the strontium-containing regenerated silk fibroin film into an airtight container for mineralization treatment to obtain a mineralized film; the mass ratio of strontium chloride, silk fibroin, and polymer materials (5~8):80:30; the temperature of mineralization treatment is 40-60°C, the time is 40-60 hours, and the relative humidity is 40-60%;

[0031] (3) Put the mineralized film in deionized water for 0.5-1 hour; then dry it to obtain the strontium carbonate modified silk fibroin composite material; the drying treatment is ...

Embodiment 2

[0034] (1) Boil mulberry silk with 0.5% sodium bicarbonate solution for 30 minutes to degumming, repeat 3 times to obtain silk fibroin fiber; dissolve silk fibroin fiber in strontium chloride formic acid solution (2wt%) to obtain silk fibroin solution (12wt%); add polymer material formic acid solution A; mix and dry to obtain strontium-containing regenerated silk fibroin film;

[0035](2) In the presence of ammonium carbonate or ammonium bicarbonate, put the strontium-containing regenerated silk fibroin film into an airtight container for mineralization treatment to obtain a mineralized film; the mass ratio of strontium chloride, silk fibroin, and polymer materials 7:80:30; the temperature of mineralization treatment is 40°C, the time is 60 hours, and the relative humidity is 40%;

[0036] (3) Put the mineralized film in deionized water for 1 hour; then dry it to obtain the strontium carbonate modified silk fibroin composite material; the drying treatment is placed at room tem...

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Abstract

The invention relates to a strontium carbonate-modified silk fibroin composite material and a preparation method thereof. The method comprises the steps of dissolving a high polymer material into formic acid to obtain a polymer material formic acid solution; degumming silk and then obtaining a silk fibroin fiber; dissolving the silk fibroin fiber into a strontium chloride formic acid solution to obtain a silk fibroin solution; adding the polymer material formic acid solution again; mixing and drying to obtain a strontium-containing regenerated fibroin membrane; putting the strontium-containing regenerated fibroin membrane into a close container for mineralization in the presence of ammonium carbonate or ammonium bicarbonate to obtain a mineralized membrane; putting the mineralized membrane into deionized water; and carrying out drying treatment to obtain the strontium carbonate-modified silk fibroin composite material. The breaking strength of the prepared composite material is 70-100MPa, the breaking elongation is 6-10%, the Young modulus is 3-5GPa and the composite material can be applied to preparation of a bone repair material.

Description

technical field [0001] The invention belongs to the technical field of biological composite materials, and in particular relates to a strontium carbonate modified silk fibroin composite material and a preparation method thereof. The prepared material has wide application prospects in the field of regenerative medicine. Background technique [0002] my country is the main producer of silk, and its silk output accounts for more than 70% of the world's output. Silk fibroin not only has good biocompatibility and degradation performance, but also is easy to process and modify, and the degradation products are non-toxic and low immunogenicity, as well as excellent physical and mechanical properties. Research extensively. Among them, the research of silk fibroin scaffold material in the field of bone tissue engineering has proved to be one of the hotspots. At present, silk fibroin has been successfully processed into various forms of bone tissue engineering scaffolds, including m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/54A61L27/58
CPCA61L27/446A61L27/54A61L27/58A61L2300/252A61L2300/412A61L2400/12A61L2430/02
Inventor 黄继伟张定
Owner 宁波芸生纺织品科技有限公司
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