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Traditional Chinese medicine patch for neck pain and preparation method thereof

A neck pain and patch technology, which is applied in the field of traditional Chinese medicine patch neck pain patch and its preparation field, can solve the problems of sweat retention, inability to apply for a long time, and natural rubber plaster is prone to allergies and the like.

Active Publication Date: 2020-09-08
北京乳凝创新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Natural rubber paste is prone to allergies, cannot be pasted repeatedly, loses viscosity when exposed to water, peels off pain, and is prone to problems such as "sweat retention" after long-term application
[0007] Hydrogel has poor paste performance, cannot be pasted for a long time, and there is also the problem that it cannot be pasted repeatedly

Method used

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  • Traditional Chinese medicine patch for neck pain and preparation method thereof
  • Traditional Chinese medicine patch for neck pain and preparation method thereof
  • Traditional Chinese medicine patch for neck pain and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] In this experiment, a traditional Chinese medicine transdermal patch was prepared by using styrene-isoprene-styrene block copolymer with 15% styrene content as the skeleton material, liquid paraffin as the softener, and hydrogenated rosin glyceride as the thickener Use drug carrier adhesives, as follows:

[0043]

[0044]Use styrene-isoprene-styrene block copolymer" as the skeleton material to prepare adhesives for medical transdermal patches, add tackifiers, softeners, antioxidants, and other special functional additives such as inorganic fillers , hydrophilic substances, etc. The specific additive raw materials are as follows:

[0045] Tackifier: The tackifier used in this embodiment can also be used in conjunction with one or more of the following, including: rosin resins, hydrogenated rosin resins, C5 petroleum resins, hydrogenated C5 petroleum resins, terpene Vinyl resins, C9 resins, C5-C9 resins, high molecular weight polyisobutylene, medium molecular weight p...

Embodiment 2

[0054] In this experiment, a combination of styrene-isoprene-styrene block copolymer and styrene-isoprene diblock copolymer with a styrene content of 15% was used as the skeleton material, and low molecular weight polyisobutylene with a molecular weight of 400 As a softener, hydrogenated rosin glyceride and polyisobutylene of different molecular weights were used as tackifiers to prepare drug carrier adhesives for neck pain patches, as follows:

[0055]

[0056] Using styrene-isoprene-styrene block copolymer and styrene-isoprene diblock copolymer as skeleton materials to prepare adhesives for medical transdermal patches, adding tackifiers, softeners, Antioxidants, inorganic fillers, other special functional additives, etc. The specific auxiliary raw materials are as described in Example 1.

[0057] The concrete preparation method of adhesive is as follows:

[0058] 1) Add styrene-isoprene-styrene block copolymer to the reactor, and start stirring at the same time;

[005...

Embodiment 3

[0063] In this experiment, a neck pain patch drug extract for the purpose of treating cervical spondylosis was prepared. The specific ingredients and preparation process are as follows:

[0064] The drug prescription for neck pain patch includes: Chuanxiong 330g, Qingfengteng 250g, Clematis 280g, Chishao 200g, Corydalis 120g, Sichuan pepper 250g, camphor 80g, menthol 35g, a total of 8 drugs.

[0065] Extraction preparation process: crush the above six herbs except camphor and menthol into coarse powder, moisten it with water, add 95% ethanol to soak for a certain period of time, percolate, and collect the percolate; continue to percolate with 75% ethanol , collect the percolate, combine the percolate, concentrate under reduced pressure to an extract with a relative density of 1.25-1.3, and set aside.

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Abstract

The present invention discloses a novel traditional Chinese medicine patch cervicodynia plaster and a preparation method thereof. The plaster mainly comprises drug compositions: ethanol solution extractives of ligusticum wallichii, caulis sinomenii, radix clematidis, root of common peony, corydalis tuber, and pericarpium zanthoxyli, as well as camphor and menthol; a drug carrying adhesive comprises compositions: a styrene-isoprene-styrene triblock copolymer, a styrene-isoprene diblock copolymer, a tackifier, a softener and an antioxygen; the plaster has the characteristics that stimulation to skins is free, allergy is avoided, the drug stabilization in long-term storage is good, the pasting with the skins is good, the repeatable pasting is realized, pasting is kept when contacted with water, and the like. The present invention also provides a novel process for preparing the novel traditional Chinese medicine patch cervicodynia plaster; the method has the characteristics that the drug heating time is short, only 10s-50s; the heating temperature is relatively low; heat sensitivity drug components can be effectively protected from running off due to oxygen damage caused by volatilization or heating; the effectiveness and the safety of drugs are effectively improved; and an organic solvent in the processing is not needed.

Description

technical field [0001] The invention relates to a drug transdermal patch for neck pain patch, a drug carrier adhesive and a preparation method of the drug transdermal patch, a drug transdermal patch for treating cervical spondylosis, and specific efficacy It can promote blood circulation, promote blood circulation and remove blood stasis, dispel cold and dehumidify, reduce swelling and relieve pain, and is used for cervical spondylosis (nerve root type) stagnation of blood stasis, cold-damp obstruction of collateral syndrome, symptoms include neck pain, shoulder and arm pain, poor neck movement, and limb pain. Numbness, aversion to cold, limb fatigue and other effects. Background technique [0002] Cervical spondylosis, also known as cervical syndrome, is a general term for cervical osteoarthritis, hypertrophic spondylitis, cervical nerve root syndrome, and cervical disc herniation. It is a disease based on degenerative pathological changes. Mainly due to long-term cervical...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/758A61K9/70A61K47/32A61P29/00A61P19/08A61K31/125A61K31/045
CPCA61K9/7053A61K31/045A61K31/125A61K36/236A61K36/59A61K36/65A61K36/66A61K36/71A61K36/716A61K36/758A61K2236/333A61K2236/51A61K2300/00
Inventor 侯玉庆刘彦宏陶几中马丹徐建梅侯天歌
Owner 北京乳凝创新生物科技有限公司