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Application of porous carbon nanorods in near-infrared light-induced dual phototherapy

A near-infrared light and nanorod technology, which is applied in the fields of advanced nanomaterials and biological and medical treatments, can solve the problems of inconsistent wavelength absorption, poor photobleaching resistance of organic photosensitizers, and easy photodegradation of active oxygen efficiency, etc. Single, overcome the poor ability to resist photobleaching, and achieve the effect of efficient minimally invasive synergistic treatment

Active Publication Date: 2020-06-16
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the dual phototherapy nanotherapeutic agents that have been studied are mainly divided into two categories: the first category is to use photothermal conversion nanomaterials such as gold nanorods, graphene, molybdenum disulfide nanosheets, etc. to load organic photosensitizers (Nano Research 2014, 7, 1291–1301; ACS Nano 2011, 5, 7000-7009; Nanoscale 2014, 6, 11219-11225); its disadvantages are that organic photosensitizers have poor photobleaching resistance, are prone to photodegradation for a long time and have low reactive oxygen generation efficiency, The wavelength absorption of organic photosensitizers and photothermal conversion nanomaterials is inconsistent, and lasers of different wavelengths are required to be irradiated alternately

Method used

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  • Application of porous carbon nanorods in near-infrared light-induced dual phototherapy
  • Application of porous carbon nanorods in near-infrared light-induced dual phototherapy
  • Application of porous carbon nanorods in near-infrared light-induced dual phototherapy

Examples

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Effect test

Embodiment 1

[0023] Dissolve trimesic acid and zinc acetate with a molar ratio of 1:1 respectively, mix with ultrasonic reaction, centrifuge, wash and dry to obtain zinc metal-organic framework material; calcinate at 800°C for 5 hours under nitrogen atmosphere and soak in hydrofluoric acid for 12 hours Metal oxides are removed to obtain porous carbon nanorods. Porous carbon nanorods were ultrasonically dispersed in PBS to prepare material solutions with gradient concentrations. Put the porous carbon nanorod solution under 808nm laser irradiation, the optical power density is 1.6W / cm 2 , the irradiation time was 20min, the interval was 1min, and the temperature change of the material solution was recorded; the ROS indicator DCFH-DA was added to detect the change of the ROS content in the solution.

Embodiment 2

[0025] Dissolve trimesic acid and zinc nitrate with a molar ratio of 1:1 respectively, mix and add triethylamine to react at room temperature, centrifuge, wash, and dry to obtain zinc metal-organic framework materials; calcinate at 800°C for 5 hours under nitrogen atmosphere and use hydrogen Soak in hydrofluoric acid for 12 hours to remove metal oxides to obtain porous carbon nanorods. Porous carbon nanorods were ultrasonically dispersed in PBS to prepare material solutions with gradient concentrations. Put the porous carbon nanorod solution under 808nm laser irradiation, the optical power density is 1.6W / cm 2 , the irradiation time was 20min, the interval was 1min, and the temperature change of the material solution was recorded; the ROS indicator DCFH-DA was added to detect the change of the ROS content in the solution.

Embodiment 3

[0027] Dissolve trimesic acid and zinc acetate with a molar ratio of 1:2 respectively, mix with ultrasonic reaction, centrifuge, wash, and dry to obtain a metal-organic framework material; calcinate at 800°C for 5 hours in a nitrogen atmosphere, and soak in hydrofluoric acid for 12 hours to remove metal oxides to obtain porous carbon nanorods. Porous carbon nanorods were ultrasonically dispersed in PBS to prepare material solutions with gradient concentrations. Put the porous carbon nanorod solution under 808nm laser irradiation, the optical power density is 0.8W / cm 2 , the irradiation time was 20min, the interval was 1min, and the temperature change of the material solution was recorded; ROS indicator DCFH-DA was added to detect the change of ROS content in the solution.

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Abstract

The application of porous carbon nanorods in near-infrared light-induced dual phototherapy. The feature of the present invention is to use porous carbon nanorods as a matrix to absorb near-infrared light energy, transform and generate high-energy heat and high-concentration active oxygen, so that it can be used as a phototherapy at the same time. Thermal and photodynamic therapeutic agents are used to kill tumor cells. Porous carbon nanorods have the characteristics of low production cost, good biological safety, strong infrared light absorption, high photothermal conversion rate, and high active oxygen production rate, which is conducive to improving the utilization rate of laser energy and enhancing the killing efficiency of cancer cells. Near-infrared light-induced dual phototherapy has broad application prospects.

Description

technical field [0001] The invention belongs to the field of advanced nanomaterials and biological and medical treatments, and specifically relates to the application of porous carbon nanorods in near-infrared light-induced dual phototherapy. Background technique [0002] Near-infrared light therapy technology (photodynamic therapy, photothermotherapy) uses near-infrared excitation as a light source to irradiate a photoconversion agent to generate a large amount of reactive oxygen species (ROS) and heat, so as to kill cancer cells with a high concentration of reactive oxygen species and high temperature. the goal of. Near-infrared light therapy technology has the advantages of large penetration depth, high selectivity, and small damage. It is a new technology for minimally invasive tumor treatment developed in recent years that has attracted much attention. [0003] Studies have found that the combination of photodynamic therapy and photothermal therapy, that is, dual photo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0052A61K41/0057
Inventor 吴仁安徐桂菊牛欢
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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