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Nano-liposome with microwave sensitivity-enhancing effect, and preparation method and application thereof

A technology of nano-liposome and microwave sensitization, which is applied in the field of biomedicine to achieve the effect of mild preparation conditions, good reproducibility and good development prospects

Inactive Publication Date: 2017-06-13
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of liposomes in the field of tumor microwave hyperthermia has not been reported yet.

Method used

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  • Nano-liposome with microwave sensitivity-enhancing effect, and preparation method and application thereof
  • Nano-liposome with microwave sensitivity-enhancing effect, and preparation method and application thereof
  • Nano-liposome with microwave sensitivity-enhancing effect, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0038] (1) Prepare 10wt% sodium chloride solution, and mix it evenly by ultrasonic vibration.

[0039] (2) According to the ratio of dipalmitoylphosphatidylcholine and cholesterol of 80-100:0-20, weigh the membrane material and dissolve it in an organic solvent, and then evaporate it in a rotary evaporator until the organic solvent is spin-dried, and then put it in a vacuum drying oven , dry overnight. Among them, the phospholipids are dipalmitoylphosphatidylcholine, phosphatidylglycerol, dilauroylphosphatidylcholine, dimyristoylphosphatidylcholine, lecithin, soybean lecithin, natural cephalin, synthetic cephalin, cardiolipin, Oleoylphosphatidylethanolamine, dioleoylphosphatidylcholine, dipalmitoylphosphatidic acid, dipalmitoylphosphatidic acid, dipalmitoylphosphatidylglycerol, distearoylphosphatidylglycerol, distearoylphosphatidylcholine one or more of

[0040] (3) Add pre-prepared sodium chloride solution as the core material, hydrate at constant temperature for 30 minutes...

specific Embodiment 2～10

[0050] With embodiment 1, its difference is only, the sodium chloride solution that adds uses Repone K, ferric chloride, ferrous chloride, magnesium chloride, calcium chloride, ammonium sulfate, ammonium chloride, ammonium carbonate and carbonic acid respectively One or more substitutions of ammonium hydrogen. The results were similar.

specific Embodiment 11～145

[0052] Same as Examples 1-10, the only difference is that the dipalmitoylphosphatidylcholine added in step (2) is respectively made of phosphatidylglycerol, dilauroylphosphatidylcholine, dimyristoylphosphatidylcholine, lecithin , soybean lecithin, natural cephalin, synthetic cephalin, cardiolipin, dioleoylphosphatidylethanolamine, dioleoylphosphatidylcholine, dipalmitoylphosphatidic acid, dipalmitoylphosphatidic acid, dipalmitoylphosphatidylglycerol, One or more of stearoylphosphatidylglycerol and distearoylphosphatidylcholine were used instead, and the results were similar.

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PUM

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Abstract

The invention discloses a nano-liposome with a microwave sensitivity-enhancing effect, and a preparation process thereof. The diameter of the nano-liposome is 30 to 1000 nanometers, and the lipid double-layer thickness of the nano-liposome is 4 to 6 nanometers. After the surface of the nano-liposome is connected with antibody molecules through electrostatic adsorption or chemical bond, the active target seeking function of the nano-liposome is enhanced, the nano-liposome is easily enriched at the tumor location, and damage to normal tissues is reduced in the treatment process. The nano-liposome is applied to the technical field of tumor microwave thermal therapy for the first time, the nano-liposome has a good microwave temperature-increasing effect, and the grain size is uniform and controllable. The nano-liposome is simple in process, high in production efficiency and easy in large-scale production. In addition, the liposome is applied to clinical practice, so that compared with other nanometer materials, the nano-liposome has more esurience on safety and has good clinical application potential.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically designs a nano liposome with microwave sensitization effect, a preparation method thereof and an application in microwave hyperthermia for tumors. Background technique [0002] Cancer has become one of the leading global causes of death threatening human health, and its incidence is increasing year by year. At present, the traditional treatment methods for cancer commonly used in medicine include surgical resection, chemotherapy, radiotherapy, etc., and these methods will bring certain pain and side effects to patients during the treatment process. [0003] Microwave ablation as an emerging cancer treatment has been gradually accepted in recent years. Microwave hyperthermia converts electromagnetic wave energy into thermal energy, and kills tumor cells through thermal ablation. It has many advantages such as simplicity and convenience, non-invasive or minimally invasiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/127A61P35/00
CPCA61K9/127A61K41/0052
Inventor 戴志飞靳玉慎张晓婷安云坤
Owner PEKING UNIV