Preparation method of magnetic nano ferric oxide

A magnetic nanometer and iron oxide technology, which is applied in the direction of iron oxide, iron oxide/iron hydroxide, etc., can solve the problems of poor magnetic properties of the crystal structure and limited biomedical applications, and achieve dense iron core crystals and good crystallinity Effect

Active Publication Date: 2017-06-13
SOUTHEAST UNIV
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  • Abstract
  • Description
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Problems solved by technology

Although these superparamagnetic iron oxide nanomedicines are highly biocompatible, their biomedical applications are often limited due to large defects in the crystal structure and poor magnetic properties.

Method used

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  • Preparation method of magnetic nano ferric oxide
  • Preparation method of magnetic nano ferric oxide
  • Preparation method of magnetic nano ferric oxide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 168mg of polydextrose sorbitol carboxymethyl ether was placed in a 5mL plastic cryovial, and 2.5mL of ultrapure water was added, sonicated to fully dissolve it. Add 92 mg of ferric chloride hexahydrate and 46 mg of ferrous chloride tetrahydrate into 1.5 mL of ultrapure water, and after fully dissolving, add the solution into the solution of polydextrose sorbitol carboxymethyl ether. Shake and mix well at room temperature, under nitrogen protection for 10 minutes. The reaction vessel is placed in high-frequency induction heating equipment (the high-frequency induction heating equipment model is SPG-06-I, or SPG-06-II, or SPG-06-III, or SPG-06-IV, purchased from In the center of the induction coil of Shenzhen Shuangping Power Technology Co., Ltd., industrial alcohol is used for external circulation, and the temperature of the solution is monitored by an optical fiber temperature probe to keep it at 0°C ± 0.4°C for 5 minutes. Turn on the high-frequency induction heating e...

Embodiment 2

[0023] 138mg of polydextrose sorbitol carboxymethyl ether was placed in a 5mL plastic cryovial, and 2mL of ultrapure water was added, sonicated to fully dissolve it. Add 100 mg of ferric chloride hexahydrate and 50 mg of ferrous chloride tetrahydrate into 1 mL of ultrapure water, and after fully dissolving, add the solution into the solution of polydextrose sorbitol carboxymethyl ether. Mix well at room temperature, under nitrogen protection for 10 minutes. The reaction vessel was placed in the center of the induction coil of the high-frequency induction heating equipment, and the external circulation was carried out by industrial alcohol to ensure a low temperature environment. The temperature of the solution was monitored by an optical fiber temperature measuring probe to keep it at 5°C ± 0.4°C for 5 minutes. Turn on the high-frequency induction heating equipment to generate an alternating magnetic field, adjust the output current to 25 amperes, and slowly add 0.5 mL of conc...

Embodiment 3

[0026] Example 3 Measurement of Hysteresis Loop and Saturation Magnetization of Products Prepared by Two Methods

[0027] The two samples were adjusted to a solution with a concentration of 10 mg / mL (calculated as iron), respectively added to the sample pool, placed in the built-in magnetic field of the vibrating sample magnetometer (Lakeshore 7407), and the equipment and test software were turned on. The hysteresis loop and saturation magnetization of the sample were obtained by self-detection, and the results are shown in the attached manual. image 3 shown.

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Abstract

The invention relates to a preparation method of magnetic nano ferric oxide, concretely comprising the step of synthesizing magnetic ferric oxide nanoparticles by adopting an alternating magnetic field solvent cold magnetic induced internal thermal mechanism. The preparation method is based on the traditional chemical co-precipitation principle, and the magnetic ferric oxide nanoparticles with a good crystal structure and good magnetic properties are obtained through internal thermal induction of an alternating magnetic field and external low temperature circulating cooling. Different from preparation of magnetic nanoparticles by adopting the traditional solvent thermal process, the preparation scheme utilizes the alternating magnetic field, and magnetic particles are synthesized through one solvent cold and slow nucleation growth process. Compared with the magnetic ferric oxide particles with the same size, saturation magnetization strength and relaxation rate of the product prepared by adopting the preparation method are improved by about twice, crystal defect is obviously reduced, and all the performance indexes of the product are also greatly improved.

Description

technical field [0001] The invention relates to a method for preparing magnetic nanometer iron oxide, in particular to the preparation of magnetic nanometer iron oxide by a water-cooled magnetically induced internal heat co-precipitation method induced by an alternating magnetic field. Background technique [0002] Magnetic nano-iron oxide is a nanomaterial widely used in the field of biomedicine, and plays an important role in magnetic resonance imaging in vivo and magnetic separation in vitro. At present, its preparation methods mainly include high-temperature pyrolysis method, hydrothermal method, sol-gel method and chemical co-precipitation method, etc., and these technologies have their own advantages and disadvantages. Both the high temperature pyrolysis method and the hydrothermal method adopt high temperature or high pressure conditions, and the obtained magnetic iron oxide nanoparticles have uniform morphology distribution and excellent magnetic properties, but are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/06
CPCC01G49/06C01P2004/04C01P2004/64C01P2006/42
Inventor 顾宁
Owner SOUTHEAST UNIV
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