Preparation method of bendroflumethiazide tablet

A Benfluflumethiazide tablet and Benfluflumethiazide technology, which is applied in the field of preparation of Benfluflumethiazide Tablets, can solve problems such as exceeding the standard, large substances, and content differences between Benfluflumethiazide tablets, and achieve high efficiency, Avoid high temperature problems, the effect of rapid drug dissolution

Inactive Publication Date: 2017-07-14
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The invention provides a bendroflumethiazide tablet and a preparation method thereof, which solves the problems of the existing bendfluthiazide tablet with relatively large content differences and related substances exceeding the standard

Method used

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  • Preparation method of bendroflumethiazide tablet
  • Preparation method of bendroflumethiazide tablet

Examples

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Effect test

Embodiment 1

[0026] The present embodiment provides a preparation method of bendroflumethiazide tablet, comprising the following steps:

[0027] (1) Add bendroflumethiazide and microcrystalline cellulose PH-102 with water and mix uniformly to obtain suspension 1;

[0028] (2) Suspension 1 is wet pulverized to obtain Suspension 2; said wet pulverization adopts the mode of colloid mill and high-speed stirring bead mill to carry out, and wet grinding adopts low-temperature water circulation cooling to reduce the temperature of grinding, circulating water The temperature is less than 15°C, and the particle size D90 of bendroflumethiazide after wet grinding is less than 30 μm;

[0029] (3) Add the suspension 2 into lactose and cornstarch by spraying, and use wet granulation;

[0030] (4) Dry the granules, pass through a 30-mesh sieve, add sodium starch glycolate and magnesium stearate, and compress into tablets. The batch size is 100,000 tablets, and the specification is 2.5 mg / tablet.

[003...

Embodiment 2

[0033] The present embodiment provides a preparation method of bendroflumethiazide tablet, comprising the following steps:

[0034] (1) Add bendroflumethiazide and microcrystalline cellulose PH-102 with water and mix uniformly to obtain suspension 1;

[0035] (2) Suspension 1 is wet pulverized to obtain Suspension 2; said wet pulverization adopts the mode of colloid mill and high-speed stirring bead mill to carry out, and wet grinding adopts low-temperature water circulation cooling to reduce the temperature of grinding, circulating water The temperature is less than 15°C, and the particle size D90 of bendroflumethiazide after wet grinding is less than 30 μm;

[0036] (3) Add the suspension 2 into lactose and cornstarch by spraying, and use wet granulation;

[0037] (4) Dry the granules, pass through a 30-mesh sieve, add sodium starch glycolate and magnesium stearate, and compress into tablets. The batch size is 100,000 tablets, and the specification is 2.5 mg / tablet.

[003...

Embodiment 3

[0040] The present embodiment provides a preparation method of bendroflumethiazide tablet, comprising the following steps:

[0041] (1) Add bendroflumethiazide and microcrystalline cellulose PH-102 with water and mix uniformly to obtain suspension 1;

[0042] (2) Suspension 1 is wet pulverized to obtain Suspension 2; said wet pulverization adopts the mode of colloid mill and high-speed stirring bead mill to carry out, and wet grinding adopts low-temperature water circulation cooling to reduce the temperature of grinding, circulating water The temperature is less than 15°C, and the particle size D90 of bendroflumethiazide after wet grinding is less than 30 μm;

[0043] (3) Add the suspension 2 into lactose and cornstarch by spraying, and use wet granulation;

[0044] (4) Dry the granules, pass through a 30-mesh sieve, add sodium starch glycolate and magnesium stearate, and compress into tablets. The batch size is 100,000 tablets, and the specification is 2.5 mg / tablet.

[004...

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Abstract

The invention discloses a preparation method of a bendroflumethiazide tablet and belongs to the technical field of medicine preparations. The preparation method comprises the steps of: adding water to bendroflumethiazide and microcrystalline cellulose PH-102 and uniformly mixing the components to obtain a first suspension liquid; performing wet-method pulverization to the first suspension liquid to obtain a second suspension liquid; spraying the second suspension liquid into lactose and corn starch and performing wet-method granulation; drying the granules, sieving the granules through a sieve in 30 meshes, adding carboxymethyl starch sodium and magnesium stearate, and tabletting the mixture to prepare the bendroflumethiazide tablet. The method effectively avoids a high temperature problem during a pulverization process in the prior art. The bendroflumethiazide tablet is homogeneous in content and is rapidly to dissolve out.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method of bendrofluthiazide tablets. Background technique [0002] Benzofluorothiazide is 3-benzyl-6-trifluoromethyl-7-sulfonylamino-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide thing. [0003] Efficacy and indications: 1. Edema diseases, excrete excess sodium and water in the body, reduce extracellular fluid volume, and eliminate edema. Common ones include congestive heart failure, cirrhotic ascites, nephrotic syndrome, acute and chronic nephritis edema, early chronic renal failure, sodium and water retention caused by adrenal corticosteroid and estrogen therapy. 2. High blood pressure. It can be used alone or in combination with other antihypertensive drugs. Mainly used for the treatment of essential hypertension. 3. Central or nephrogenic diabetes insipidus. 4. Nephrolithiasis. It is mainly used to prevent stones formed by calcium ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/26A61K31/549A61P7/10A61P9/12A61P7/12A61P13/12A61P13/04
CPCA61K9/2095A61K9/2018A61K9/2054A61K9/2059A61K31/549
Inventor 高煜操铖
Owner HUAYI PHARMA ANHUI CO LTD
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