Preparation method of bendroflumethiazide tablet
A Benfluflumethiazide tablet and Benfluflumethiazide technology, which is applied in the field of preparation of Benfluflumethiazide Tablets, can solve problems such as exceeding the standard, large substances, and content differences between Benfluflumethiazide tablets, and achieve high efficiency, Avoid high temperature problems, the effect of rapid drug dissolution
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Embodiment 1
[0026] The present embodiment provides a preparation method of bendroflumethiazide tablet, comprising the following steps:
[0027] (1) Add bendroflumethiazide and microcrystalline cellulose PH-102 with water and mix uniformly to obtain suspension 1;
[0028] (2) Suspension 1 is wet pulverized to obtain Suspension 2; said wet pulverization adopts the mode of colloid mill and high-speed stirring bead mill to carry out, and wet grinding adopts low-temperature water circulation cooling to reduce the temperature of grinding, circulating water The temperature is less than 15°C, and the particle size D90 of bendroflumethiazide after wet grinding is less than 30 μm;
[0029] (3) Add the suspension 2 into lactose and cornstarch by spraying, and use wet granulation;
[0030] (4) Dry the granules, pass through a 30-mesh sieve, add sodium starch glycolate and magnesium stearate, and compress into tablets. The batch size is 100,000 tablets, and the specification is 2.5 mg / tablet.
[003...
Embodiment 2
[0033] The present embodiment provides a preparation method of bendroflumethiazide tablet, comprising the following steps:
[0034] (1) Add bendroflumethiazide and microcrystalline cellulose PH-102 with water and mix uniformly to obtain suspension 1;
[0035] (2) Suspension 1 is wet pulverized to obtain Suspension 2; said wet pulverization adopts the mode of colloid mill and high-speed stirring bead mill to carry out, and wet grinding adopts low-temperature water circulation cooling to reduce the temperature of grinding, circulating water The temperature is less than 15°C, and the particle size D90 of bendroflumethiazide after wet grinding is less than 30 μm;
[0036] (3) Add the suspension 2 into lactose and cornstarch by spraying, and use wet granulation;
[0037] (4) Dry the granules, pass through a 30-mesh sieve, add sodium starch glycolate and magnesium stearate, and compress into tablets. The batch size is 100,000 tablets, and the specification is 2.5 mg / tablet.
[003...
Embodiment 3
[0040] The present embodiment provides a preparation method of bendroflumethiazide tablet, comprising the following steps:
[0041] (1) Add bendroflumethiazide and microcrystalline cellulose PH-102 with water and mix uniformly to obtain suspension 1;
[0042] (2) Suspension 1 is wet pulverized to obtain Suspension 2; said wet pulverization adopts the mode of colloid mill and high-speed stirring bead mill to carry out, and wet grinding adopts low-temperature water circulation cooling to reduce the temperature of grinding, circulating water The temperature is less than 15°C, and the particle size D90 of bendroflumethiazide after wet grinding is less than 30 μm;
[0043] (3) Add the suspension 2 into lactose and cornstarch by spraying, and use wet granulation;
[0044] (4) Dry the granules, pass through a 30-mesh sieve, add sodium starch glycolate and magnesium stearate, and compress into tablets. The batch size is 100,000 tablets, and the specification is 2.5 mg / tablet.
[004...
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