High-biocompatibility fiber

A biocompatible, fiber technology, applied in the field of highly biocompatible fibers, can solve the problems of poor biocompatibility, surgical failure, fibrous hyperplasia and adhesion, etc.

Active Publication Date: 2017-07-14
北京华钽生物科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (4) Due to trauma, excessive force, etc., tendon rupture and contraction are often caused. Clinically, polymer fibers are often used to repair tendons. Because of rejection, local fiber hyperplasia and adhesion are caused, resulting in surgical failure.
In the prior art, artificial synthetic membranes made of different materials are also used as artificial skin, but there is a problem of poor biocompatibility

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Fabrication of Highly Biocompatible Fibers

[0062] (1) The fiber substrate was ultrasonically cleaned in distilled water and absolute ethanol for 10 minutes to remove oil and dust on the surface of the substrate, and then dried with nitrogen.

[0063] (2) place the dried fiber base material in a vacuum chamber, and evacuate so that the vacuum degree of the vacuum chamber reaches 3×10 -4 Pa, argon gas is introduced, and the partial pressure of argon gas is 0.5Pa.

[0064] Turn on the power, apply a power of 100w, generate plasma, and sputter the surface of the fiber substrate for 10 minutes to remove oxides on the surface of the substrate, thereby increasing the adhesion between the substrate and the coating. Heat the vacuum chamber to 400°C, and then pass the reaction gas TiCl into the vacuum chamber 4 , the air pressure is 1.0Pa, the coating time is 10 minutes, and it is released after cooling.

[0065] (3) Place the titanium-plated fiber substrate in a physical va...

Embodiment 2

[0067] Manufacture of nerve guides

[0068] (1) The nerve guide was ultrasonically cleaned in distilled water and absolute ethanol for 10 minutes to remove oil and dust on the surface of the nerve guide, and then blown dry with nitrogen.

[0069] (2) Place the dried nerve guide into a vacuum chamber, and evacuate so that the vacuum degree of the vacuum chamber reaches 5×10 -4 Pa, argon gas is introduced, and the partial pressure of argon gas is 0.8Pa.

[0070] Turn on the power supply, apply a power of 100w, generate plasma, and sputter the surface of the nerve guide for 10 minutes to remove oxides on the surface of the nerve guide, thereby increasing the adhesion between the nerve guide and the coating. Heat the vacuum chamber to 400°C, and then pass the reaction gas TiCl into the vacuum chamber 4 , the air pressure is 1.2Pa, the coating time is 15 minutes, and it is released after cooling.

[0071] (3) Place the titanium-plated nerve guide in the physical vapor deposition...

Embodiment 3

[0073] Manufacturing Surgical Meshes

[0074] (1) The fiber-woven surgical patch was ultrasonically cleaned in distilled water and absolute ethanol for 10 minutes to remove oil and dust on the surface of the surgical patch, and then dried.

[0075] (2) Place the dried surgical patch in a vacuum chamber and evacuate to make the vacuum of the vacuum chamber reach 6×10 -4 Pa, argon gas is introduced, and the partial pressure of argon gas is 1.0Pa.

[0076] Turn on the power, apply a power of 100w, generate plasma, and sputter the surface of the surgical patch for 10 minutes to remove oxides on the surface of the surgical patch, thereby increasing the adhesion between the surgical patch and the coating. Heat the vacuum chamber to 400°C, and then pass the reaction gas TiCl into the vacuum chamber 4 , the air pressure is 1.0Pa, the coating time is 10 minutes, and it is released after cooling.

[0077] (3) The titanium-plated surgical patch was placed in a physical vapor depositio...

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Abstract

The invention provides a high-biocompatibility fiber including a fiber base material and a plating layer. The plating layer includes a titanium plating layer formed on the fiber base material and a tantalum-containing plating layer formed on the titanium plating layer. The tantalum-containing plating layer may also include silver, zinc, strontium or like. The titanium plating layer is formed by plating titanium on the fiber base material through a plasma chemical vapor deposition method. The tantalum-containing plating layer is formed by plating a tantalum-containing material on the titanium film layer through a physical vapor deposition method. The high-biocompatibility fiber has antibacterial, healing promoting and tissue growth inducing functions.

Description

technical field [0001] The invention relates to a high biocompatibility fiber, in particular to a high biocompatibility fiber manufactured by chemical and physical vapor deposition technology. Background technique [0002] In recent years, synthetic fibers have been used more and more widely in the medical field, especially in the manufacture of artificial organs. The polymer materials have certain mechanical strength, chemical stability, softness, and easy processing and molding. Advantages, widely used in the field of artificial organ manufacturing. [0003] In the medical field, synthetic fibers can be used as nerve guides, surgical patches, artificial blood vessels and sutures, artificial tendons, artificial skin, burn wound dressings, etc. Fiber materials used in the human body need to have good biocompatibility and biocompatibility, but the existing medical devices made of fiber products have the following shortcomings: [0004] (1) The use of nerve conduits to bridg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/50A61L27/54A61L27/60A61L31/08A61L31/14A61L31/16C23C28/02C23C16/50C23C16/14C23C14/35C23C14/16C23C14/06
CPCA61L27/306A61L27/50A61L27/507A61L27/54A61L27/60A61L31/088A61L31/14A61L31/16A61L2300/102A61L2300/104A61L2300/404A61L2300/412A61L2400/18A61L2420/02A61L2420/06A61L2420/08A61L2430/32C23C14/0688C23C14/165C23C14/35C23C16/14C23C16/50C23C28/021C23C28/027
Inventor 姜培齐陈亮王健宋国安陶亚威周一行
Owner 北京华钽生物科技开发有限公司
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