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Preparation method of graphene oxide/nanosilver coating wrapped by collagen film

A technology of collagen film and collagen, which is applied in the field of preparation of graphene oxide/nano-silver coating wrapped in collagen film, can solve the problems of fast degradation speed and low mechanical properties of collagen, and achieve low investment in equipment and good quality. Photodynamic antibacterial activity, effect with little implementation difficulty

Active Publication Date: 2017-08-04
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, collagen has low mechanical properties and degrades rapidly

Method used

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  • Preparation method of graphene oxide/nanosilver coating wrapped by collagen film
  • Preparation method of graphene oxide/nanosilver coating wrapped by collagen film
  • Preparation method of graphene oxide/nanosilver coating wrapped by collagen film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Ultrasonic disperse the graphene oxide into a 1 mg / ml solution, take 50 ml and add 0.0679 g of silver nitrate, stir for 30 minutes, and place it under vacuum for 2 days in the dark. Finally, under the condition of continuous stirring, the solution was irradiated with 275 nm ultraviolet light for 1 hour, and the solution was set aside.

[0043] (2) Grind the medical titanium sheet to a smooth mirror surface on a polishing grinder with 240#, 400#, 600#, 800#, 1200# sandpaper, and then use 1:3 H 2 o 2 :H 2 SO4 The (concentrated) mixed solution was chemically etched for 30 minutes.

[0044] (3) Then put it into a reaction kettle filled with 4mol / L KOH solution, put the reaction kettle into an oven, react at 80°C for 90 minutes, and finally take it out for washing and drying.

[0045] (4) Immerse the treated titanium sheet in 3% silane coupling agent toluene solution, reflux at 80° C. for 12 hours, take it out, wash and dry with ethanol. Then immerse in the graphene ...

Embodiment 2

[0049] (1) Prepare graphene oxide / silver nitrate solutions with concentrations of 1.2mg / L and 0.01mol / L respectively, place the prepared graphene oxide / silver nitrate solution in vacuum for 1 day, and then irradiate with ultraviolet light under continuous stirring Reduction to obtain a graphene oxide composite material uniformly loaded with nano-silver;

[0050] (2) After polishing the surface of a titanium metal disc with a diameter of 6 mm and a thickness of 2.5 mm with sandpaper, it was cleaned in acetone, distilled water, and alcohol in sequence, and then cleaned with 1:3 H 2 o 2 :H 2 SO 4 (concentrated) mixed solution chemical etching for 30 minutes

[0051] (3) Put the above-mentioned titanium sheet into a reaction kettle filled with a KOH solution with a concentration of 4mol / L, put the reaction kettle into an oven, react at 85°C for 80 minutes, take it out, wash and dry;

[0052] (4) Immerse the treated titanium sheet in 5% toluene solution of silane coupling agent...

Embodiment 3

[0055] (1) Prepare graphene oxide / silver nitrate solutions with concentrations of 1mg / L and 0.008mol / L respectively, place the prepared graphene oxide / silver nitrate solutions in vacuum for 2 days, and then irradiate and reduce them with ultraviolet light under continuous stirring A graphene oxide composite material uniformly loaded with nano-silver was obtained.

[0056] (2) Grind the titanium sheet with sandpaper of specifications 240#, 400#, 600#, 800#, and 1200# on a polishing grinder to a smooth mirror surface, and then use 1:4:5 HF:1mol / LHNO 3 :H 2 The mixed solution of O was chemically etched for 2 minutes, then put it into a reaction kettle filled with a KOH solution with a concentration of 4mol / L, put the reaction kettle in an oven, reacted at 80°C for 90 minutes, took it out, washed and dried;

[0057] (3) The titanium sheet after the above treatment was immersed in a Tris-HCl (pH=8.5) buffer solution containing 2 mg / mL dopamine hydrochloride in the dark, left for 2...

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Abstract

The invention discloses a preparation method of a graphene oxide / nanosilver coating wrapped by collagen film. The preparation method includes steps: loading nanosilver on the surface of graphene oxide; subjecting a titanium sheet to alkali-heat treatment; aminating the titanium sheet; loading a graphene oxide / nanosilver composite material on the surface of the titanium sheet; covering the surface of the titanium sheet with the collagen film after compositing is finished. Graphene oxide, nanosilver and collagen are organically combined, nanosilver is uniformly loaded on a graphene oxide sheet in a size of several nanometers through graphene oxide, and the defect that collagen is prone to degradation is improved. A hybrid coating material prepared by the method has antibacterial activity and high biocompatibility, and the hybrid coating is irradiated by visible light to generate active oxygen to kill bacteria.

Description

technical field [0001] The invention relates to the technical fields of material science and nanomaterials, in particular to a method for preparing a graphene oxide / nano-silver coating wrapped in a collagen film. Background technique [0002] Biomedical materials are materials that are used to diagnose, treat, repair, or replace diseased tissues and organs of living organisms or enhance their functions, and will not have adverse effects on biological tissues. It is the basis for the study of artificial organs and medical devices, and has become an important branch of contemporary material science. Medical titanium has excellent corrosion resistance, elastic modulus close to that of natural bone, and excellent biocompatibility. It is currently commonly used in the manufacture of medical devices, prostheses or artificial organs and auxiliary treatment equipment implanted in the human body. [0003] However, the bacterial infection caused by medical implants has brought great ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/34A61L27/30A61L27/54A61L27/50A61L31/02A61L31/10A61L31/08A61L31/14A61L31/16B22F9/24B22F9/30
CPCA61L27/06A61L27/303A61L27/34A61L27/50A61L27/54A61L31/022A61L31/084A61L31/10A61L31/14A61L31/16A61L2300/104A61L2300/404A61L2300/606B22F9/24B22F9/30C08L89/00
Inventor 吴水林谢显洲刘想梅崔振铎杨贤金
Owner HUBEI UNIV
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