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A preparation method of multifunctional biological coating on the surface of medical titanium alloy

A bio-coating and titanium alloy technology, applied in the field of membrane materials, can solve problems such as affecting the performance of implantable medical devices and threatening the health of patients, and achieve the effects of cheap raw materials, simple and easy methods, and good practicability

Active Publication Date: 2019-04-12
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Another key issue affecting the performance of implantable medical devices is that nosocomial infections caused by bacteria growing on the surface of implantable medical devices seriously threaten the health of patients

Method used

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  • A preparation method of multifunctional biological coating on the surface of medical titanium alloy
  • A preparation method of multifunctional biological coating on the surface of medical titanium alloy
  • A preparation method of multifunctional biological coating on the surface of medical titanium alloy

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preparation example Construction

[0028] A method for preparing a multifunctional biological coating on the surface of a medical titanium alloy, comprising the steps of:

[0029] 1) Micro-arc oxidation surface treatment: Micro-arc oxidation technology is used to form a porous oxide coating on the surface to increase the surface area of ​​the material; the titanium alloy is subjected to surface micro-arc oxidation treatment under the power mode of bidirectional pulse constant voltage mode. Its surface is prepared with a phosphorus oxide coating; the electrolyte used in the micro-arc oxidation process mainly includes water and phosphate; the concentration of phosphoric acid is 0.01-0.05mol / L;

[0030] In the process of micro-arc oxidation surface treatment method, the composition of micro-arc oxidation electrolyte is phosphoric acid, sodium phosphate, potassium phosphate, sodium metaphosphate, etc.; In 10-30 minutes, the forward voltage is 200-500V, the negative voltage is 60-100V, the frequency is 400-1000HZ, a...

Embodiment 1

[0039] 1) Preparation of titanium alloy materials: After Ti6Al4V rods are wire-cut and polished, they are ultrasonically cleaned with water, ethanol and acetone, respectively, for 15 minutes each time;

[0040] 2) Micro-arc oxidation treatment of titanium alloy surface: the electrolyte used is phosphoric acid solution with a concentration of 0.01mol / L, the temperature of the electrolyte is 25°C, the power supply mode is bidirectional pulse constant voltage mode, the oxidation time is 10min, and the forward voltage is 200V , the negative voltage is 60V, the frequency is 400HZ, and the duty cycle is 15%;

[0041] 3) Phytic acid surface treatment: the surface is treated with phytic acid to form a coating with phytic acid on the surface. The phytic acid surface modification treatment process is as follows: diluting the phytic acid aqueous solution with a mass fraction of 50% concentration, putting the titanium alloy after the micro-arc oxidation treatment into a beaker with a mass f...

Embodiment 2

[0043] 1) Preparation of titanium alloy materials: After Ti6Al4V rods are wire-cut and polished, they are ultrasonically cleaned with water, ethanol and acetone, respectively, for 15 minutes each time;

[0044] 2) Micro-arc oxidation treatment of titanium alloy surface: the electrolyte used is phosphoric acid solution with a concentration of 0.04mol / L, the temperature of the electrolyte is 40°C, the power supply mode is bidirectional pulse constant voltage mode, the oxidation time is 30min, and the forward voltage is 450V , the negative voltage is 90V, the frequency is 800HZ, and the duty cycle is 40%;

[0045] 3) Phytic acid surface treatment: the surface is treated with phytic acid to form a coating with phytic acid on the surface. The phytic acid surface modification treatment process is as follows: dilute the phytic acid aqueous solution with a mass fraction of 50% concentration, put the titanium alloy after micro-arc oxidation treatment into a beaker with a concentration ...

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Abstract

The invention discloses a method for preparing a medical titanium alloy surface multifunctional biological coating, and belongs to the technical field of film materials. The method comprises the following steps that 1), micro-arc oxidation surface treatment is carried out, wherein a titanium alloy is subjected to surface micro-arc oxidation treatment when the power source mode is a bidirectional pulse constant-voltage mode, adopted electrolyte comprises water and phosphate, and the titanium alloy subjected to micro-arc oxidation treatment is obtained; 2), phytic acid decoration surface treatment is carried out, wherein the titanium alloy subjected to micro-arc oxidation treatment is placed in a flask containing a diluted phytic acid solution, and the flask is placed on a constant-temperature shaking table for room temperature vibrating reacting; and 3), polyvalent cations are cross-linked with a phytic acid coating, wherein after the titanium alloy subjected to phytic acid decoration surface treatment is soaked, a water solution including polyvalent cation salt is added, and a polyvalent cation cross-linked phytic acid coating is obtained after vibration. The bacterium resistance of the surface of a titanium alloy material can be remarkably improved, the blood compatibility and corrosion resistance of the surface of the material are considered at the same time, raw materials are cheap, the method is simple and easy to implement, and the process cost is low.

Description

technical field [0001] The invention belongs to the technical field of membrane materials, and in particular relates to a method for preparing a multifunctional biological coating on the surface of a medical titanium alloy. Background technique [0002] According to the 2012 statistics on the cause of death of urban residents in the "China Health Statistical Yearbook Data", the three major causes of death that threaten residents' health are malignant tumors, heart disease and cerebrovascular disease, accounting for 26.81%, 21.45% and 19.61% respectively. Since the 1980s, cardiovascular and cerebrovascular diseases have been a serious threat to human health. In order to cope with the diagnosis, prevention and treatment of cardiovascular and cerebrovascular diseases, cardiovascular and cerebrovascular devices and devices have also developed rapidly. There are many kinds of blood-contacting materials. Gao Changyou et al. classified blood-contacting materials for cardiovascular ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C25D11/26A61L31/08A61L31/02A61L31/16
CPCA61L31/022A61L31/08A61L31/16A61L2300/21A61L2300/404A61L2300/606C25D11/26
Inventor 叶玮任永祝刘爱辉林岳宾陈新建丁红燕
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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