Synthesis method of trifluoropyruvate compounds

Abstract

The invention discloses a synthesis method of trifluoropyruvate compounds. The method comprises the following steps: carrying out exchange reaction on an activator and a metal oxide under heating conditions to form a novel solid acid catalyst; and carrying out gas-phase catalytic reaction on the raw material 2-fluoro-2-alkoxy-trifluoropropionate under the action of the novel solid acid catalyst under high-temperature conditions to prepare the trifluoropyruvate compounds by one step. In the synthesis method of trifluoropyruvate compounds, the novel solid acid catalyst is prepared; and the novel solid acid catalyst can be effectively used for catalyzing the synthesis of trifluoropyruvates. The catalyst is used for catalyzing the synthesis of the trifluoropyruvate compound products for the first time in the invention. The method has the advantages of simple process route, short reaction time, higher reaction yield, fewer byproducts and recyclable catalyst, and thus, is suitable for expanded production and worthy of popularization.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a method for synthesizing trifluoropyruvate compounds. Background technique [0002] Trifluoropyruvate compounds are currently the most demanded trifluoromethylation reagents and play an important role in the synthesis of organic fluorine chemicals. This type of compound has two reaction centers, namely a carbonyl group and an ester group, making it possible to synthesize trifluoromethyl heterocyclic compounds. This kind of compound has been widely used as the most precursor raw material of a new generation of medicine and pesticide. For example, in the pharmaceutical industry, trifluoropyruvate compounds can be used to synthesize anti-inflammatory drugs, anti-cancer and anti-viral drugs. [0003] The synthetic routes of trifluoropyruvate compounds are mainly as follows: [0004] One is to use bromotrifluoromethane and oxalic acid diester as raw materials, under nor...

AI Technical Summary

Problems solved by technology

This route has the problem of waste acid polluting the environment, many by-products, difficult separation, process stability and product quality are difficult to guarantee in industrial production; another kind of route is strong Lewis acid catalyzed synthesis route, in this process route, Strong Lewis acids such as antimony pentafluoride, etc., can not only catalyze the reaction raw material 2-fluoro-2-alkoxy-trifluoropropionate in liquid phase, but also support antimony pentafluoride on other substrates such as graphite, etc. , the reaction raw material 2-fluoro-2-alkoxy-trifluoropropionate is catalyzed in the gas phase, and trifluoropyruvate can be obtained

However, this type of catalyst is expensive, and a large amount of hydrogen fluoride will be produced during the reaction process, which requires high equipment. The antimony pentafluoride after failure is not easy to handle, and the reaction conditions are not easy to control, which may cause excessive reaction and further react with trifluoropyruvate to form Trifluoropropionate; Another route is a solid acid gas-phase catalytic synthesis route, that is, 2-fluoro-2-alkoxy-trifluoropropionate and a class of solid acid (aluminum oxide, titanium oxide and zirconium oxide, etc. Loaded nickel sulfate and iron sulfate) are the main raw materials, and react under heating conditions to obtain trifluoropyruvate

The reaction time of this route is long, the yield is low, and the preparation process of solid acid catalyst is complex

Based on the above statement, it can be seen that the existing synthetic methods of trifluoropyruvate compounds have complicated process, long reaction time, many by-products, large amount of three wastes, expensive catalysts, and are not suitable for large-scale production.

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