Mesoporous material and application of mesoporous material as medicine carrier

Abstract

The invention discloses a mesoporous material and application of the mesoporous material as a medicine carrier. The mesoporous material comprises mesoporous silica nanoparticles and are prepared from hexadecyl trimethyl ammonium bromide as a template agent and an organic solvent solution as a solvent system by enabling a silicon source to react under catalysis of alkali; the template agent further comprises isothiazolinone and is a compounded template agent comprising hexadecyl trimethyl ammonium bromide and isothiazolinone in a mass ratio of (4-6):1; the organic solvent solution is an aqueous solution of dimethyl sulfoxide; the volume concentration percentage of the dimethyl sulfoxide is 18-22%. The mesoporous silica nanoparticles disclosed by the invention are high in medicine carrying capacity, the medicine carrying capacity can be increased, the use amount can be reduced when a medicine is prepared from the mesoporous material as a carrier, and thus the taking burden of patients is alleviated; by taking gemcitabine as an example, the carrying capacity of the mesoporous silica nanoparticles for gemcitabine is about 60%, and thus the carrying capacity is remarkably prior to that of the prior art.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a mesoporous material and its use as a drug carrier. Background technique [0002] Mesoporous silica materials are increasingly used in drug delivery due to their structural stability. Mesoporous silica has the advantages of controllable particle size, easy phagocytosis by cells, good biocompatibility, easy surface functionalization, large particle surface area and pore capacity, large drug loading capacity, and low selectivity to drugs. The method is simple and is expected to become an ideal drug carrier. [0003] There are four main raw materials in the synthesis of mesoporous silica: inorganic silicon sources, generally inorganic substances such as sodium silicate or organic substances such as tetraethyl orthosilicate; surfactants, as template substances, mainly cationic (long chain Alkyl quaternary ammonium salts, etc.), anionic, nonionic (block copolymers, l...

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Problems solved by technology

[0005] The low drug loading directly leads to the need to give a larger dose of the total drug when the patient is treated with the same dose of active ingredients of the drug (the proportion of the mesoporous silica carrier is too high), which increases the patient's drug use to a certain extent. burden

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