Near-infrared nanoprobe, preparation method and holographic molecular imaging navigation system

Abstract

The invention discloses a near-infrared nanoprobe, a preparation method and a holographic molecular imaging navigation system. The preparation method of the near-infrared nanoprobe comprises the steps that a mixed solution of near-infrared fluorescent dyes is obtained; iodinated oil injection is added into the mixed solution; an organic solvent in the mixed solution where the iodinated oil injection is added is volatilized, and an iodinated oil mixed solution is obtained; a nano surface active agent is dissolved into absolute ethyl alcohol, and a nano surface active agent solution is obtained; the nano surface active agent solution and the iodinated oil mixed solution are added into a polyethylene glycol solution, and a nano preparation is formed; and the nano preparation is filtered, and the near-infrared nanoprobe is obtained. The physical and chemical properties of the near-infrared nanoprobe are more stable, and an excellent fluorescence enhancing effect and biological stability are achieved; and meanwhile the assorted holographic molecular imaging navigation system is combined, a cancer area can be clearly recognized, and the liver cancer boundary is determined, so that precise excision of a cancer lesion is achieved.

Description

technical field [0001] The disclosure belongs to the technical field of nano-medicine and medical engineering, and relates to a near-infrared nano-probe, a preparation method and a holographic molecular image navigation system. Background technique [0002] Liver cancer is one of the most common tumors in my country, with a high mortality rate. In the treatment of liver cancer, surgery is the treatment of choice. However, in liver cancer resection, there are major clinical problems such as difficult to accurately identify tumor boundaries and difficult to effectively detect tumor thrombi. With the continuous development of molecular imaging technology, surgery using near-infrared fluorescence equipment for navigation has become possible. [0003] Liver cancer surgery under the guidance of molecular image navigation system requires near-infrared probes with high biosafety, high stability and high fluorescence quantum yield. Fluorescence dyeing indocyanine green (ICG), new ...

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Problems solved by technology

Fluorescence dyeing indocyanine green (ICG), new indocyanine green IR-820 and cyanine dyes have strong absorption and emission characteristics at around 800nm, and have good biological safety, and ICG is widely used It is a kind of near-infrared dye, and it is clinically used in the test of liver function, so the operation of navigating with near-infrared fluorescence equipment has application value, but fluorescent molecules such as ICG have the disadvantages of easy decomposition and short duration in vivo, and will After ICG is injected into the hepatic artery, the existing matching molecular imaging navigation system cannot clearly distinguish the cancer area and the boundary between it and normal tissue

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