Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Temperature sensitive-type hydrogel nano drug delivery system

A temperature-sensitive, hydrogel nano-technology, applied in the field of medicine, to achieve the effect of improving the therapeutic effect, improving the curative effect, and uniform particle size

Active Publication Date: 2017-11-24
CHONGQING UNIV
View PDF2 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the fact that is easily overlooked by people is that there are various barriers in the human body (lymphatic system, lysozyme, interferon, phagocytes, etc.), and it is difficult for many chemotherapy drugs to break through these barriers and reach the vicinity of the tumor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Temperature sensitive-type hydrogel nano drug delivery system
  • Temperature sensitive-type hydrogel nano drug delivery system
  • Temperature sensitive-type hydrogel nano drug delivery system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 100 parts of N-isopropylacrylamide (NIPAM), 35 parts of acrylic acid (AA), 5 parts of N,N-methylenebisacrylamide, 1 part of sodium dodecylsulfonate, ammonium persulfate / sulfurous acid Mix 10 parts of sodium hydrogen, 60 parts of water, 10 parts of receptor tyrosine kinase inhibitor, 10 parts of anti-angiogenic agent, and 10 parts of propanol, and remove the air in the reaction system at 0-50°C for 0.1-2 hours , under anaerobic conditions, heating the reaction system to 35-100°C for 4-20 hours to obtain the product;

[0045] 3) Obtain the centrifuged product by washing and centrifuging for many times;

[0046] 4) Vacuum drying the product obtained in step 3) at 0-50° C. to obtain a hydrogel nano drug delivery system.

[0047] Detection:

[0048] The polymerization reaction of temperature-sensitive nanohydrogels was verified by infrared spectrophotometer. From the infrared spectrum analysis chart (see figure 1 ), it can be seen that the curve NIPAM / AA is a mixture of ...

Embodiment 2

[0053] 100 parts of N-isopropylacrylamide (NIPAM), acrylic acid (AA) (the molar ratios of N-isopropylacrylamide and acrylic acid are 98:2 / 95:5 / 92:8 / 90:10), 5 parts of N,N-methylenebisacrylamide, 1 part of sodium dodecylsulfonate, 0.1 part of potassium persulfate, 50 parts of water, 10 parts of PI3K / mTOR / AKT inhibitor, 10 parts of isopropanol and mix well , remove the air in the reaction system at 0-50°C for 0.1-2 hours, and heat the reaction system to 35-100°C for 4-20 hours under anaerobic conditions to obtain the product;

[0054] 3) Obtain the centrifuged product by washing and centrifuging for many times;

[0055] 4) Vacuum drying the product obtained in step 3) at 0-50° C. to obtain a hydrogel nano drug delivery system.

[0056] Detection:

[0057] The particle diameters of the nano-drug delivery system obtained in this example were measured by a laser particle size analyzer to be 100-300 nm.

[0058] Optimization of temperature-sensitive nano-hydrogels: The light tran...

Embodiment 3

[0060] 100 parts of N-isopropylacrylamide, 15 parts of acrylic acid, 20 parts of N,N-methylenebisacrylamide, 3 parts of sodium dodecylsulfonate, 15 parts of ammonium persulfate initiator, 50 parts of water, After mixing 5 parts of monoclonal antibody anticancer drugs and 100 parts of glucose, the air in the liquid was removed at 25°C for 0.1 hour, and the reaction system was heated to 60°C for 8 hours under anaerobic conditions to obtain the product. The unwrapped drug or anticancer drug inclusions and auxiliary agents and unpolymerized small molecule raw materials were removed by dialysis separation, and the hydrogel nano drug delivery system was obtained by vacuum drying at 25°C.

[0061] Detection:

[0062] The particle diameters of the nano-drug delivery system obtained in this example were measured by a laser particle size analyzer to be 300-500 nm.

[0063]Drug loading test: use the monoclonal antibody kit to test the concentration of the monoclonal antibody in the dial...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a temperature sensitive-type hydrogel nano drug delivery system, which belongs to the technical field of a drug. The temperature sensitive-type hydrogel nano drug delivery system comprises temperature sensitive-type hydrogel, an anticancer drug or an anticancer drug inclusion, and an auxiliary agent; the temperature sensitive-type hydrogel comprises the following synthesis components by mole parts: 100 parts of N-isopropyl acrylamide, 15-35 parts of acrylic acid, 5-20 parts of N,N-methylene bisacrylamide, 1-3 parts of sodium dodecanesulphonate, 0.1-20 parts of an initiator, and 50-150 parts of water. The mol ratio of a monomer (N-isopropyl acrylamide and acrylic acid) to the anticancer drug or the anticancer drug inclusion to the auxiliary agent in the temperature sensitive-type hydrogel nano drug delivery system is 1: 0.05-10: 0.05-10. The temperature sensitive-type hydrogel nano drug delivery system is used for increasing the chemical treatment curative effect of solid tumor by simultaneously delivering the anticancer drug and the auxiliary agent to a place near the tumor and into the tumor.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a temperature-sensitive hydrogel nano drug delivery system. Background technique [0002] Cancer is the "number one killer" that threatens human health and has become the leading disease that causes human death. Due to population aging and environmental pollution, the incidence and total number of tumors are increasing year by year. Therefore, research on overcoming cancer is urgent! [0003] The current means of treating cancer can include: surgery, radiation, chemistry, traditional Chinese medicine and immunotherapy. Due to the limitations of modern medical technology, although surgical treatment removes the lesion, it has the disadvantages of weakening the patient's physique, promoting the proliferation and metastasis of cancer cells, and further exacerbating the risk of the disease. Surgical treatment is usually suitable for early and middle-stage cancer patien...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K45/06A61K47/32A61P35/00A61P35/04
CPCA61K9/0024A61K45/06A61K47/32
Inventor 潘君孔非田大伟岳丹阳于钊江周谨白玉英
Owner CHONGQING UNIV
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com