Temperature sensitive-type hydrogel nano drug delivery system

A temperature-sensitive, hydrogel nano-technology, applied in the field of medicine, to achieve the effect of improving the therapeutic effect, improving the curative effect, and uniform particle size

Active Publication Date: 2017-11-24
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the fact that is easily overlooked by people is that there are various barriers in the human body (lymphatic system, lysozyme, inter

Method used

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  • Temperature sensitive-type hydrogel nano drug delivery system
  • Temperature sensitive-type hydrogel nano drug delivery system
  • Temperature sensitive-type hydrogel nano drug delivery system

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0043] Example 1

[0044] Combine 100 parts of N-isopropylacrylamide (NIPAM), 35 parts of acrylic acid (AA), 5 parts of N,N-methylenebisacrylamide, 1 part of sodium lauryl sulfonate, ammonium persulfate / sulfurous acid 10 parts of sodium hydrogen, 60 parts of water, 10 parts of receptor tyrosine kinase inhibitor, 10 parts of anti-angiogenic agent, and 10 parts of propanol. Mix well, and remove the air in the reaction system at 0~50℃ for 0.1~2 hours , Under anaerobic conditions, heat the reaction system to 35-100°C for 4-20 hours to obtain the product;

[0045] 3) Centrifugal products are obtained by washing and centrifugation several times;

[0046] 4) Vacuum drying the product obtained in step 3) at 0-50°C to obtain a hydrogel nano drug delivery system.

[0047] Detection:

[0048] An infrared spectrophotometer was used to verify the polymerization reaction of the temperature-sensitive nanohydrogel. From the infrared spectrum analysis chart (see figure 1 ), it can be seen that the cu...

Example Embodiment

[0052] Example 2

[0053] 100 parts of N-isopropylacrylamide (NIPAM), acrylic acid (AA) (the molar ratio of N-isopropylacrylamide to acrylic acid is 98:2 / 95:5 / 92:8 / 90:10), 5 parts of N,N-methylene bisacrylamide, 1 part of sodium dodecyl sulfonate, 0.1 part of potassium persulfate, 50 parts of water, 10 parts of PI3K / mTOR / AKT inhibitor, and 10 parts of isopropanol. , Exclude the air in the reaction system at 0-50°C for 0.1-2 hours, and heat the reaction system to 35-100°C for 4-20 hours under anaerobic conditions to obtain the product;

[0054] 3) Centrifugation products obtained by washing and centrifugation several times;

[0055] 4) Vacuum drying the product obtained in step 3) at 0-50°C to obtain a hydrogel nanomedicine delivery system.

[0056] Detection:

[0057] The particle size of the nano-medicine delivery system obtained in this embodiment measured by a laser particle size analyzer is 100-300 nm.

[0058] Optimization of temperature-sensitive nano hydrogels: The light transmi...

Example Embodiment

[0059] Example 3

[0060] Combine 100 parts of N-isopropylacrylamide, 15 parts of acrylic acid, 20 parts of N,N-methylenebisacrylamide, 3 parts of sodium dodecyl sulfonate, 15 parts of ammonium persulfate initiator, 50 parts of water, After mixing 5 parts of monoclonal antibody anticancer drugs and 100 parts of glucose, the air in the liquid is removed at 25°C for 0.1 hour, and the reaction system is heated to 60°C for 8 hours under anaerobic conditions to obtain the product. The unencapsulated drugs or anti-cancer drug inclusions and auxiliary agents and unpolymerized small molecule materials are removed by dialysis and separation, and the hydrogel nano drug delivery system is obtained by vacuum drying at 25°C.

[0061] Detection:

[0062] The particle size of the nano-medicine delivery system obtained in this embodiment is determined to be 300-500 nm by a laser particle size analyzer.

[0063] Drug loading test: Use a monoclonal antibody kit to test the concentration of monoclonal ...

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Abstract

The invention discloses a temperature sensitive-type hydrogel nano drug delivery system, which belongs to the technical field of a drug. The temperature sensitive-type hydrogel nano drug delivery system comprises temperature sensitive-type hydrogel, an anticancer drug or an anticancer drug inclusion, and an auxiliary agent; the temperature sensitive-type hydrogel comprises the following synthesis components by mole parts: 100 parts of N-isopropyl acrylamide, 15-35 parts of acrylic acid, 5-20 parts of N,N-methylene bisacrylamide, 1-3 parts of sodium dodecanesulphonate, 0.1-20 parts of an initiator, and 50-150 parts of water. The mol ratio of a monomer (N-isopropyl acrylamide and acrylic acid) to the anticancer drug or the anticancer drug inclusion to the auxiliary agent in the temperature sensitive-type hydrogel nano drug delivery system is 1: 0.05-10: 0.05-10. The temperature sensitive-type hydrogel nano drug delivery system is used for increasing the chemical treatment curative effect of solid tumor by simultaneously delivering the anticancer drug and the auxiliary agent to a place near the tumor and into the tumor.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a temperature-sensitive hydrogel nano drug delivery system. Background technique [0002] Cancer is the "number one killer" that threatens human health and has become the leading disease that causes human death. Due to population aging and environmental pollution, the incidence and total number of tumors are increasing year by year. Therefore, research on overcoming cancer is urgent! [0003] The current means of treating cancer can include: surgery, radiation, chemistry, traditional Chinese medicine and immunotherapy. Due to the limitations of modern medical technology, although surgical treatment removes the lesion, it has the disadvantages of weakening the patient's physique, promoting the proliferation and metastasis of cancer cells, and further exacerbating the risk of the disease. Surgical treatment is usually suitable for early and middle-stage cancer patien...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K47/32A61P35/00A61P35/04
CPCA61K9/0024A61K45/06A61K47/32
Inventor 潘君孔非田大伟岳丹阳于钊江周谨白玉英
Owner CHONGQING UNIV
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