Temperature sensitive-type hydrogel nano drug delivery system
A temperature-sensitive, hydrogel nano-technology, applied in the field of medicine, to achieve the effect of improving the therapeutic effect, improving the curative effect, and uniform particle size
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[0043] Example 1
[0044] Combine 100 parts of N-isopropylacrylamide (NIPAM), 35 parts of acrylic acid (AA), 5 parts of N,N-methylenebisacrylamide, 1 part of sodium lauryl sulfonate, ammonium persulfate / sulfurous acid 10 parts of sodium hydrogen, 60 parts of water, 10 parts of receptor tyrosine kinase inhibitor, 10 parts of anti-angiogenic agent, and 10 parts of propanol. Mix well, and remove the air in the reaction system at 0~50℃ for 0.1~2 hours , Under anaerobic conditions, heat the reaction system to 35-100°C for 4-20 hours to obtain the product;
[0045] 3) Centrifugal products are obtained by washing and centrifugation several times;
[0046] 4) Vacuum drying the product obtained in step 3) at 0-50°C to obtain a hydrogel nano drug delivery system.
[0047] Detection:
[0048] An infrared spectrophotometer was used to verify the polymerization reaction of the temperature-sensitive nanohydrogel. From the infrared spectrum analysis chart (see figure 1 ), it can be seen that the cu...
Example Embodiment
[0052] Example 2
[0053] 100 parts of N-isopropylacrylamide (NIPAM), acrylic acid (AA) (the molar ratio of N-isopropylacrylamide to acrylic acid is 98:2 / 95:5 / 92:8 / 90:10), 5 parts of N,N-methylene bisacrylamide, 1 part of sodium dodecyl sulfonate, 0.1 part of potassium persulfate, 50 parts of water, 10 parts of PI3K / mTOR / AKT inhibitor, and 10 parts of isopropanol. , Exclude the air in the reaction system at 0-50°C for 0.1-2 hours, and heat the reaction system to 35-100°C for 4-20 hours under anaerobic conditions to obtain the product;
[0054] 3) Centrifugation products obtained by washing and centrifugation several times;
[0055] 4) Vacuum drying the product obtained in step 3) at 0-50°C to obtain a hydrogel nanomedicine delivery system.
[0056] Detection:
[0057] The particle size of the nano-medicine delivery system obtained in this embodiment measured by a laser particle size analyzer is 100-300 nm.
[0058] Optimization of temperature-sensitive nano hydrogels: The light transmi...
Example Embodiment
[0059] Example 3
[0060] Combine 100 parts of N-isopropylacrylamide, 15 parts of acrylic acid, 20 parts of N,N-methylenebisacrylamide, 3 parts of sodium dodecyl sulfonate, 15 parts of ammonium persulfate initiator, 50 parts of water, After mixing 5 parts of monoclonal antibody anticancer drugs and 100 parts of glucose, the air in the liquid is removed at 25°C for 0.1 hour, and the reaction system is heated to 60°C for 8 hours under anaerobic conditions to obtain the product. The unencapsulated drugs or anti-cancer drug inclusions and auxiliary agents and unpolymerized small molecule materials are removed by dialysis and separation, and the hydrogel nano drug delivery system is obtained by vacuum drying at 25°C.
[0061] Detection:
[0062] The particle size of the nano-medicine delivery system obtained in this embodiment is determined to be 300-500 nm by a laser particle size analyzer.
[0063] Drug loading test: Use a monoclonal antibody kit to test the concentration of monoclonal ...
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