A preparation method of nanoparticles embedded with anticancer drug-loaded carbon quantum dots
A technology of carbon quantum dots and nanoparticles, which is applied in the field of nanoparticle preparation, can solve the problem that the loading effect of carbon quantum dots is not ideal, and achieve the effect of improving the encapsulation rate and simplifying the experimental operation process
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Embodiment 1
[0033] 1) Add 400 mg of citric acid to 20 mL of hexadecylamine to obtain a mixed solution, which is sealed and stored.
[0034] 2) Add the mixture obtained in 1) to 60 mL of concentrated sulfuric acid (98wt%) and 25 mL of concentrated nitric acid (65wt%) mixed acid solution, and the mixture was first ultrasonically dispersed for 1 h, and then stirred at 100 °C Reflux for 24 h. The obtained solution was cooled to room temperature first, and then diluted with deionized water to a total volume of about 600 mL.
[0035] 3) Add sodium carbonate to 2) neutralize the excess acid until the pH of the solution is around 7.5. The obtained solution was concentrated by rotary evaporation, and a large amount of precipitated inorganic salts were removed by filtration. The collected filtrate was dialyzed with a dialysis bag (1000 Da) for 3 days to obtain an aqueous solution of pure carbon quantum dots.
[0036] 4) Add 10 mL of ammonia water and 10 mL of thionyl chloride to 30 mL of the carb...
Embodiment 2
[0046] 1) Add 450 mg of citric acid to 25 mL of hexadecylamine to obtain a mixture, which is sealed and stored.
[0047] 2) Add the mixture obtained in 1) to a mixture of 65 mL of concentrated sulfuric acid (98wt%) and 27 mL of concentrated nitric acid (65wt%). The mixture is first ultrasonically dispersed for 1 h, and then stirred and refluxed at 100°C 27 h. The obtained solution was first cooled to room temperature, and then diluted with deionized water to a total volume of about 700 mL.
[0048] 3) Add sodium carbonate to 2) neutralize the excess acid until the pH of the solution is around 8.0. The obtained solution was concentrated by rotary evaporation, and a large amount of precipitated inorganic salts were removed by filtration. The collected filtrate was dialyzed with a dialysis bag (1000 Da) for 3 days to obtain an aqueous solution of pure carbon quantum dots.
[0049] 4) Add 13 mL of ammonia water and 13 mL of thionyl chloride to 35 mL of the carbon quantum dot sol...
Embodiment 3
[0059] 1) Add 500 mg of citric acid to 30 mL of hexadecylamine to obtain a mixture, which is sealed and stored.
[0060] 2) Add the mixture obtained in 1) to a mixture of 70 mL of concentrated sulfuric acid (98wt%) and 30 mL of concentrated nitric acid (65wt%). The mixture is ultrasonically dispersed for 2 h, and then stirred and refluxed at 100°C 30 h. The obtained solution was first cooled to room temperature, and then diluted with deionized water to a total volume of about 800 mL.
[0061] 3) Add sodium carbonate to 2) neutralize the excess acid until the pH of the solution is around 8.5. The obtained solution was concentrated by rotary evaporation, and a large amount of precipitated inorganic salts were removed by filtration. The collected filtrate was dialyzed with a dialysis bag (1000Da) for 4 days to obtain an aqueous solution of pure carbon quantum dots.
[0062] 4) Add 15 mL of ammonia water and 15 mL of thionyl chloride to 40 mL of the carbon quantum dot solution o...
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