High-speed centrifugal atomization device

Abstract

The invention discloses a high-speed centrifugal atomization device. A structure of the device comprises a round plate, a connection part, and a power source; and the round plate has a bright and smooth surface, or the round plate is carved with concentric circles with depth of 0.01-1.50mm, the connection part is used to directly or indirectly connect the round plate with the power source, and the power source is a high-speed electrical machine, a pneumatic motor, or other high-rotation speed power element, and the speed can be controlled at 100-5000rpm. According to the high-speed centrifugal atomization device designed by the invention, through high-speed centrifugation, an atomization effect of which a fogdrop state is controllable is formed from a fluid. The device has the following concrete advantages: (1) the ideal atomization effect is achieved through the high-speed centrifugal mechanical rotation plate without introducing compressed air; (2) positive pressure does not exist, and powder material loss is completely avoided; (3) atomized fogdrop sizes are accurately controlled through a rotation speed and flux; and (4) possibility that the fluid contacts a stirring paddle and the rotation plate is completely avoided.

Description

technical field [0001] The invention relates to a high-speed centrifugal atomization device, in particular to a wet mixing granulator, a hot-melt spray granulator, a spray dryer, a centrifugal granulator, etc., and belongs to the field of pharmaceutical equipment. Background technique [0002] At present, in the field of pharmaceuticals, materials are often processed by wet granulation process, prepared into particles with good fluidity and compressibility, and then processed in the next step, such as tabletting or filling capsules, so it is necessary to introduce adhesive Wet granulation with additives or wetting agents. The conventional introduction methods are: manual pouring, peristaltic pump pumping, and compressed air atomization introduction. And these three types have corresponding defects: ①The viscous liquid cannot be atomized and introduced by compressed air, and can only be poured manually. In this way, it will cause local over-sticking and agglomeration, and the...

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Problems solved by technology

And these three types have corresponding defects: ①The viscous liquid cannot be atomized and introduced by compressed air, and can only be poured manually. In this way, it will cause local over-sticking and agglomeration, and the internal quality of the particles will be uneven after granulation , affecting the quality of finished products; ②Peristaltic pump pumping, although replacing the human factor, can not solve the phenomenon of local over-sticking and clumping; However, the introduction of compressed air introduces control risks in a disguised form, because the material will remain in contact with the compressed air during the liquid spraying process. In order to reduce the risk, it is necessary to carry out terminal quality control on the imported compressed air. In this way, the introduction of hardware ④Compressed air atomization makes the whole mixing granulation pot under positive pressure, which is easy to cause the loss of powder materials, and the phenomenon of spraying liquid to the bottom stirring paddle will also occur

[0003] In order to realize the taste masking of drugs, improve the dissolution rate of insoluble drugs, and improve the bioavailability, hot melt spray or spray drying methods are often used to meet the process requirements. Conventional hot melt spray or spray drying uses hot melt spray guns Or the conventional spray gun sprays the hot-melt solid dispersion or the conventional dispersion to spray granulation. The particle size requirement ≤150μm can basically be realized by this device, but the special particle size distribution requirements, such as 60-80 mesh (that is, 180- 250μm), it is difficult to achieve, the main reason is: spray gun atomization can only adjust the size of the formed droplets by the size of the atomization pressure, while the pressure adjustment is greatly affected by the liquid inlet speed, so it cannot be accurately realized ≥150μm particle size distribution

[0004] In order to make powder materials into pellets, screw extrusion spheronization, rotary extrusion spheronization, or centrifugal granulation are often used to meet the process requirements. Conventional centrifugal granulators use peristaltic pumps to pump the binder. , spray liquid in the way of compressed air atomization to realize the process of wetting, mothering, layer growth, and spheronization. The existing problem is: compressed air atomization makes the whole centrifugal granulation pot body under positive pressure, resulting in powder If the material is seriously lost, it will also be sprayed onto the round turntable, causing the phenomenon of sticking to the turntable

[0005] In order to solve the above problems, equipment manufacturers have modified their respective wet mixing granulators, hot melt spray granulators, spray dryers, and centrifugal granulators to varying degrees, but the essence of liquid atomization has not been changed. question

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