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Anti-bacterial modified nano composite material promoting osteogenesis growth and preparation method thereof

A nanocomposite material and bone-promoting technology, applied in tissue regeneration, medical science, prostheses, etc., can solve problems such as unfavorable new bone regeneration, prone to osteoporosis and secondary fractures, weak bonding, etc., and achieve osteocyte Fast proliferation and differentiation, promotion of cell adhesion, proliferation and differentiation, and the effect of stabilizing attachments

Inactive Publication Date: 2017-12-15
杨蕾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Medical titanium metal has good biocompatibility and excellent mechanical properties, and is widely used as implant materials such as dental implants and bone implants in the treatment of dentition defects, bone loss and other diseases. However, titanium metal is a biologically inert material. After entering the human body, its surface is not conducive to the regeneration of new bone, and the bonding between the new bone and the titanium surface is weak, and osteoporosis and secondary fractures are prone to occur. In order to improve the surface activity of the titanium implant and the synergy with its own bone , it is often necessary to functionalize the titanium surface

Method used

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  • Anti-bacterial modified nano composite material promoting osteogenesis growth and preparation method thereof
  • Anti-bacterial modified nano composite material promoting osteogenesis growth and preparation method thereof
  • Anti-bacterial modified nano composite material promoting osteogenesis growth and preparation method thereof

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Effect test

Embodiment 1

[0026] An antibacterial modified nanocomposite material for promoting osteogenic growth, the preparation steps of which are:

[0027] (1) Preparation of silver-loaded titanium nanomaterials

[0028] Silver-loaded titanium nanomaterials were formed by plasma immersion ion implantation with a vacuum of 2 × 10 -3 Pa, the negative voltage pulse is -30kV, the pulse duration is 700μs, the frequency is 10Hz, and the plasma immersion time is 1h, that is, silver-loaded titanium nanomaterials are obtained.

[0029] (2) Preparation of nanocomposite materials

[0030] Disperse the silver-loaded nanomaterial prepared in step (1) with 20 mL of ultrapure water, then add 50 μL of Tween 20, place it on an ultrasonic instrument for ultrasonic dispersion for 10 min, and then add graphene oxide, 10 nm alumina, 10nm apatite, fully stirred for 20 minutes, and then ultrasonically dispersed for 10 minutes to obtain a nanocomposite material, in which the percentage content of each monomer material i...

Embodiment 2

[0034] An antibacterial modified nanocomposite material for promoting osteogenic growth, the preparation steps of which are:

[0035] (1) Preparation of silver-loaded titanium nanomaterials

[0036] Silver-loaded titanium nanomaterials were formed by plasma immersion ion implantation with a vacuum of 2.5×10 -3 Pa, the negative voltage pulse is -40kV, the pulse duration is 780μs, the frequency is 12Hz, and the plasma immersion time is 1.5h, that is, silver-loaded titanium nanomaterials are obtained.

[0037] (2) Preparation of nanocomposite materials

[0038] Disperse the silver-loaded nanomaterial prepared in step (1) with 20 mL of ultrapure water, then add 50 μL of Tween 20, place it on an ultrasonic instrument for ultrasonic dispersion for 10 min, and then add graphene oxide, 15 nm magnesium oxide, 30nm apatite, fully stirred for 20 minutes, and then ultrasonically dispersed for 10 minutes to obtain a nanocomposite material, in which the percentage content of each monomer ...

Embodiment 3

[0042] An antibacterial modified nanocomposite material for promoting osteogenic growth, the preparation steps of which are:

[0043] (1) Preparation of silver-loaded titanium nanomaterials

[0044] Silver-loaded titanium nanomaterials were formed by plasma immersion ion implantation with a vacuum of 3 × 10 -3 Pa, the negative voltage pulse is -50kV, the pulse duration is 850μs, the frequency is 15Hz, and the plasma immersion time is 2h, that is, silver-loaded titanium nanomaterials are obtained.

[0045] (2) Preparation of nanocomposite materials

[0046] Disperse the silver-loaded nanomaterial prepared in step (1) with 20mL of ultrapure water, then add 50μL of Tween 20, place it on an ultrasonic instrument for ultrasonic dispersion for 10min, and then add graphene oxide and 20nm silicon dioxide under stirring. , 50nm apatite, fully stirred for 20 minutes, and then ultrasonically dispersed for 10 minutes to obtain a nanocomposite material, wherein the percentage content of ...

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Abstract

The invention discloses an anti-bacterial modified nano composite material promoting osteogenesis growth. The material is prepared from the components of 52-85% of silver carried titanium nano material, 24-56% of graphene oxide, 1-15% of nano ceramic material and 1-10% of nano apatite; PEG modification is performed and osteoblast growth contributing factors are loaded. The method is easy to operate, and the modified nano composite material has good biocompatibility and bone integrity, has a good anti-bacterial effect and strong mechanical property, makes bone cells proliferate and differentiate rapidly, and has low cell toxicity, thereby being a desired bone implant material and being capable of being applied to filling and repairing of various bone losses and bone injuries.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an antibacterial modified nanocomposite material for promoting osteogenesis and a preparation method thereof. Background technique [0002] Biomedical materials are widely used in the clinical field of orthopedics, especially in the treatment of bone injuries and defects, which further promotes the development of bone graft materials. When the bone graft material enters the body, it can not only replace the defective bone, but also provide a framework for regeneration and healing of the host's own bone cells and vascular network. As new bone, blood vessels, and soft tissue grow and connect the bone defect segments, the bone implant material should act as their scaffold, allowing the grafted area and bone implant to be stabilized. Therefore, it is necessary to prepare bone implant materials with advantages such as good mechanical properties, strong cell adhesion, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/06A61L27/08A61L27/10A61L27/12A61L27/18A61L27/54A61L27/50
CPCA61L27/047A61L27/06A61L27/08A61L27/10A61L27/12A61L27/18A61L27/50A61L27/54A61L2300/104A61L2300/404A61L2300/414A61L2430/02C08L71/02
Inventor 杨蕾
Owner 杨蕾
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