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Ultrasonic nano spray liquid preparation and preparation method thereof

A liquid preparation and nanotechnology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of low solubility, poor stability, and difficulty of coenzyme Q10, so as to increase skin moisture content, maintain skin elasticity, The effect that improves the absorption effect

Inactive Publication Date: 2017-12-22
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the extremely low solubility and poor stability of coenzyme Q10, it is difficult to form a preparation that is conducive to skin absorption by conventional methods

Method used

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  • Ultrasonic nano spray liquid preparation and preparation method thereof
  • Ultrasonic nano spray liquid preparation and preparation method thereof
  • Ultrasonic nano spray liquid preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A preparation method of ultrasonic nano spray liquid preparation, comprising the following steps:

[0054] Weigh MCT, Cremophor EL, and Transcutol respectively according to the ratio of 1:2:1, and mix them evenly. Take a 10mL EP tube, weigh more than 40mg of the mixed solution, and use it as the oil phase. Take 10 mL of purified water as the aqueous phase. Disperse the oil phase in the water phase, and stir at room temperature for 4 hours to obtain a nano-spray liquid preparation. Use an ultrasonic spray method to make the nano-emulsion form nano-scale fine droplets. The oscillation frequency of the ultrasonic spray method is 1.7MHz or 2.4MHz. The spray volume is 1.2-1.8mL / min, and the ultrasonic nano spray liquid preparation is obtained, which is named as F0. Wherein, the content of each component is as shown in table 1:

[0055] Content of each component in Table 1 F0

[0056]

Embodiment 2

[0058] Weigh MCT, Cremophor EL, and Transcutol respectively according to the ratio of 1:2:1, and mix them evenly. Take a 10mL EP tube and weigh more than 40mg of the mixed solution. Weigh 1 mg of coenzyme Q10 (CoQ10) into an EP tube, heat it in a water bath at 50°C to dissolve, and it becomes the oil phase. Take 10 mL of purified water as the aqueous phase. Disperse the oil phase in the water phase, and stir at room temperature for 4 hours to obtain a nano-spray liquid preparation. Use an ultrasonic spray method to make the nano-emulsion form nano-scale fine droplets. The oscillation frequency of the ultrasonic spray method is 1.7MHz or 2.4MHz. The spray volume was 1.2-1.8mL / min, and the ultrasonic nano spray liquid preparation was obtained, which was named as F1. Wherein, the content of each component is as shown in table 2:

[0059] Table 2 Contents of each component in F1

[0060]

Embodiment 3

[0062] According to the method of Example 2, the ultrasonic nano-spray liquid preparation was prepared, which was named as F2. The difference from Example 2 is that 105 mg of coenzyme Q is weighed. Wherein, the content of each component is as shown in table 3:

[0063] Content of each component in Table 3 F2

[0064]

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Abstract

The invention relates to an ultrasonic nano spray liquid preparation, which is prepared from the following components in parts by weight: 1-10 parts of coenzyme Q10, 1-100 parts of hyaluronic acid, 1-20 parts of an oil phase material, 2-20 parts of an emulsifier, 1-100 parts of a co-emulsifier and 100-10000 parts of ethanol and / or water, wherein the oil phase material is one or a combination of more of medium chain triglyceride (MCT), vitamin E and soybean oil; the emulsifier is one or a combination of more of castor oil polyoxyethylene ether, hydrogenated castor oil poly(hydrocarbon oxygen ester) 40 and Tween-80; the co-emulsifier is one or a combination of more of diethylene glycol monoethyl ether, labrasol and caprylic capric triglyceride. The invention also provides a preparation method of the ultrasonic nano spray liquid preparation; the method comprises the following steps: evenly mixing the oil phase material, the emulsifier, the co-emulsifier and the coenzyme Q10 so as to obtain a mixed oil phase; dissolving hyaluronic acid into a solvent to obtain a water phase; dispersing the mixed oil phase into the water phase, and carrying out ultrasonic dispersion. The ultrasonic nano spray liquid preparation is stable in performance; nanoscale fine fogdrops are enabled to permeate the skin deep in a form of ultrasonic spray, so that the skin absorption of the coenzyme Q 10 and the hyaluronic acid is improved.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to an ultrasonic nano-spray liquid preparation and a preparation method thereof. Background technique [0002] Skin aging is caused by the increase of physiological age and long-term exposure to the external environment, such as metabolism, or oxidative free radicals produced by ultraviolet radiation, which attack cell membrane lipids and induce oxidation, further destroying cells, resulting in skin aging. Symptoms are hyperpigmentation, decreased skin moisture retention, rough skin, and increased wrinkles. With the pursuit of modern quality of life, the research and development of beauty products to prevent or delay aging is actively going on. [0003] The skin is divided into two layers: the epidermis and the dermis. The stratum corneum is the outermost layer of the epidermis and is the most important barrier for transdermal transport of most substances. Ultrasonic spray can enter the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/35A61K8/06A61K8/04A61Q19/00
CPCA61K8/046A61K8/062A61K8/355A61K8/735A61K2800/21A61K2800/82A61K2800/87A61Q19/007A61Q19/08
Inventor 曹青日黄豪雁
Owner SUZHOU UNIV
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