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Artificial intervertebral disc based on polymethylmethacrylate and preparation method thereof

A technology of polymethyl methacrylate and intervertebral discs, applied in coatings, medical science, prostheses, etc., can solve problems such as inflammatory response, high overall mechanical strength, and stress concentration, so as to increase the angle of movement and degree of freedom, and improve Mechanical properties, the effect of increasing Young's modulus

Inactive Publication Date: 2017-12-22
巩天星
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Intervertebral discs usually have a service life of 40 years, and material degradation will lead to failure of the intervertebral disc and require reoperation to repair, which virtually increases the pain and risk of patients
At the same time, the mechanical strength of the metal endplate is different from that of the polymer interdisc. During daily relative movement, the wear of the interdisc will be accelerated, polymer particles will be released, and inflammation will be caused.
[0009] At present, the commonly used one-piece artificial intervertebral disc is usually made of metal material, and the overall mechanical strength is too large, resulting in stress concentration. At the same time, it is limited by the characteristics of the metal material, lacks flexibility, and cannot fully simulate the range of motion of the original intervertebral disc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] an artificial intervertebral disc

[0053] The raw material formula of the end plate: by weight percentage, 90% low molecular weight polymethyl methacrylate (Mr=9000), 10% dicalcium silicate.

[0054] The raw material formula of the disc: by weight percentage, 70% high molecular weight polymethyl methacrylate (Mr=10000), 30% chitin.

[0055] Production Method:

[0056] 1. Make the end plate:

[0057] Mix all the raw materials of the endplate, add appropriate amount of N,N-dimethyl-m-toluidine to make a paste.

[0058] Pour the mixed paste into the preset mold. Close and lock the mold at room temperature and wait for 1 to 2 hours, then open the mold and take out the end plate.

[0059]A bioactive dicalcium silicate bioceramic coating is added to the surface of the prepared polymethyl methacrylate end plate, thereby increasing the biological fusion between the end plate and the vertebrae and improving the postoperative healing effect. Prepare dicalcium silicate into ...

Embodiment 2

[0067] an artificial intervertebral disc

[0068] The raw material formula of the end plate: by weight percentage, 90% low molecular weight polymethyl methacrylate (Mr=9000), 10% tricalcium silicate.

[0069] The raw material formula of the disc: by weight percentage, 70% high molecular weight polymethyl methacrylate (Mr=100000), 15% chitin, 15% carboxymethyl chitosan.

[0070] Production Method:

[0071] 1. Make the end plate:

[0072] Mix all the raw materials of the endplate, add appropriate amount of N,N-dimethyl-m-toluidine to make a paste.

[0073] Pour the mixed paste into the preset mold. Close and lock the mold at room temperature and wait for 1 to 2 hours, then open the mold and take out the end plate.

[0074] A biologically active tricalcium silicate bioceramic coating is added to the surface of the prepared polymethyl methacrylate end plate, thereby increasing the biological fusion of the end plate and the vertebrae and improving the postoperative healing effe...

Embodiment 3

[0079] an artificial intervertebral disc

[0080] The raw material formula of the end plate: by weight percentage, 90% low molecular weight polymethyl methacrylate (Mr=8000), 8% dicalcium silicate, 2% calcium dihydrogen phosphate.

[0081] The raw material formula of the disc: by weight percentage, 70% high molecular weight polymethyl methacrylate (Mr=50000), 20% chitin, 10% carboxymethyl chitosan.

[0082] Production Method:

[0083] 1. Make the end plate:

[0084] Mix all the raw materials of the endplate, add appropriate amount of N,N-dimethyl-m-toluidine to make a paste.

[0085] Pour the mixed paste into the preset mold. Close and lock the mold at room temperature and wait for 1 to 2 hours, then open the mold and take out the end plate.

[0086] Add bioactive dicalcium silicate and calcium dihydrogen phosphate bioceramic coatings on the surface of the prepared polymethyl methacrylate end plate, so as to increase the biological fusion between the end plate and the vert...

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PUM

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Abstract

The invention provides an artificial intervertebral disc based on polymethylmethacrylate and a preparation method thereof. The artificial intervertebral disc based on the polymethylmethacrylate comprises: a terminal plate which is mainly prepared from low molecular polymethylmethacrylate, and an intercalated disc which is mainly prepared from high molecular polymethylmethacrylate and a biodegradable biopolymer at the mass ratio ranging from (5 to 1) to (3 to 1), wherein the molecular weight of the low molecular polymethylmethacrylate is less than 10000; the molecular weight of the high molecular polymethylmethacrylate is 10000 to 100000; the biodegradable biopolymer comprises polylactic acid and / or a polysaccharide material. The artificial intervertebral disc provided by the invention is close to an original intervertebral disc of a human body and can be used for effectively replacing a disabled human body intervertebral disc and recovering an original biomechanical function of a vertebral column.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an artificial intervertebral disc based on polymethyl methacrylate and a preparation method thereof. Background technique [0002] With age, the nucleus pulposus in the intervertebral disc gradually loses water and degenerates, which leads to the concentration of force on the surrounding fibrous annulus, causing tear damage. If the tearing part in fibrosis cannot repair itself in time, the annulus fibrosus becomes permanent damage. During daily activities, the nucleus pulposus in the intervertebral disc will be continuously squeezed, protruding from the damaged part, compressing the intervertebral nerve, and causing vertebral damage. Intermittent pain seriously affects the quality of life and daily activities. [0003] The original intervertebral bone graft fusion is a classic way to treat intervertebral diseases. The purpose of bone graft fusion is to fill the gap ...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/18A61L27/20A61L27/30A61L27/32A61L27/50A61L27/58
CPCA61L27/16A61L27/18A61L27/20A61L27/306A61L27/32A61L27/50A61L27/58A61L2430/38C08L33/12C08L67/04
Inventor 巩天星
Owner 巩天星
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