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Method of boron nitride nanoparticle fabrication for antitumor drug delivery

An anticancer drug and nanoparticle technology, applied in the field of nanomedicine, can solve the problems of low intake, toxicity, and unfavorable cell absorption of boron nitride, so as to avoid cytotoxicity and increase efficiency

Active Publication Date: 2018-01-02
FEDERALNOE GOSUDARSTVENNOE AVTONOMNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO OBRAZOVANIYA NATSIONALNYJ ISSLEDOVATELSKIJ TEKHNOLOGICHESKIJ UNIV MISIS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] The main disadvantage of this method is that the morphology of boron nitride is not conducive to cellular uptake
Cellular uptake of nanotube-shaped particles is known to be modest, and they can be toxic

Method used

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  • Method of boron nitride nanoparticle fabrication for antitumor drug delivery
  • Method of boron nitride nanoparticle fabrication for antitumor drug delivery

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Experimental program
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Effect test

Embodiment 1

[0082] Spherical boron nitride nanoparticles were synthesized by chemical vapor deposition in a vertical induction furnace VIN-1,6-20 (Vac ETO, Russia). A powder mixture (10.88g in mass) containing 59wt.% iron oxide, 12wt.% magnesia and 29wt.% amorphous boron was thoroughly mixed and evenly put into a crucible, which was then placed in a furnace. The working chamber of the reactor is heated to 300°C, and the water and oxygen adsorbed on the surface of the working chamber are removed by using a permanent vacuum pump. The chamber was then filled with argon to atmospheric pressure. After the furnace was heated to 850°C, the transport gas argon and ammonia reaction gas streams were turned on. After heating to 1310°C, the temperature was kept constant for 200 minutes. After the synthesis is over, the studio is cooled to 40-50°C and then ventilated with air and openings.

[0083] After synthesis, 280 mg of snow-white fluffy powder was obtained. According to scanning electron mic...

Embodiment 2

[0089] A powder mixture with a mass of 11.76 g was put into the crucible of the reactor, the powder mixture containing 78 wt.% boric acid, 4 wt.% magnesium oxide and 18 wt.% amorphous boron. After the reactor was preliminarily removed from impurities, it was filled with an inert gas, heated to the working temperature and delivered transport gas and reaction gas (method in Example 1), the working temperature was 1190° C. and kept constant for 320 minutes. After synthesis, 345 mg of snow-white fluffy powder was obtained, which was an aggregate of boron nitride nanoparticles with a diameter of 70-100 nm.

[0090] The boron nitride aggregates were sonicated for 30 min at 80 W in distilled water. The concentration of boron nitride nanoparticles was 2 mg / ml. Particle size distribution studies showed that the amount of nanoparticles and their aggregates with a size greater than 250 nm was less than 1%.

[0091] In the 5 mg / ml doxorubicin aqueous solution, the boron nitride nanopart...

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Abstract

This invention relates to the technical field of nanomedical technologies, namely to the fabrication of nanocarriers of drugs for antitumor chemotherapy. The technical effects of the invention consistof increasing the efficiency of antitumor chemotherapy by increasing the activity of the cell absorption of nanocontainers loaded with an antitumor drug, avoiding of the nanocontainer toxicity for cells due to the use of dispersed boron nitride nanoparticles of 50-300 nm in diameter with a well-developed outer surface. The technical effects are achieved as follows. The method of boron nitride nanoparticles fabrication for antitumor drug delivery to tumor cells includes synthesis of spherical boron nitride nanoparticles of 50-300 nm in diameter with a well-developed outer surface by chemical vapor deposition using ammonia reaction gas, argon transport gas and powder mixture composed of amorphous boron and oxidizing reactants. Chemical deposition is carried out under the following conditions: 1000<=T<=1430, and 1.2<= Xi<=8, wherein T is the temperature of the powder mixture, the Xi is the ratio of the specific flows FAr / FNH3, the FAr is the specific flow of the transport gas and the FNH3 is the specific flow of the reactant gas. The ultrasonic treatment of BN nanoparticles agglomeration is realized followed by saturation of nanoparticles with antitumor drug by sorption and washing in distilled water.

Description

technical field [0001] The present invention relates to nanomedicine technology, and more specifically, to improvements in nanoformulations for the delivery of anticancer chemotherapeutic drugs. [0002] During the treatment of cancer patients, the reduced efficiency of anticancer chemotherapy is mainly attributed to the development of malignant tumors and the generation of so-called multidrug-resistant tumor cells with the development of tumors. Activation of membrane transport factors for drug removal from cells. Also, many drugs used to treat tumors are low hydrophilic and have toxic effects on healthy body tissues. One approach to address these issues is to use nanotransport formulations to deliver drugs into tumor cells. Background technique [0003] A method for obtaining spherical boron nitride nanoparticles by chemical vapor deposition is known (US20110033707, published on February 10, 2011). The method can obtain boron nitride nanoparticles with a diameter less t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/04A61K45/00A61P35/00B82B3/00B82Y5/00
CPCB82Y5/00A61K9/5115A61K9/5192A61K47/6923A61K47/6929A61K9/143A61K31/704A61P35/00B82B3/00
Inventor 德米特里·弗拉基米罗维奇·施坦斯基安德烈·米哈伊洛维奇·科瓦尔斯基安德烈·特罗菲莫维奇·马特维耶夫伊丽娜·维克托罗芙娜·苏霍鲁科娃纳塔莉亚·亚历山德罗芙娜·格卢尚科娃伊丽娜·尤里耶芙娜·日特尼亚克
Owner FEDERALNOE GOSUDARSTVENNOE AVTONOMNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO OBRAZOVANIYA NATSIONALNYJ ISSLEDOVATELSKIJ TEKHNOLOGICHESKIJ UNIV MISIS
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