Degradable polyurethane biological material and preparation method thereof

A biomaterial and polyurethane technology, applied in the field of degradable polyurethane biomaterials and its preparation, can solve the problems of slow degradation rate, low melting point, strong hydrophobicity, etc., and achieve easy processing and molding, excellent mechanical properties, and good thermal stability Effect

Inactive Publication Date: 2018-01-19
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the disadvantages of high crystallinity, poor strength, low melting point, strong hydrophobicity and slow degradation rate of polycaprolactone as a biodegradable material in the medical field, the purpose of the present invention is to provide a biocompatible A biodegradable polyurethane biomaterial applied to soft tissue engineering with good properties, excellent mechanical properties, easy processing and controllable degradation rate and its preparation method

Method used

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  • Degradable polyurethane biological material and preparation method thereof
  • Degradable polyurethane biological material and preparation method thereof
  • Degradable polyurethane biological material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] In a three-neck flask equipped with a stirring device and protected by a nitrogen atmosphere, 32g of polyε-caprolactone diol 1000 and 16g of polyethylene glycol 2000 through vacuum dehydration were added dropwise to 30.4g of isophorone diisocyanate , reacted for 3 hours at 75°C; added 10g of dimethyl carbonate and 0.2g of dibutyltin dilaurate, added 7.9g of 1,4-butanediol, and reacted for 4h at 65°C to obtain polyurethane solution; after adding 60 g of dimethyl carbonate to adjust the concentration of the solution, cast the polyurethane solution on a polytetrafluoroethylene mold, and volatilize the solvent in a fume hood at room temperature to a constant weight to obtain the desired polyurethane film.

Embodiment 2

[0027] In a three-neck flask equipped with a stirring device and protected by a nitrogen atmosphere, 32g of polyε-caprolactone diol 1000 and 8g of polyethylene glycol 1000 through vacuum dehydration were added dropwise to 30.4g of isophorone diisocyanate , under the condition of 80°C, react for 2h; after adding 10g of dimethyl carbonate and 0.2g of dibutyltin dilaurate, add 7.9g of 1,4-butanediol, and react for 4h under the condition of 70°C to obtain polyurethane solution; after adding 50 g of dimethyl carbonate to adjust the concentration of the solution, cast the polyurethane solution on a polytetrafluoroethylene mold, and volatilize the solvent in a fume hood at room temperature to constant weight to obtain the required polyurethane film.

Embodiment 3

[0029] In a three-neck flask equipped with a stirring device and protected by a nitrogen atmosphere, 64g of polyε-caprolactone diol 2000 and 16g of polyethylene glycol 2000 through vacuum dehydration were added dropwise to 30.4g of isophorone diisocyanate , under the condition of 80°C, react for 3h; after adding 15g of dimethyl carbonate and 0.3g of dibutyltin dilaurate, add 7.9g of 1,4-butanediol, and react for 5h under the condition of 70°C to obtain polyurethane solution; after adding 60 g of dimethyl carbonate to adjust the concentration of the solution, cast the polyurethane solution on a polytetrafluoroethylene mold, and volatilize the solvent in a fume hood at room temperature to a constant weight to obtain the desired polyurethane film.

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Abstract

The invention discloses a degradable polyurethane biological material and a preparation method thereof. The degradable polyurethane biological material is prepared from the following components in parts by weight: 7.8 to 19 percent of poly epsilon-caprolactone (PCL), 3 to 15.6 percent of polyethylene glycol (PEG), 12.8 to 13.8 percent of isocyanate, 3.1 to 4.1 percent of a chain extender, 0.09 to0.11 percent of a catalyst and 57.6 to 63 percent of a green solvent, wherein isophorone diisocyanate (IPDI), hexamethylene diisocyanate (HDI), dicyclohexyl methane diisocyanate (HMDI) or mixed isocyanate of more than two of the above materials is adopted as the isocyanate. The preparation method comprises the following steps: blending according to the proportion of the raw materials, adding the vacuum-dried PCL and PEG into the isocyanate dropwise, reacting at 70 to 85 DEG C for 2 to 3 hours, adding the solvent and the catalyst, adjusting the temperature to be 55 to 65 DEG C, adding the chainextender, performing chain-extending reaction for 4 to 5 hours, casting the obtained polyurethane solution on a polytetrafluoroethylene mold, and naturally volatilizing the solvent in a ventilation kitchen to prepare a polyurethane film.

Description

technical field [0001] The invention relates to a degradable biomaterial, in particular to a biodegradable biodegradable polyurethane biomaterial used in soft tissue engineering and a preparation method thereof. Background technique [0002] The research on polymer materials used to prepare biodegradable biomaterials is becoming more and more perfect. Most of the early degradable polymer materials were hydrolytically degradable polyester polymers, such as polylactic acid, polycaprolactone, polyglycolic acid, etc. Due to the limitations of physical and mechanical properties of this type of materials, the degradation products have a large change in the pH value of the environment, and the degradation rate is uncontrollable, so the application range is limited. As a typical block polymer, polyurethane can be grafted with degradable segments to prepare degradable polymers. At the same time, the microphase separation structure produced by the thermodynamic incompatibility betwee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/75C08G18/66C08G18/42C08G18/48C08G18/32C08G18/08C08J5/18C08L75/06C08L75/08
Inventor 何素芹刘浩刘文涛王玉杰朱诚身王帅张培张曼曼
Owner ZHENGZHOU UNIV
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