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Polyaspartic acid derivative and synthetic method thereof

A polyaspartic acid and synthesis method technology, applied in the field of new polyaspartic acid materials and its synthesis, can solve the problems of high cost, complicated process, uncontrollable molecular weight of polyaspartic acid, etc., and achieve controlled polymerization High degree, simplified process steps, easy to be degraded by microorganisms

Inactive Publication Date: 2018-01-19
苏州美瑞姿生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above method can achieve a certain grafting rate, there are disadvantages such as complex process, high cost, and the molecular weight of the obtained polyaspartic acid cannot be adjusted.

Method used

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  • Polyaspartic acid derivative and synthetic method thereof
  • Polyaspartic acid derivative and synthetic method thereof
  • Polyaspartic acid derivative and synthetic method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 11

[0041] Example 11: According to Example 2, 100 parts of L-aspartic acid was polymerized for 4 hours in a kneading reactor under the condition of 175°C vacuum degree-20kPa, and then 50 parts of glycosylacetamide was added to carry out a modified ring-opening reaction , After continuing to react for 2h, the polysuccinimide grafted modified product was obtained. Add 3 mol / L aqueous sodium hydroxide solution dropwise to the succinimide modified product obtained by the reaction, hydrolyze for 2.5 hours at 50°C, and obtain polyaspartic acid grafted with glycosyl acetamide after the reaction is completed Derivatives sodium salt solution. The consumption of potassium hydroxide aqueous solution is as the criterion after the pH value of control system is between 8.5~9.5 after finishing the reaction. After subsequent purification steps such as filtration and ultrafiltration, the finally obtained polyaspartic acid derivative saline solution has a mass content greater than or equal to 25%...

Embodiment 12

[0042] Example 12: According to Example 5, 300 parts of L-aspartic acid was polymerized in a kneading reactor at 190°C under the condition of vacuum degree-35kPa for 2 hours, and then 250 parts of glycosylacetamide was added to carry out a modified ring-opening reaction , After continuing to react for 2.5h, a polysuccinimide grafted modified product was obtained. Add 2.5 mol / L aqueous sodium hydroxide solution dropwise to the succinimide modified product obtained by the reaction, hydrolyze at 45°C for 3 hours, and obtain polyaspartic acid grafted with glycosyl acetamide after the reaction is completed Derivatives sodium salt solution. The consumption of potassium hydroxide aqueous solution is as the criterion between 8.5~9.5 with the pH of control system after finishing the reaction. After subsequent purification steps such as filtration and ultrafiltration, the finally obtained polyaspartic acid derivative saline solution has a mass content greater than or equal to 20%, and ...

Embodiment 13

[0043] Example 13: According to Example 7, 150 parts of L-aspartic acid was polymerized for 2.5 hours in a kneading reactor at 205°C under the condition of vacuum degree -50kPa, and then 25 parts of glycosylacetamide was added to carry out modification and ring opening The reaction was continued for 3.5 hours to obtain a modified polysuccinimide graft. Add 5 mol / L aqueous sodium hydroxide solution dropwise to the succinimide modified product obtained by the reaction, hydrolyze at 60°C for 6 hours, and obtain polyaspartic acid derivatives grafted with glycosyl acetamide after the reaction is completed. Sodium saline solution. The consumption of potassium hydroxide aqueous solution is as the criterion after the pH value of control system is between 8.5~9.5 after finishing the reaction. After subsequent purification steps such as filtration and ultrafiltration, the finally obtained polyaspartic acid derivative saline solution has a mass content greater than or equal to 35%, and ...

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Abstract

The invention provides a polyaspartic acid derivative synthetic method. The method comprises the following steps: monosaccharide or disaccharide and monochloro acetic acid are reacted under catalysisof NaOH, and a reactant is subjected to further acidifying and purification to obtain carboxymethyl saccharide; carboxymethyl saccharide and diamine are subjected to dehydration condensation under catalysis of phosphoric acid to obtain glycosyl acetyl diamine; L-aspartic acid and phosphoric acid are respectively added in a kneading reactor for mixing, a mixture is stirred and heated, polymerization is carried out for preset time to obtain polysuccinimide; glycosyl acetyl diamine is added in a reaction vessel of polysuccinimide for a reaction, polysuccinimide is subjected to ring-opening and grafting reaction to obtain a polysuccinimide derivative; the polysuccinimide derivative is added in a hydrolysis kettle, an aqueous solution of alkali is add drop by drop, a hydrolysis reaction is carried out, and a liquid-phase product after hydrolysis is a glycosyl acetyl diamine-grafted modified polyaspartate aqueous solution. The synthetic method is simple and easy to operate, a grafting modification step and a polymerization step are coupled, so that the side-chain grafting rate is increased and the polymericular weight can be regulated and controlled.

Description

technical field [0001] The invention relates to a synthesis method of a new graft-modified polyaspartic acid material, in particular to a new polyaspartic acid material with glycosyl acetyl diamide as a modifier and a synthesis method thereof. Background technique [0002] Polyaspartic acid (PASP) is the first green chemical synthesized and industrialized in recent decades. It was awarded the first "President's Green Chemistry Challenge Award" by the Environmental Protection Agency for its excellent performance in industry and agriculture. Polyaspartic acid is a polymeric amino acid with a carboxylic acid side chain, which is generally obtained by dehydration condensation of the amine group and carboxyl group of the aspartic acid monomer to generate a peptide bond. It is a macromolecule with a protein structure peptide. Because of its excellent ion chelating ability and super hydrophilic ability, polyaspartic acid has been widely used in many fields such as industry, agricu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/10
Inventor 吴有庭陈雷庄薇娜
Owner 苏州美瑞姿生物科技有限公司
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