Polyurethane/liquid crystal compound biological material, and preparation method and application thereof

A composite biomaterial and composite material technology, applied in the field of new polyurethane/liquid crystal composite materials and their preparation, can solve problems such as rarely reported, staying in small molecular liquid crystals, etc., to achieve improved biocompatibility, avoid toxicity problems, and good elasticity Effect

Active Publication Date: 2018-02-09
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For liquid crystal materials, the current research mainly stays in the preparation and characterization of small molecule liquid crystals, but there are few reports on their biological properties and polymer liquid crystal materials.

Method used

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  • Polyurethane/liquid crystal compound biological material, and preparation method and application thereof
  • Polyurethane/liquid crystal compound biological material, and preparation method and application thereof
  • Polyurethane/liquid crystal compound biological material, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Prepare polyurethane / liquid crystal composite film by solvent evaporation method, comprising the following steps

[0051] (1) Configuration of the solution:

[0052] Accurately weigh 0.64 side chain polymer liquid crystal products, add 8.56g of chloroform solution in the Erlenmeyer flask and stir at 100r / min until fully dissolved, add 0.8g of polyurethane, continue stirring until completely dissolved to obtain mixed solution a (polyurethane concentration is 8%) , The liquid crystal / polyurethane mass ratio is 80%). Accurately weigh 0.2g of cholesteryl undecylenate, add 9g of chloroform solution to the Erlenmeyer flask and stir at a speed of 100r / min until completely dissolved, add 0.8g of polyurethane and continue stirring until completely dissolved to obtain mixed solution b. Accurately weigh 0.14g of cholesteryl undecylenate, add 9.06g of chloroform solution to the Erlenmeyer flask and stir at a speed of 100r / min until it is completely dissolved, add 0.8g of polyureth...

Embodiment 2

[0058] A preparation method of polyurethane / liquid crystal electrospinning fiber, comprising the following steps

[0059] (1) Preparation of solution:

[0060] Accurately weigh 0.64 side chain polymer liquid crystal products, add 6.84g of chloroform and 1.71g of N-N solution to the Erlenmeyer flask and stir at 100r / min until completely dissolved, add 0.8g of polyurethane, and continue stirring until completely dissolved to obtain a mixed solution A ( The polyurethane concentration is 8%, and the liquid crystal / polyurethane mass ratio is 80%). Accurately weigh 0.2g of cholesteryl undecylenate, add 7.2g of chloroform and 1.8g of N-N dimethylformamide into the Erlenmeyer flask, stir at a speed of 100r / min until it is completely dissolved, add 0.8g of polyurethane and continue Stir until completely dissolved to obtain mixed solution B. Accurately weigh 0.14g of cholesterol, add 7.24g of chloroform and 1.81g of N-N dimethylformamide to the Erlenmeyer flask and stir at a speed of ...

Embodiment 3

[0064] 3D printing prepares the method for polyurethane / liquid crystal composite material, comprises the following steps:

[0065] (1) Accurately weigh 0.56g of side chain polymer liquid crystal product, add 8.74g of chloroform solution to the Erlenmeyer flask and stir at 100r / min until completely dissolved, add 0.7g of polyurethane, and continue stirring until completely dissolved to obtain a polyurethane concentration of 7%. , a mixed solution with a liquid crystal / polyurethane mass ratio of 40%. Draw 5mL of solution with a syringe, install the syringe on the micro-injection pump, connect the syringe pump and the 3D printer, set the 3D printing parameters, run the printing at an extrusion speed of 20 μmL / min, and print for 30 minutes to obtain a grid-like 3D printed polyurethane / Liquid crystal composite film materials such as Figure 7 shown.

[0066] (2) Accurately weigh 50g of polyurethane particles and 40g of side chain polymer liquid crystals and mix them evenly, pou...

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Abstract

The invention discloses a polyurethane / liquid crystal compound material, and a preparation method and application thereof. The preparation method of the polyurethane / liquid crystal compound biologicalmaterial comprises the following steps: (1) preparing side-chain high-molecular liquid crystals; and (2) preparing the polyurethane / liquid crystal compound material through a solvent volatilization method or a 3D printing method or an electrostatic spinning method. For the polyurethane / liquid crystal compound material, the tensile modulus of elasticity is 0.025-0.53 MPa, the compressive modulus of elasticity is 1.67-4.10 MPa, and the maximum elongation percentage of the film material is up to 700-900%. The compound material disclosed by the invention has favorable elastic properties, favorable liquid crystal properties, favorable biological properties and an adjustable degradation rate, and can be favorably used for mechanical conduction and used for research on a mechanical microenvironment.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and in particular relates to a novel polyurethane / liquid crystal composite material and its preparation method and application. Background technique [0002] It has been more than 50 years since polyurethane was first used in the field of biomedical engineering in the middle of the 20th century. As a polymer material with good biocompatibility and mechanical properties, medical polyurethane is currently widely used in the field of tissue engineering. A large number of animal experiments and acute and chronic toxicity experiments have confirmed that medical polyurethane is non-toxic, non-distorting, and has no local irritation and allergic reactions. In particular, with the progress and development of social science and technology in recent years, the performance of polyurethane has been improved. In addition to continuous improvement, its applications have gradually expanded to various fields s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L75/08C08L83/06C08J5/18C08J9/26C08G77/38A61L27/46A61L27/50A61L27/56A61L27/58D01D5/00D04H1/4358D04H1/728B33Y80/00
CPCA61L27/46A61L27/50A61L27/56A61L27/58A61L2430/02B33Y80/00C08G77/38C08J5/18C08J9/0061C08J9/26C08J2201/0422C08J2201/0446C08J2207/10C08J2375/08C08J2483/06D01D5/003D01D5/0092D04H1/4358D04H1/728C08L75/08C08L83/06
Inventor 李娜周长忍李立华
Owner JINAN UNIVERSITY
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