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Loperamide hydrochloride capsules and preparation method thereof

A technology for loperamide hydrochloride and capsules, applied in the field of loperamide hydrochloride capsules and preparation thereof, can solve the problems of complex preparation components, low availability of loperamide hydrochloride, inability to exert drug effect, and the like, and achieve bioavailability. The effect of high intensity, stable active ingredient and fast release speed

Inactive Publication Date: 2018-03-02
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing preparations with loperamide hydrochloride as the main component have complex ingredients, which affect the dissolution rate of loperamide hydrochloride, make loperamide hydrochloride have a low availability in the body, and cannot exert the desired drug effect
Due to the above problems, when used clinically for the treatment of patients with diarrhea, the therapeutic effect will be affected to a certain extent

Method used

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  • Loperamide hydrochloride capsules and preparation method thereof
  • Loperamide hydrochloride capsules and preparation method thereof
  • Loperamide hydrochloride capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The medicament granules include the following raw materials in parts by weight:

[0025]

[0026] Include the raw material of following parts by weight in described hollow capsule:

[0027]

Embodiment 2

[0029] The medicament granules include the following raw materials in parts by weight:

[0030]

[0031]

[0032] Include the raw material of following parts by weight in described hollow capsule:

[0033]

Embodiment 3

[0035] The medicament granules include the following raw materials in parts by weight:

[0036]

[0037] Include the raw material of following parts by weight in described hollow capsule:

[0038]

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PUM

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Abstract

The invention provides a loperamide hydrochloride capsule and a preparation method thereof. The loperamide hydrochloride capsule includes drug granules and hollow capsules, wherein the drug granules not only have a very high curative effect on treating non-infectious acute and chronic diarrhea. Glucose can guarantee the needs of metabolizing heat when patients are extremely weak. Pregelatinized starch can be completely dissolved in cold water and has a self-lubricating effect. Magnesium stearate is added as a lubricant, which is non-toxic and non-irritating. The loperamide hydrochloride capsule has the characteristics of simple raw materials and auxiliary materials, high bioavailability, stable active ingredients and fast release speed of active ingredients.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a loperamide hydrochloride capsule and a preparation method thereof. Background technique [0002] The chemical name of loperamide hydrochloride is N,N-dimethyl-α,α-diphenyl-4-(p-chlorophenyl)-4-hydroxyl-1-loperamide hydrochloride (from 2 , 2-diphenyl-4-bromobutyric acid as raw material, obtained after chlorination, amination, condensation, and salt formation), the chemical structure is similar to haloperidol and meperidine, but the therapeutic dose has no effect on the central nervous system effect. It has the pharmacological effect of preventing the release of acetylcholine and prostaglandins, thereby inhibiting intestinal peristalsis and prolonging the residence time of intestinal contents. [0003] Loperamide hydrochloride is a white or off-white crystalline powder, almost odorless, with a bitter taste. Soluble in ethanol or glacial acetic acid, slightl...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/451A61K47/36A61K47/12A61P1/12A61K31/7004
CPCA61K9/1652A61K9/1617A61K31/451A61K31/7004A61K2300/00
Inventor 操铖高煜
Owner HUAYI PHARMA ANHUI CO LTD