Preparation method of antibacterial peptide gynecological gel

A technology of peptide gynecology and gel, which is applied in the field of preparation of antibacterial peptide gynecology gel, can solve the problems of unsuitable absorption and long-lasting prevention, destroying the ecological balance of vaginal colonies, and unsuitable for preventive use, etc., to achieve accelerated killing Kill pathogenic bacteria, excellent breeding conditions, and the effect of peaceful absorption

Active Publication Date: 2018-03-20
吉安市御美丽生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, gynecological gel uses nano-silver ions, which have anti-inflammatory, bactericidal, and antipruritic effects, and can significantly inhibit the growth of pathogenic microorganisms such as Staphylococcus aureus, Escherichia coli, Neisseria gonorrhoeae, Candida albicans, fungi, and yeasts. Antibiotics are mainly used Treatment, but also kills the beneficial flora (lactobacillus, vaginal bifidobacteria), destroying the ecological balance of the vaginal flora
And the manufacturing cost is high, and the contact reaction is strong, so it is not suitable for preventive use
[0005] CN101099815A discloses gynecological antibacterial gel and preparation method thereof, specifically discloses a medicinal composition for antibacte

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method of antimicrobial peptide gynecological gel, comprising the following steps:

[0034] 1) Take honeybees, heat them at 50°C for 2 hours, dry the whole insects, and crush them to obtain honeybee powder; the honeybees are Italian honeybees; the particle size of the honeybee powder is 1mm;

[0035] 2) Put the honeybee powder into the glycerin-acetic acid solution containing arginine, soak for 12 hours, and ultrasonically vibrate for 10 minutes to obtain a mixed solution; the volume fraction of glycerol in the glycerin-acetic acid solution is 15%; the arginine is The concentration of glycerol-acetic acid solution is 0.5mol / L;

[0036] 3) Filter the mixed solution to remove the filter residue, heat the filtrate at 80°C for 60 minutes, concentrate to a density of 1.4g / ml, and obtain the bee extract;

[0037] 4) Prepare according to the following proportions by mass: 4 parts of bee extract, 10 parts of loofah juice, 8 parts of aloe vera powder with a partic...

Embodiment 2

[0039] A preparation method of antimicrobial peptide gynecological gel, comprising the following steps:

[0040] 1) Take honeybees, heat them at 70°C for 1 hour, dry the whole insects, and crush them to obtain honeybee powder; the honeybees are high-yield royal jelly bees; the particle size of the honeybee powder is 5mm;

[0041] 2) Put the honeybee powder into the glycerin-acetic acid solution containing arginine, soak for 20 hours, and ultrasonically vibrate for 20 minutes to obtain a mixed solution; the volume fraction of glycerol in the glycerin-acetic acid solution is 30%; the arginine in The concentration of glycerol-acetic acid solution is 1mol / L;

[0042] 3) Filter the mixed solution to remove the filter residue, heat the filtrate at 100°C for 40 minutes, concentrate to a density of 1.6g / ml, and obtain the bee extract;

[0043] 4) Prepare according to the following proportions by mass: 8 parts of bee extract, 15 parts of loofah juice, 10 parts of aloe vera powder with...

Embodiment 3

[0045] A preparation method of antimicrobial peptide gynecological gel, comprising the following steps:

[0046] 1) Take honeybees, heat them at 60°C for 1.5h, dry the whole insects, and crush them to obtain honeybee powder; the honeybees are Anatolian honeybees; the particle size of the honeybee powder is 3mm;

[0047] 2) Put the honeybee powder into the glycerin-acetic acid solution containing arginine, soak for 15 hours, and ultrasonically vibrate for 15 minutes to obtain a mixed solution; the volume fraction of glycerol in the glycerin-acetic acid solution is 22%; the arginine in The concentration of glycerol-acetic acid solution is 0.8mol / L;

[0048] 3) Filter the mixed solution to remove the filter residue, heat the filtrate at 90°C for 50 minutes, concentrate to a density of 1.5g / ml, and obtain the bee extract;

[0049] 4) Prepare according to the following proportions by mass: 6 parts of bee extract, 12 parts of loofah juice, 9 parts of aloe vera powder with a particle ...

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Abstract

The invention discloses a preparation method of antibacterial peptide gynecological gel which has the advantages of moderate absorption, lasting curative effect and capability of adjusting the ecological balance of a vagina. The preparation method comprises the following steps: 1) taking honeybees; heating and drying the honeybees; crushing the dried honeybees to obtain honeybee powder; 2) addingthe honeybee powder into a glycerol-acetic acid solution containing arginine; immersing for 12h to 20h and carrying out ultrasonic vibration for 10min to 20min to obtain a mixed solution; 3) filteringthe mixed solution to remove filter residues; heating filtrate at 80 DEG C to 100 DEG C for 40min to 60min; concentrating to obtain a honeybee extracting solution; 4) adding towel gourd juice and aloe powder into the honeybee extracting solution and stirring at 30 DEG C to 50 DEG C for 20min to 40min; then adding an MgCl2 solution; after stirring, carrying out freeze-drying; recovering room temperature in air with the relative humidity of 60 percent to 80 percent to obtain the antibacterial peptide gynecological gel.

Description

technical field [0001] The invention relates to the technical field of gynecology, in particular to a preparation method of an antibacterial peptide gynecological gel. Background technique [0002] Under the action of endocrine hormones in the vagina of healthy women, the epithelial cells proliferate, and the surface cells are rich in glycogen, which is conducive to the growth of Lactobacillus, which accounts for more than 90% of the vagina. The presence of a large number of such lactobacilli inhibits the growth of other pathogenic bacteria and forms a normal ecological balance in the vagina. [0003] When a large number of external pathogens invade and destroy the defense function of the vagina, the microecological balance of the normally parasitic vaginal flora becomes imbalanced, beneficial bacteria such as Lactobacillus in the vagina decrease while other bacteria proliferate in large numbers, and anaerobic bacteria reproduce and produce amines and alkalis at the same tim...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K38/02A61K9/06A61P15/02A61P31/04A61P31/02A61K36/896A61K36/886A61K33/06
CPCA61K9/0034A61K9/06A61K33/06A61K36/42A61K36/886A61K36/896A61K38/02A61K35/63A61K2300/00
Inventor 尹志明刘动勤彭松涛
Owner 吉安市御美丽生物科技有限公司
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