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Cefaclor preparation and preparation method thereof

A technology for cefaclor and preparations, applied in the field of drug preparation, can solve problems such as poor absorption effect, and achieve the effects of high drug loading, sufficient and rapid disintegration, and promotion of dissolution

Active Publication Date: 2021-02-19
SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral preparations that are easy to take, especially dispersible tablet preparations, are rare, mainly because β-lactamase inhibitors are mostly water-soluble substances, but the oral absorption effect is poor

Method used

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  • Cefaclor preparation and preparation method thereof
  • Cefaclor preparation and preparation method thereof
  • Cefaclor preparation and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0084] In the present invention, the preparation method comprising the cefaclor dispersible tablet preparation of sulbactam sodium liposome comprises the following steps:

[0085] Step 1), sulbactam sodium, egg yolk lecithin, cholesterol, dicetyl phosphate, and macromolecule polyethylene glycol are made into sulbactam sodium liposome;

[0086] Step 2), sieve the weighed cefaclor, emulsifier (such as polyethylene glycol 6000 and poloxamer 188), sulbactam sodium liposome and set auxiliary materials, mix, make soft material, pass Screen wet granules, dry, sieve and granulate;

[0087] Preferably, cefaclor and emulsifiers (such as polyethylene glycol 6000 and poloxamer 188) are pre-mixed, and then mixed with sulbactam sodium liposome and setting excipients.

[0088] Step 3), after adding lubricant and mixing, tableting to obtain cefaclor dispersible tablets.

[0089] Wherein, in step 2), the setting auxiliary materials include disintegrants, fillers, binders, swelling auxiliary ...

Embodiment 1

[0097] The preparation of embodiment 1 cefaclor dispersible tablet (do not contain sulbactam sodium)

[0098] The raw materials used are as follows:

[0099]

[0100] Adopt following production process to prepare cefaclor dispersible tablet:

[0101] (1), passing the weighed cefaclor, polyethylene glycol 6000, poloxamer 188 and the above-mentioned auxiliary materials through a 50-mesh sieve;

[0102] (2) After pre-mixing cefaclor with polyethylene glycol 6000 and poloxamer 188, mix it evenly with cross-linked polyvinylpyrrolidone, microcrystalline cellulose, hydroxypropyl methylcellulose and mannitol, Add water to make soft material, pass through 18-mesh sieve to granulate, dry at 60°C for 2 hours, and then granulate with 18-mesh sieve;

[0103] (3) Add magnesium stearate and pregelatinized starch, mix and compress to obtain cefaclor dispersible tablets, which contain 0.25g / tablet of cefaclor.

Embodiment 2

[0104] The preparation of embodiment 2 cefaclor dispersible tablets (do not contain sulbactam sodium)

[0105] The raw materials used are as follows:

[0106]

[0107] The production process of preparing cefaclor dispersible tablets is the same as that of Example 1, which contains 0.25 g / tablet of cefaclor, and the weight ratio of polyethylene glycol 6000 and poloxamer 188 is 1:1.

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Abstract

The invention discloses an oral constant-release preparation of cefaclor, such as dispersible tablets, capsules and dry suspensions, and a preparation method thereof. In the cefaclor oral constant-release preparation provided by the invention, cefaclor has high dissolution rate, high bioavailability, remarkable drug effect, and dissolves rapidly in water, which improves the quality of the preparation product, ensures the safety and effectiveness of the product, and simultaneously Bring new options to children's medication.

Description

technical field [0001] The invention relates to medicine preparation technology, in particular to an original developed quality cefaclor preparation and a preparation method thereof. Background technique [0002] Cefaclor, the English name is Cefaclor (Ceclor), the chemical name is (6R, 7R)-7-[(R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-5- Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate. Its chemical structural formula is as follows: [0003] [0004] Cefaclor is a second-generation oral cephalosporin, which has a strong killing effect on a variety of Gram-positive and Gram-negative bacteria. This product is a broad-spectrum semi-synthetic cephalosporin antibiotic. The activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococcus, viridans streptococcus and staphylococcus epidermidis is the same as that of cefadroxil, and the antibacterial effect against non-enzyme-producing staphylococcus aureus and pneumococcus is h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/127A61K47/10A61K47/32A61K47/36A61K47/24A61K47/28A61K31/545A61K31/43A61P31/04
CPCA61K9/127A61K9/2027A61K9/2031A61K9/2059A61K9/2095A61K31/43A61K31/545A61K47/24A61K47/28A61K2300/00
Inventor 傅苗青周白水巩绪彦邱鑫奎
Owner SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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