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Tumor diagnosis and treatment nano-material based on manganese and dopamine, and preparation method and application thereof

A technology of nanomaterials and dopamine, applied in nanotechnology for sensing, nanotechnology, nanotechnology, etc., can solve the problems of toxic side effects, low relaxation rate of small molecule gadolinium contrast agent, low contrast intensity, etc., to achieve toxicity Small side effects, long circulation time in the body, and the effect of inhibiting proliferation

Active Publication Date: 2018-04-13
ZHEJIANG UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the relaxation rate of small molecule gadolinium contrast agents is generally low, resulting in low contrast intensity, and more and more reports indicate that the toxic side effects (renal fibrosis, brain accumulation, etc.) associated with gadolinium contrast agents do exist

Method used

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  • Tumor diagnosis and treatment nano-material based on manganese and dopamine, and preparation method and application thereof
  • Tumor diagnosis and treatment nano-material based on manganese and dopamine, and preparation method and application thereof
  • Tumor diagnosis and treatment nano-material based on manganese and dopamine, and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1. Preparation of nanomaterials

[0046] (1) Add 100 mg of dopamine and 200 mg of BSA to 100 mL of deionized water, then slowly add 30 mg of potassium permanganate, and react at room temperature for 2 h.

[0047] (2) Dialysis (Mw=10000) for 48-72 hours.

[0048] (3) freeze-drying or ultrafiltration and centrifugal concentration to obtain the nanomaterial BMD8.

[0049] 2. Performance analysis of nanomaterials

[0050] Such as figure 1 As shown, the average particle diameter of the nanomaterial BMD8 measured by dynamic light scattering (DLS) is 60 nm (distribution coefficient PDI=0.146).

[0051] Such as figure 2 As shown, the particle size of nanomaterial BMD8 observed by transmission electron microscope (TEM) is about 60nm, which is consistent with the particle size result measured by DLS.

[0052] Such as image 3 As shown, the manganese content of the nanomaterial BMD8 is 3%, and the relaxation rate R1 value is 38.14mM -1 ·s -1 .

[0053] Such as Figure 4...

Embodiment 2

[0063] Nanomaterials were prepared according to the reaction conditions in Table 1, and the technical process was referred to in Example 1. The properties of the prepared products were analyzed, and the results are shown in Table 1.

[0064] Table 1

[0065]

[0066] Note: In the above table, BMD: prepared nanomaterials; DA: dopamine; BSA: bovine serum albumin; KMnO 4 :potassium permanganate.

[0067] From the preparation of BMD1-5 in the above table, it can be seen that when the concentration of potassium permanganate exceeds a certain concentration, the relaxation rate of nanomaterials does not increase but decreases. When there is no BSA, both dopamine and potassium permanganate cannot form nanoparticles or the nanoparticles are too large, and the particles that are too large cannot be enriched in the tumor tissue through the EPR effect, and are easily trapped by the reticuloendothelial system. , not suitable for use as the magnetic resonance imaging contrast agent and...

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Abstract

The invention discloses a tumor diagnosis and treatment nano-material based on manganese and dopamine, and a preparation method thereof, and belongs to the field of magnetic resonance imaging mediatedphotothermal therapy diagnosis and treatment integration materials. The preparation method of the nano-material comprises the following steps: adding dopamine, bovine serum albumin and potassium permanganate into an aqueous medium, carrying out a reaction at room temperature, and self-assembling the obtained product to form the nano-material. Two oxidation reactions are simultaneously driven by one oxidizer, and in-situ polymerization self-assembling is driven to prepare an efficient manganese-based nanometer macromolecular contrast agent, so the relaxivity is high; and the nano-material hasa high photo-thermal conversion efficiency in a near-infrared region, can be applied to photothermal therapy as a photothermal therapy agent, can monitor the positions and the sizes of tumors and theenrichment state of the photothermal therapy agent in tumor tissues by means of a magnetic resonance technology, can be used to evaluate the therapy effect, and realizes magnetic resonance imaging mediated photothermal therapy diagnosis and treatment integration.

Description

technical field [0001] The invention relates to the field of integrated materials for diagnosis and treatment of photothermal therapy mediated by magnetic resonance imaging, in particular to a nanomaterial for diagnosis and treatment of tumors based on manganese and dopamine and its preparation method and application. Background technique [0002] Photothermal therapy (PTT) is a treatment method that uses materials with high photothermal conversion efficiency to convert light energy into heat energy under near-infrared light conditions, resulting in local high temperature of tumor cells, thereby killing cancer cells. In the past few years, a variety of nanomaterials with strong near-infrared absorption, including various inorganic nanoparticles such as gold nanoparticles, carbon nanomaterials, palladium flakes, copper sulfide, bismuth sulfide, and organic nanoparticles such as polydopamine, have been investigated. As a photothermal agent for tumor photothermal therapy. Sinc...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/12A61K49/14A61K49/18A61P35/00B82Y5/00B82Y15/00
CPCA61K41/0052A61K49/126A61K49/143A61K49/1818B82Y5/00B82Y15/00
Inventor 唐建斌肖冰周晓璇胡红杰申有青
Owner ZHEJIANG UNIV
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