Method for producing diosgenin by combining microwave and hot pressing decomposition technology

Abstract

The invention discloses a method for producing diosgenin through combined use of microwaves and hot pressing decomposition technology. A microwave radiation pressurized decomposition method is used; asaponin compound separated from dioscorea plant raw materials is put into a sealed microwave device for microwave radiation; the microwave power radiation power is controlled at 300 to 900 W; the temperature in the reaction system is controlled to be 100 to 200 DEG C; the pressure is 1 to 10 MPa; the pressure maintaining time is 5 to 30min; then, the pressure relief is performed; the dioscin is subjected to glycosyl removal under the microwave radiation and pressurized heating conditions and is converted into diosgenin. The method has the advantages that the glucosidic bonds of the dioscin can be effectively cracked in a short time; the diosgenin extraction rate is improved; the production cost is reduced. In the production process, acid hydrolysis is not needed; a great amount of acid waste water generated by acid hydrolysis can be avoided; starch and cellulose obtained through separation can be comprehensive utilized; the method is a diosgenin clean production process suitable for industrial mass production.

Description

technical field [0001] The invention relates to a preparation method of a compound, in particular to a production method of diosgenin. Background technique [0002] Diosgenin (commonly known as saponin), diosgenin is an ideal precursor for the synthesis of various steroid hormones and steroidal contraceptives, more than 60% of the steroid hormones produced in the world use it as a raw material. At present, there are many manufacturers in my country producing steroid hormone drugs and steroid oral contraceptives, which are an important field next to antibiotics in drug production. my country has used the self-produced diosgenin ligands to synthesize more than 200 kinds of drugs. In addition to hormones for anti-inflammation and contraception, it also uses steroid starting materials to synthesize analgesics, anesthetics, and coronary heart disease drugs. [0003] Diosgenin, that is, diosgenin, is insoluble in water but soluble in organic solvents such as methanol and petroleu...

AI Technical Summary

Problems solved by technology

[0005] At home and abroad, various improvements have been made around increasing the yield of saponin, reducing production costs, and reducing pollution emissions. Some have carried out pre-fermentation or enzymatic hydrolysis before hydrolysis, and some have used microwave extraction and ultrasonic extraction in the extraction stage, but the main The production technology route has not changed fundamentally, and saponin is still extracted by first hydrolyzing and then extracting, the amount of waste water has not been significantly reduced, cellulose and starch cannot be comprehensively utilized, and the environmental protection problem cannot be fundamentally solved; The cellulose and starch in the plant are separated, and then hydrolyzed and extracted. Although this method reduces the amount of acid and waste water, it does not completely solve the problem of pollution discharge, and the extraction rate of saponin is often not high; there are reports Some people use thermal decomposition method to extract saponin, because saponin exists in plants in the form of saponin and is wrapped by starch, so this method cannot completely convert saponin into saponin, even if it is converted into saponin, it is difficult to extract Because the starch is gelatinized at high temperature, it is difficult for the organic solvent to penetrate into the plant, the thermal decomposition takes a long time, the glycosidic bond cracking rate is not complete, and the saponin extraction rate is very low