Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of asarone-containing patch and preparation method thereof

A Xinnao patch and asarone technology, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, sheet-like delivery, etc., can solve the problem of poor reconstitution effect of freeze-dried powder injection, complex preparation process and product quality. It is not easy to guarantee and other problems, to achieve the effect of avoiding toxic effects, simple production process, and avoiding the first-pass effect

Active Publication Date: 2021-08-03
FERGUSON WUHAN BIOTECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Asarone is insoluble in water, and it is generally necessary to add a lot of solubilizing agents to make injections, such as Tween 80, etc., and the side reactions of injections are many, and the product quality is difficult to guarantee
The reconstitution effect of freeze-dried powder injection is relatively poor, and the preparation process is complicated

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of asarone-containing patch and preparation method thereof
  • A kind of asarone-containing patch and preparation method thereof
  • A kind of asarone-containing patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A patch containing asarum, the formula consists of the following ingredients:

[0042] Drug storage layer (1000 stickers):

[0043]

[0044] Made: 1000 patches, each patch dose 15g.

[0045] The preparation method is as follows:

[0046] Disperse carbomer in purified water for 12 to 24 hours in a stirring tank, dissolve ethylparaben in propylene glycol and add to the stirring tank, then dissolve aluminum trichloride and citric acid with an appropriate amount of purified water and add to the In the stirring tank, add micronized asarone (D90 less than 20 μm), mono- and diglycerin stearate, Tween 80, and glycerin into the stirring tank, turn on the stirring paddle, and stir for 20 minutes. Then add triethanolamine and stir evenly, control the pH between 5.8 and 6.2, then vacuumize to remove air bubbles, and maintain the vacuum degree at <25Pa. Spread the prepared gel on the non-woven fabric, cover it with an adhesive layer, and cut it into a patch of suitable size ac...

Embodiment 2

[0048] A patch containing asarum, the formula consists of the following ingredients:

[0049] Drug storage layer (1000 stickers):

[0050]

[0051]

[0052] Made: 1000 patches, each patch dose 15g.

[0053] The preparation method is as follows:

[0054] Disperse carbomer and sodium polyacrylate 7S in purified water for 12 to 24 hours in a stirring tank, dissolve methylparaben and propylparaben in propylene glycol, and then add aluminum trichloride and lemon Dissolve the acid with an appropriate amount of purified water and add it to the mixing tank, then add micronized asarone (D90 less than 20 μm), mono- and diglycerin stearate, Tween 80 and glycerin into the mixing tank, and turn on the stirring paddle , stirred for 20min. Then add triethanolamine and stir evenly, control the pH between 5.8~6.2, then vacuumize to remove air bubbles, and maintain the vacuum degree at <25Pa. Spread the prepared gel on a non-woven fabric, cover with an adhesive layer, and cut it into ...

Embodiment 3

[0056] A patch containing asarum, the formula consists of the following ingredients:

[0057] Drug storage layer (1000 stickers):

[0058]

[0059] Made: 1000 patches, each patch dose 15g.

[0060] The preparation method is as follows:

[0061] Disperse sodium carboxymethylcellulose and sodium polyacrylate 7S in purified water for 1 to 2 hours in a stirring tank, then dissolve potassium sorbate, aluminum trichloride and citric acid with an appropriate amount of purified water and add them to the stirring tank , and then add micronized asarone (D90 less than 20 μm), mono- and diglyceride stearate, Tween 80, and glycerin into the stirring tank, turn on the stirring paddle, and stir for 20 minutes. Adjust the pH value, control the pH between 5.8 and 6.2, and stir evenly. Then vacuumize to remove air bubbles, and maintain the vacuum at <25Pa. Spread the prepared gel on a non-woven fabric, cover it with an adhesive layer, and cut it into a patch of an appropriate size accord...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses an asarone-containing patch, which relates to the technical field of pharmaceutical preparations. The asarone-containing patch is a catarrh plaster, and in parts by mass, the asarone-containing patch includes 1 part of asarone, 3 ~5 parts penetration aid and 94-96 parts matrix. The asarone-containing patch of the present invention is added with a penetration aid, so that the asarone has a better skin penetration rate, and the transmission rate can maintain a stable zero-order release. It overcomes the shortcomings of poor compliance of injections, and only needs to be pasted on the forehead or other skins to cool and reduce fever; at the same time, it is obviously better than granules or oral suspensions, and can avoid the first-pass effect of the liver and gastrointestinal irritation. It has the characteristics of definite curative effect, stable quality, good safety and few side effects. The invention discloses a preparation method of a patch containing asarone.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a patch containing asarone and a preparation method thereof. Background technique [0002] The main component of asarone is α-asarone, which is the main active ingredient of the traditional Chinese medicine Shichangpu. Asthma: This product can resist histamine, acetylcholine, and relieve bronchospasm; Cough: It has a strong inhibitory effect on the cough center; expectorant: This product can increase airway secretions and dilute sputum; Sedation: Can significantly reduce Spontaneous activity without inhibition; antispasmodic: similar to aminophylline, it has the effect of relaxing bronchial smooth muscle; anticonvulsant: a~asarone can increase the point stimulation threshold of cerebral cortex, inhibit the synaptic conduction of electrical stimulation and epileptic discharge , has a significant effect on grand mal seizures. [0003] Its structural formula is...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/09A61K47/32A61P11/00A61P11/14A61P11/10A61P11/06
CPCA61K9/7061A61K31/09
Inventor 刘欣黄飞赵小伟
Owner FERGUSON WUHAN BIOTECH