A kind of method that microchannel reactor carries out cyano hydrolysis reaction

Abstract

The invention discloses a method for hydrolyzing cyano-based compounds based on a microchannel reactor. Specifically, compounds containing cyano groups in their molecules are reacted using a microchannel reaction under the action of alkaline or acid-base substances. for cyanohydrolysis reactions. In the process of the present invention, the microchannel reactor is used to realize instantaneous uniform mixing of raw materials and high-efficiency heat transfer; when the most important cyano compounds are hydrolyzed with alkali, the risk of material flushing in the production process is solved; at the same time, the reaction process is also reduced The equivalent ratio of the materials in the medium; the occurrence of side reactions is reduced; and the reaction time is shortened to tens of minutes or even tens of seconds. In a word, the process of the present invention improves the safety of the reaction operation, realizes the safe scale-up production of cyano-based compounds, shortens the reaction time for hydrolysis of cyano-based compounds, improves the selectivity and efficiency of the reaction, and reduces the production time. The energy consumption is reduced, the utilization rate of raw materials is improved, the production process is more environmentally friendly, and the production cost is low. At the same time, the equipment used has a small footprint and high production capacity, which greatly improves production efficiency and capacity.

Description

technical field [0001] The invention relates to a method for carrying out cyano group hydrolysis reaction in a microchannel reactor, specifically, in the microchannel reactor, molecules containing cyano groups are hydrolyzed with lye or acid solution to generate compounds containing carboxyl groups, It belongs to the field of organic synthesis. Background technique [0002] Micro-reaction technology originated in the 1990s. In recent years, the advantages of micro-reactors have gradually become prominent, and they realized that micro-reactors are stronger than conventional mass and heat transfer capabilities, so micro-reactors were applied to the field of chemical synthesis; micro-reactions With the development of the device today, it is no longer simply pursuing the miniaturization of the reaction channel, but changing the fluid flow pattern through the reaction channel to form a micro-scale liquid flow, forming efficient and rapid mass and heat transfer. Utilizing these a...

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Problems solved by technology

This type of reaction can usually be hydrolyzed relatively completely under alkaline conditions, but cannot be completely reacted under acidic conditions. Under normal temperature and pressure conditions, the hydrolysis time of the cyano group is relatively long, and the hydrolysis efficiency is low. Often the reaction cannot be carried out completely, and amides and The mixture of carboxylic acids makes the purity of the final product not enough, so it is necessary to increase the temperature and pH of the hydrolysis, especially under the commonly used alkaline conditions, increasing the temperature will violently produce gas, it is difficult to control the reaction, and the risk is relatively large; and The conventional reaction is incomplete under acidic conditions, and the amount of acid needs to be increased. These excess acids and bases also need to be neutralized, resulting in unnecessary waste and environmental pollution

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