Florfenicol premixing agent and preparation method thereof

Abstract

The invention discloses a florfenicol premixing agent. The florfenicol premixing agent is prepared from the following raw materials in parts by weight: 2 to 3 parts of florfenicol bulk drugs, 2 to 15parts of active auxiliary materials, 2 to 10 parts of carriers, 10 to 25 parts of dissolution agent, 2 to 10 parts of stabilizer, and the balance of filling agent. The obtained florfenicol premixing agent has the advantages of high biological activity, high bioavailability, high stability, low cost, small toxicity and side effect, multiple effects and capability of promoting the growth of animals.By adopting the preparation method of the invention, the defects of a conventional complicated solid inclusion process can be avoided, the use of expensive reagent can be avoided, the process flow issimple, the cost is simple, and the preparation method has positive popularization significance.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a florfenicol premix and a preparation method of the florfenicol premix. Background technique [0002] Florfenicol, a synthetic fluorine derivative of chloramphenicol, is a new generation of broad-spectrum chloramphenicol antibiotics for animals. It is effective in treating bacterial diseases of pigs, cattle, chickens and fish caused by sensitive bacteria, and has a significant curative effect on respiratory system infection and intestinal infection, and has low residual in the body, and has the advantages of no potential aplastic anemia. It was approved for marketing in my country in April 1999, and was approved as a national second-class new veterinary drug by the Ministry of Agriculture. [0003] The florfenicol raw material is almost insoluble in water, and its oral bioavailability is low. Some studies have made florfenicol into solid dispersions, polysaccharide di...

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Problems solved by technology

[0003] The florfenicol raw material is almost insoluble in water, and its oral bioavailability is low. Some studies have made florfenicol into solid dispersions, polysaccharide dispersions, β-cyclodextrin inclusion complexes and other preparations, but the obtained products The in vitro dissolution rate of the drug is relatively slow; some studies have also made hydroxypropyl-cyclodextrin inclusion complexes, which have improved the in vitro dissolution rate of the drug to a certain extent, but the production cost is high, which is not conducive to popularization.

Florfenicol premix refers to the powder or granular preparation prepared by uniformly mixing florfenicol raw material and suitable matrix, which is convenient for mixing and feeding, but it needs long-term use or large-dose administration to achieve The problem of blood drug concentration causes the drug to be uncontrolled and the drug residue increases. Therefore, only by improving the bioavailability of the Florfenicol premix, increasing the release rate of the active substance and the dissolution rate in vitro, can the normal function of Florfenicol be brought into play. At the same time, cost control under the premise of improving drug efficacy is also an urgent problem to be solved

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