High efficiency production method of glycine

Abstract

The invention discloses a high efficiency production method of glycine. The high efficiency production method comprises following steps: solvent methanol or ethanol, and catalyst urotropine or paraformaldehyde are introduced into a reactor, Ammonium-monochloracetat is added, the temperature is increased to 60 to 70 DEG C, N,N-Diisopropylethylamine or N,N-Diethylbenzylamine or N, N-di-n-propyl benzylamine or N, N-di-n-butyl benzylamine are added dropwise in 2h, thermal insulation reaction is carried out at 65 to 75 DEG C for 2.5h, the temperature is reduced to 40 to 50 DEG C for precipitation of glycine crystal, or the temperature is reduced to 10 to 25 DEG C for precipitation of a mixture of glycine crystal and an ammonium salt; and then filtering, washing, and drying are carried out successively so as to obtain a glycine product, wherein a washing liquid is adopted for recycling of N,N-Diisopropylethylamine or N,N-Diethylbenzylamine or N, N-di-n-propyl benzylamine or N, N-di-n-butyl benzylamine. The glycine yield is increased by 10% of that in the prior art; energy consumption is reduced; catalyst recycling is realized; recycling of N,N-Diisopropylethylamine or N,N-Diethylbenzylamine or N, N-di-n-propyl benzylamine or N, N-di-n-butyl benzylamine is realized; and combined production of ammonium chloride is realized.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, in particular to a high-efficiency production process of glycine. Background technique [0002] Glycine is the simplest amino acid, and it is widely used in chemical industry, pesticide, medicine, food and farming. At present, the Strecker synthesis method is mainly used to produce glycine in the United States, Japan and other countries, and the ammonolysis synthesis method of chloroacetic acid is used in China. The process of ammonolysis synthesis of chloroacetic acid is: react chloroacetic acid, ammonia, and urotropine in water, add a large amount of methanol to precipitate glycine, produce a ton of glycine to produce methanol mother liquor of more than ten cubic meters, and recover methanol requires a large amount of energy. The main shortcoming of chloroacetic acid ammonolysis synthetic method: energy consumption is high, and yield is low (about 85%), also has a large amount of cat...

AI Technical Summary

Problems solved by technology

The main shortcoming of chloroacetic acid ammonolysis synthetic method: energy consumption is high, and yield is low (about 85%), also has a large amount of catalysts (hexamethamine) to be difficult to recycle

[0003] Chinese patent application "A kind of clean production process of glycine co-production ammonium chloride" (public number: CN103570568), and Chinese patent application "a kind of clean production process of glycine co-production calcium chloride" (public number: CN103450039), both The reaction of ammonium chloroacetate and triethylamine under the catalysis of urotropine generates glycine and triethylamine hydrochloride, and the product glycine and triethylamine hydrochloride are preferably separated, but the former needs to be separated from triethylamine hydrochloride. Freeze to -20°C, the latter needs to be frozen to -10°C to separate triethylamine hydrochloride, resulting in high energy consumption and limited industrial production value