Composite material esophagus repairing patch

Abstract

The invention discloses a composite material esophagus repairing patch. The composite material esophagus repairing patch is characterized by comprising a repairing patch body and a biological glue layer coating one surface of the repairing patch body, wherein the repairing patch body is prepared from polytetrafluoroethylene nano-composite materials. According to the composite material esophagus repairing patch, the repairing of orificium fistulae of tracheo-esophageal fistulae can be realized without a stent structure, so that various problems caused due to the use of a stent during the repairing in the prior art are avoided; meanwhile, by utilizing a repairing patch structure, the biological glue layer is capable of closing tissue defects, so that the radiotherapy of the tracheo-esophageal fistulae can be realized; and by adding graphene and inorganic powder into polytetrafluoroethylene, the mechanical properties and wear resistance of the material are improved, and meanwhile, and thematerial has high biocompatibility, elasticity and tenacity and further has the properties of tensile resistance, acid resistance, base resistance and radiation resistance.

Description

technical field [0001] The invention relates to a medical device, in particular to a composite material esophageal patch for treating tracheoesophageal fistula. Background technique [0002] Malignant tracheoesophageal fistula (malignant tracheoesophageal fistula, MTEF) is a serious complication originating from sub-tumors in the esophagus and other parts. [0003] Surgery and esophageal stent implantation are currently the most commonly used treatment methods, but neither is ideal. Surgical treatment of selected patients with successful MTEF has an average survival time of 13 months, but the risk of intraoperative death is as high as 14.3%, and the vast majority of patients cannot be operated on due to local inflammation, edema, infection, and advanced tumors. There are also many defects in the implantation of esophageal stent grafts: 1. The stent needs to cover the normal esophageal wall of at least 2 cm at the proximal and distal ends of the fistula, and it must be wide ...

AI Technical Summary

Problems solved by technology

[0003] Surgery and esophageal stent implantation are the most commonly used treatment methods, but neither is ideal

Surgical treatment of selected patients with successful MTEF has an average survival period of 13 months, but the risk of intraoperative death is as high as 14.3%, and most patients cannot be operated on due to local inflammation, edema, infection, and advanced tumors

There are also many defects in the implantation of esophageal stent-graft: 1. The stent needs to cover the normal esophageal wall of at least 2cm at the proximal and distal ends of the fistula, and it must be wide enough to be firmly fixed

3. Lack of effective follow-up methods to control the tumor, which does not significantly prolong the survival time of patients, and the median survival time is only about 8 weeks

[0004] In addition, radiotherapy plays an important role in the treatment of advanced esophageal cancer, but once tracheoesophageal fistula occurs, it is an absolute contraindication to radiotherapy. Even after stent implantation, radiotherapy may lead to tumor necrosis, further expansion of the fistula, and prolong the healing of the fistula The risk of time, it is not suitable to continue radiotherapy